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Low alkaline phosphatase of bone origin

MedGen UID:
869315
•Concept ID:
C4023741
•
Finding
Synonym: Low ALP of bone origin
 
HPO: HP:0010684

Definition

An abnormally reduced level of bone isoforms of alkaline phosphatase in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow alkaline phosphatase of bone origin

Professional guidelines

PubMed

Enhancing precision: A predictive model for (177)Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative (68)Ga-DOTATATE PET and clinicopathological biomarkers.
Akhavanallaf A, Joshi S, Mohan A, Worden FP, Krauss JC, Zaidi H, Frey K, Suresh K, Dewaraja YK, Wong KK
Theranostics 2024;14(9):3708-3718. Epub 2024 Jun 11 doi: 10.7150/thno.98053. PMID: 38948061Free PMC Article
Monitoring of bone turnover biological, preanalytical and technical criteria in the assessment of biochemical markers.
Withold W
Eur J Clin Chem Clin Biochem 1996 Oct;34(10):785-99. PMID: 8933101

Recent clinical studies

Etiology

Enhancing precision: A predictive model for (177)Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative (68)Ga-DOTATATE PET and clinicopathological biomarkers.
Akhavanallaf A, Joshi S, Mohan A, Worden FP, Krauss JC, Zaidi H, Frey K, Suresh K, Dewaraja YK, Wong KK
Theranostics 2024;14(9):3708-3718. Epub 2024 Jun 11 doi: 10.7150/thno.98053. PMID: 38948061Free PMC Article
Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: a US population-based study.
Silverberg JI
Pediatr Allergy Immunol 2015 Feb;26(1):54-61. doi: 10.1111/pai.12315. PMID: 25443466
Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells.
Stein E, Koehn J, Sutter W, Wendtlandt G, Wanschitz F, Thurnher D, Baghestanian M, Turhani D
Wien Klin Wochenschr 2008;120(3-4):112-7. doi: 10.1007/s00508-008-0932-6. PMID: 18322773
Monitoring of bone turnover biological, preanalytical and technical criteria in the assessment of biochemical markers.
Withold W
Eur J Clin Chem Clin Biochem 1996 Oct;34(10):785-99. PMID: 8933101
Some properties of acid and alkaline phosphatase in seminal fluid and isolated sperm.
Singer R, Barnet M, Allalouf D, Schwartzman S, Sagiv M, Landau B, Segenreich E, Servadio C
Arch Androl 1980 Sep;5(2):195-9. doi: 10.3109/01485018008986315. PMID: 7425726

Diagnosis

Paget Disease of Bone Harboring Bone Metastatic Neuroendocrine Cancer: A Case Report.
Briganti SI, Lanza O, Fioriti E, Leto G, Battisti S, Napoli N, Strollo R
Calcif Tissue Int 2024 May;114(5):550-553. Epub 2024 Mar 20 doi: 10.1007/s00223-024-01195-3. PMID: 38506956
Identifying adult hypophosphatasia in the rheumatology unit.
Feurstein J, Behanova M, Haschka J, Roetzer K, Uyanik G, Hadzimuratovic B, Witsch-Baumgartner M, Schett G, Zwerina J, Kocijan R
Orphanet J Rare Dis 2022 Dec 14;17(1):435. doi: 10.1186/s13023-022-02572-7. PMID: 36514157Free PMC Article
Challenging case of tumour-induced osteomalacia.
Kumar P, Jadhav DV, Ravat SH, Jain N
BMJ Case Rep 2022 May 19;15(5) doi: 10.1136/bcr-2022-249200. PMID: 35589273Free PMC Article
Monitoring of bone turnover biological, preanalytical and technical criteria in the assessment of biochemical markers.
Withold W
Eur J Clin Chem Clin Biochem 1996 Oct;34(10):785-99. PMID: 8933101
Some properties of acid and alkaline phosphatase in seminal fluid and isolated sperm.
Singer R, Barnet M, Allalouf D, Schwartzman S, Sagiv M, Landau B, Segenreich E, Servadio C
Arch Androl 1980 Sep;5(2):195-9. doi: 10.3109/01485018008986315. PMID: 7425726

Therapy

Enhancing precision: A predictive model for (177)Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative (68)Ga-DOTATATE PET and clinicopathological biomarkers.
Akhavanallaf A, Joshi S, Mohan A, Worden FP, Krauss JC, Zaidi H, Frey K, Suresh K, Dewaraja YK, Wong KK
Theranostics 2024;14(9):3708-3718. Epub 2024 Jun 11 doi: 10.7150/thno.98053. PMID: 38948061Free PMC Article
Comparative study of bone mineral density, calcium, and vitamin D status in the Gujarati and white populations of Leicester.
Hamson C, Goh L, Sheldon P, Samanta A
Postgrad Med J 2003 May;79(931):279-83. doi: 10.1136/pmj.79.931.279. PMID: 12782775Free PMC Article
The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.
Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE
J Bone Miner Res 2003 Apr;18(4):615-23. doi: 10.1359/jbmr.2003.18.4.615. PMID: 12674322
Intravenously administered pamidronate in the treatment of Paget's disease of bone.
Tucci JR, Bontha S
Endocr Pract 2001 Nov-Dec;7(6):423-9. doi: 10.4158/EP.7.6.423. PMID: 11747277
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970

Prognosis

Enhancing precision: A predictive model for (177)Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative (68)Ga-DOTATATE PET and clinicopathological biomarkers.
Akhavanallaf A, Joshi S, Mohan A, Worden FP, Krauss JC, Zaidi H, Frey K, Suresh K, Dewaraja YK, Wong KK
Theranostics 2024;14(9):3708-3718. Epub 2024 Jun 11 doi: 10.7150/thno.98053. PMID: 38948061Free PMC Article
Mineral metabolism abnormalities in patients with prostate cancer: a systematic case controlled study.
Minisola F, Cipriani C, Colangelo L, Cilli M, Sciarra A, Von Heland M, Nieddu L, Anastasi E, Pascone R, Fassino V, Diacinti D, Longo F, Minisola S, Pepe J
Endocrine 2018 Feb;59(2):338-343. Epub 2017 Jun 28 doi: 10.1007/s12020-017-1351-0. PMID: 28660378
Intravenously administered pamidronate in the treatment of Paget's disease of bone.
Tucci JR, Bontha S
Endocr Pract 2001 Nov-Dec;7(6):423-9. doi: 10.4158/EP.7.6.423. PMID: 11747277
Perinatal hypophosphatasia: radiology, pathology and molecular biology studies in a family harboring a splicing mutation (648+1A) and a novel missense mutation (N400S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene.
Sergi C, Mornet E, Troeger J, Voigtlaender T
Am J Med Genet 2001 Oct 15;103(3):235-40. PMID: 11745997
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970

Clinical prediction guides

Enhancing precision: A predictive model for (177)Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative (68)Ga-DOTATATE PET and clinicopathological biomarkers.
Akhavanallaf A, Joshi S, Mohan A, Worden FP, Krauss JC, Zaidi H, Frey K, Suresh K, Dewaraja YK, Wong KK
Theranostics 2024;14(9):3708-3718. Epub 2024 Jun 11 doi: 10.7150/thno.98053. PMID: 38948061Free PMC Article
Identifying adult hypophosphatasia in the rheumatology unit.
Feurstein J, Behanova M, Haschka J, Roetzer K, Uyanik G, Hadzimuratovic B, Witsch-Baumgartner M, Schett G, Zwerina J, Kocijan R
Orphanet J Rare Dis 2022 Dec 14;17(1):435. doi: 10.1186/s13023-022-02572-7. PMID: 36514157Free PMC Article
Association between childhood atopic dermatitis, malnutrition, and low bone mineral density: a US population-based study.
Silverberg JI
Pediatr Allergy Immunol 2015 Feb;26(1):54-61. doi: 10.1111/pai.12315. PMID: 25443466
Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells.
Stein E, Koehn J, Sutter W, Wendtlandt G, Wanschitz F, Thurnher D, Baghestanian M, Turhani D
Wien Klin Wochenschr 2008;120(3-4):112-7. doi: 10.1007/s00508-008-0932-6. PMID: 18322773
Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients.
Couttenye MM, D'Haese PC, Van Hoof VO, Lemoniatou E, Goodman W, Verpooten GA, De Broe ME
Nephrol Dial Transplant 1996 Jun;11(6):1065-72. PMID: 8671970

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