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Abnormal lacrimal gland morphology

MedGen UID:
868924
•Concept ID:
C4023336
•
Anatomical Abnormality
Synonym: Abnormality of the lacrimal gland
 
HPO: HP:0011482

Definition

Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye. [from HPO]

Professional guidelines

PubMed

Congenital nasolacrimal duct obstruction: clinical guideline.
Sasaki T, Matsumura N, Miyazaki C, Kamao T, Yokoi N, Fujimoto M, Hayami M, Iwasaki A, Mimura M, Murata A, Nakayama T, Shinomiya K, Tanaka H, Ueta Y; Congenital Nasolacrimal Duct Obstruction: Clinical Guideline Preparation Team; Committee for Congenital Nasolacrimal Duct Obstruction Clinical Guideline
Jpn J Ophthalmol 2024 Jul;68(4):367-388. Epub 2024 Aug 16 doi: 10.1007/s10384-024-01064-4. PMID: 39150609
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article

Recent clinical studies

Etiology

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
Hemangiopericytoma of the lacrimal sac.
Charles NC, Palu RN, Jagirdar JS
Arch Ophthalmol 1998 Dec;116(12):1677-80. doi: 10.1001/archopht.116.12.1677. PMID: 9869805

Diagnosis

Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Congenital alacrima.
Zhao Z, Allen RC
Orbit 2022 Apr;41(2):162-169. Epub 2021 Sep 5 doi: 10.1080/01676830.2021.1974057. PMID: 34486478
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
The lacrimal system.
Örge FH, Boente CS
Pediatr Clin North Am 2014 Jun;61(3):529-39. doi: 10.1016/j.pcl.2014.03.002. PMID: 24852150

Therapy

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Miller MT, Ventura L, Strömland K
Birth Defects Res A Clin Mol Teratol 2009 Aug;85(8):667-76. doi: 10.1002/bdra.20609. PMID: 19639653
Eye dryness sensations after refractive surgery: impaired tear secretion or "phantom" cornea?
Belmonte C
J Refract Surg 2007 Jun;23(6):598-602. doi: 10.3928/1081-597X-20070601-11. PMID: 17598580
Eyelids, lacrimal apparatus, and conjunctiva.
Sexton RR
Arch Ophthalmol 1969 Feb;81(2):281-99. doi: 10.1001/archopht.1969.00990010283024. PMID: 4179337

Prognosis

Incidence and clinical characteristics of congenital nasolacrimal duct obstruction.
Sathiamoorthi S, Frank RD, Mohney BG
Br J Ophthalmol 2019 Apr;103(4):527-529. Epub 2018 Jun 6 doi: 10.1136/bjophthalmol-2018-312074. PMID: 29875230Free PMC Article
Dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele.
Sarbajna T, Takahashi Y, Paula Valencia MR, Ana-Magadia MG, Ishikawa E, Kakizaki H
Int J Pediatr Otorhinolaryngol 2018 Dec;115:54-57. Epub 2018 Sep 19 doi: 10.1016/j.ijporl.2018.09.017. PMID: 30368393
Proboscis lateralis.
Lelli GJ Jr, Maher EA, Milite JP, Dyleski R
Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):499-501. doi: 10.1097/IOP.0b013e31818b6e57. PMID: 19033859
Paediatric dacryocystorhinostomy.
Hakin KN, Sullivan TJ, Sharma A, Welham RA
Aust N Z J Ophthalmol 1994 Nov;22(4):231-5. doi: 10.1111/j.1442-9071.1994.tb00789.x. PMID: 7727099
Tear trough implants for correction of tear trough deformity.
Flowers RS
Clin Plast Surg 1993 Apr;20(2):403-15. PMID: 8485949

Clinical prediction guides

Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
The Etiology of Epiphora: A Multifactorial Issue.
Nemet AY
Semin Ophthalmol 2016;31(3):275-9. Epub 2014 Nov 6 doi: 10.3109/08820538.2014.962163. PMID: 25375763
Management of congenital nasolacrimal duct obstruction.
Takahashi Y, Kakizaki H, Chan WO, Selva D
Acta Ophthalmol 2010 Aug;88(5):506-13. Epub 2009 Jul 21 doi: 10.1111/j.1755-3768.2009.01592.x. PMID: 19681790
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Miller MT, Ventura L, Strömland K
Birth Defects Res A Clin Mol Teratol 2009 Aug;85(8):667-76. doi: 10.1002/bdra.20609. PMID: 19639653
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868

Recent systematic reviews

Assessing the success rate of treatment in simple and complex congenital nasolacrimal duct obstruction: a systematic review and meta-analysis.
Eshraghi B, Babaei L, Moradi M, Chaibakhsh S, Aghajani A
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):1993-2004. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06318-4. PMID: 38059998
Phenotypic spectrum of FGF10-related disorders: a systematic review.
Bzdega K, Karolak JA
PeerJ 2022;10:e14003. Epub 2022 Sep 14 doi: 10.7717/peerj.14003. PMID: 36124135Free PMC Article
Nasolacrimal Duct Probing for Young Children With Congenital Nasolacrimal Duct Obstructions in China: A 10-Year Systematic Review.
Xiang Q, Gao X, Chen X, Qi J, Fang J
J Pediatr Ophthalmol Strabismus 2019 Nov 1;56(6):365-372. doi: 10.3928/01913913-20190923-04. PMID: 31743404

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