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Abnormal small intestinal villus morphology

MedGen UID:: 868929
•Concept ID:: C4023341
•: Anatomical Abnormality

Synonyms:	Abnormal shape of small intestinal villus; Abnormality of small intestinal villus morphology

HPO:	HP:0011472

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal small intestinal villus morphology

Abnormality of the digestive system
- Abnormal digestive system morphology
  - Abnormal gastrointestinal tract morphology
    - Abnormal intestine morphology
      - Abnormal small intestine morphology
        Abnormal small intestinal mucosa morphology
        Abnormal small intestinal villus morphology
        Microvillar PAS-positive secretory granules
        Microvillus inclusions
        Villous atrophy

Professional guidelines

PubMed

Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.

Gwavava NJ, Pinkerton CR, Glasgow JF, Sloan JM, Bridges JM
J Clin Pathol 1981 Jul;34(7):790-5. doi: 10.1136/jcp.34.7.790. PMID: 6943149 Free PMC Article

Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management.

Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O
Cancer 1975 Apr;35(4):1167-78. doi: 10.1002/1097-0142(197504)35:4<1167::aid-cncr2820350423>3.0.co;2-y. PMID: 163677

See all (2)

Recent clinical studies

Etiology

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Israelyan N, Del Colle A, Li Z, Park Y, Xing A, Jacobsen JPR, Luna RA, Jensen DD, Madra M, Saurman V, Rahim R, Latorre R, Law K, Carson W, Bunnett NW, Caron MG, Margolis KG
Gastroenterology 2019 Aug;157(2):507-521.e4. Epub 2019 May 7 doi: 10.1053/j.gastro.2019.04.022. PMID: 31071306 Free PMC Article

Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.

Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524

Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.

Kirmizi A, Kalkan C, Yuksel S, Gencturk Z, Savas B, Soykan İ, Cetinkaya H, Ensari A
Virchows Arch 2018 Nov;473(5):551-558. Epub 2018 Aug 9 doi: 10.1007/s00428-018-2430-1. PMID: 30094491

Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.

Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636

Intestinal immune cells in Strongyloides stercoralis infection.

Trajman A, MacDonald TT, Elia CC
J Clin Pathol 1997 Dec;50(12):991-5. doi: 10.1136/jcp.50.12.991. PMID: 9516879 Free PMC Article

See all (18)

Diagnosis

Discriminant value of IEL counts and distribution pattern through the spectrum of gluten sensitivity: a simple diagnostic approach.

Kirmizi A, Kalkan C, Yuksel S, Gencturk Z, Savas B, Soykan İ, Cetinkaya H, Ensari A
Virchows Arch 2018 Nov;473(5):551-558. Epub 2018 Aug 9 doi: 10.1007/s00428-018-2430-1. PMID: 30094491

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.

Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921

Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis.

Lee SJ, Lee J, Li KK, Holland D, Maughan H, Guttman DS, Yusta B, Drucker DJ
Endocrinology 2012 Mar;153(3):1141-51. Epub 2012 Jan 17 doi: 10.1210/en.2011-1954. PMID: 22253424 Free PMC Article

Food-induced malabsorption syndromes.

Savilahti E
J Pediatr Gastroenterol Nutr 2000;30 Suppl:S61-6. doi: 10.1097/00005176-200001001-00010. PMID: 10634301

Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum.

Van Beers EH, Einerhand AW, Taminiau JA, Heymans HS, Dekker J, Büller HA
J Pediatr Gastroenterol Nutr 1998 Feb;26(2):186-93. doi: 10.1097/00005176-199802000-00013. PMID: 9481636

See all (16)

Therapy

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.

Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524

Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data.

Buchman AL
Am J Clin Nutr 2001 Jul;74(1):25-32. doi: 10.1093/ajcn/74.1.25. PMID: 11451714

Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.

Gwavava NJ, Pinkerton CR, Glasgow JF, Sloan JM, Bridges JM
J Clin Pathol 1981 Jul;34(7):790-5. doi: 10.1136/jcp.34.7.790. PMID: 6943149 Free PMC Article

Gastrointestinal complications of immunodeficiency syndromes.

Katz AJ, Rosen FS
Ciba Found Symp 1977 Apr 26-28;(46):243-61. doi: 10.1002/9780470720288.ch12. PMID: 346324

See all (18)

Prognosis

Predictors of Subsequent Celiac Disease Seropositivity in Patients Diagnosed with Duodenal Villus Atrophy on Upper Endoscopy.

Ching CK, Lyudmer M, Lewis S, Krishnareddy S, Green PHR, Lebwohl B
Dig Dis Sci 2024 Mar;69(3):876-883. Epub 2023 Dec 19 doi: 10.1007/s10620-023-08217-4. PMID: 38112838

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.

Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921

Disaccharidase activities in children: normal values and comparison based on symptoms and histologic changes.

Gupta SK, Chong SK, Fitzgerald JF
J Pediatr Gastroenterol Nutr 1999 Mar;28(3):246-51. doi: 10.1097/00005176-199903000-00007. PMID: 10067723

Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs.

Taha AS, Dahill S, Nakshabendi I, Lee FD, Sturrock RD, Russell RI
Gut 1993 Sep;34(9):1162-6. doi: 10.1136/gut.34.9.1162. PMID: 8406146 Free PMC Article

Radiation enteritis in children. A retrospective review, clinicopathologic correlation, and dietary management.

Donaldson SS, Jundt S, Ricour C, Sarrazin D, Lemerle J, Schweisguth O
Cancer 1975 Apr;35(4):1167-78. doi: 10.1002/1097-0142(197504)35:4<1167::aid-cncr2820350423>3.0.co;2-y. PMID: 163677

See all (8)

Clinical prediction guides

Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine.

Hendrickson SM, Thomas A, Prongay K, Haertel AJ, Garzel LM, Gill L, Barr T, Rhoades NS, Reader R, Galan M, Carroll JM, Roberts CT, Gao L, Amanna IJ, Messaoudi I, Slifka MK
Nat Commun 2022 Jan 11;13(1):234. doi: 10.1038/s41467-021-27925-x. PMID: 35017515 Free PMC Article

Short bowel mucosal morphology, proliferation and inflammation at first and repeat STEP procedures.

Mutanen A, Barrett M, Feng Y, Lohi J, Rabah R, Teitelbaum DH, Pakarinen MP
J Pediatr Surg 2019 Mar;54(3):511-516. Epub 2018 Apr 17 doi: 10.1016/j.jpedsurg.2018.04.016. PMID: 29753524

Measuring Change In Small Intestinal Histology In Patients With Celiac Disease.

Adelman DC, Murray J, Wu TT, Mäki M, Green PH, Kelly CP
Am J Gastroenterol 2018 Mar;113(3):339-347. Epub 2018 Feb 20 doi: 10.1038/ajg.2017.480. PMID: 29460921

Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle.

Coopersmith CM, Chandrasekaran C, McNevin MS, Gordon JI
J Cell Biol 1997 Jul 14;138(1):167-79. doi: 10.1083/jcb.138.1.167. PMID: 9214390 Free PMC Article

Ultrastructural changes in the upper small intestinal mucosa in patients with cholera.

Mathan MM, Chandy G, Mathan VI
Gastroenterology 1995 Aug;109(2):422-30. doi: 10.1016/0016-5085(95)90329-1. PMID: 7615191

See all (20)

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Abnormal small intestinal villus morphology

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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