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Abnormality of circulating fibrinogen

MedGen UID:: 868734
•Concept ID:: C4023139
•: Anatomical Abnormality

HPO:	HP:0011898

Definition

An abnormality of the level of activity of circulating fibrinogen. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormality of circulating fibrinogen

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormality of coagulation
    - Abnormality of the coagulation cascade
      - Abnormality of the common coagulation pathway
        Abnormality of circulating fibrinogen
        Afibrinogenemia
        Cryofibrinogenemia
        Dysfibrinogenemia
        Hyperfibrinogenemia
        Hypofibrinogenemia

Conditions with this feature

Ehlers-Danlos syndrome, classic-like, 3

MedGen UID:: 1861383
•Concept ID:: C5935631
•: Disease or Syndrome

Ehlers-Danlos syndrome classic-like-3 (EDSCLL3) is an autosomal dominant connective tissue disorder characterized by joint hypermobility and frequent joint dislocations, atrophic scarring, prolonged bleeding time, and age-related aortic dilatation and rupture (Hadar et al., 2024). For a discussion of genetic heterogeneity of classic-like Ehlers-Danlos syndrome, see 606408. For a discussion of the classificiation of Ehlers-Danlos syndrome, see EDSCL1 (130000).

See: Condition Record

Ehlers-Danlos syndrome, classic-like, 3

Professional guidelines

PubMed

Guideline for the use of fresh-frozen plasma. Medical Directors Advisory Committee, National Blood Transfusion Council.

S Afr Med J 1998 Oct;88(10):1344-7. PMID: 9807194

Platelets, hemostasis, and thromboembolism during treatment of acute respiratory insufficiency with extracorporeal membrane oxygenation.

Heiden D, Mielke CH Jr, Rodvien R, Hill JD
J Thorac Cardiovasc Surg 1975 Oct;70(4):644-55. PMID: 1177477

See all (2)

Recent clinical studies

Etiology

Congenital Fibrinogen Deficiency in India and Role of Human Fibrinogen Concentrate.

John MJ, Byreddy P, Modak K, Makkar M
Acta Haematol 2021;144(6):595-602. Epub 2021 Jun 4 doi: 10.1159/000516339. PMID: 34091452

Trauma-induced coagulopathy.

Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200 Free PMC Article

Platelet gene expression and function in patients with COVID-19.

Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA
Blood 2020 Sep 10;136(11):1317-1329. doi: 10.1182/blood.2020007214. PMID: 32573711 Free PMC Article

Diagnosis of congenital fibrinogen disorders.

Lebreton A, Casini A
Ann Biol Clin (Paris) 2016 Aug 1;74(4):405-12. doi: 10.1684/abc.2016.1167. PMID: 27492693

Dysfibrinogenemia and thrombosis.

Hayes T
Arch Pathol Lab Med 2002 Nov;126(11):1387-90. doi: 10.5858/2002-126-1387-DAT. PMID: 12421146

See all (144)

Diagnosis

Trauma-induced coagulopathy.

Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200 Free PMC Article

COVID-19-associated coagulopathy and disseminated intravascular coagulation.

Asakura H, Ogawa H
Int J Hematol 2021 Jan;113(1):45-57. Epub 2020 Nov 7 doi: 10.1007/s12185-020-03029-y. PMID: 33161508 Free PMC Article

Diagnosis of congenital fibrinogen disorders.

Lebreton A, Casini A
Ann Biol Clin (Paris) 2016 Aug 1;74(4):405-12. doi: 10.1684/abc.2016.1167. PMID: 27492693

Amniotic fluid embolism: update and review.

Sultan P, Seligman K, Carvalho B
Curr Opin Anaesthesiol 2016 Jun;29(3):288-96. doi: 10.1097/ACO.0000000000000328. PMID: 27153475

Idiopathic atrophie blanche.

Amato L, Chiarini C, Berti S, Massi D, Fabbri P
Skinmed 2006 May-Jun;5(3):151-4. doi: 10.1111/j.1540-9740.2006.04541.x. PMID: 16687988

See all (79)

Therapy

Congenital Fibrinogen Deficiency in India and Role of Human Fibrinogen Concentrate.

John MJ, Byreddy P, Modak K, Makkar M
Acta Haematol 2021;144(6):595-602. Epub 2021 Jun 4 doi: 10.1159/000516339. PMID: 34091452

COVID-19-associated coagulopathy and disseminated intravascular coagulation.

Asakura H, Ogawa H
Int J Hematol 2021 Jan;113(1):45-57. Epub 2020 Nov 7 doi: 10.1007/s12185-020-03029-y. PMID: 33161508 Free PMC Article

Update on massive transfusion.

Pham HP, Shaz BH
Br J Anaesth 2013 Dec;111 Suppl 1:i71-82. doi: 10.1093/bja/aet376. PMID: 24335401

Idiopathic atrophie blanche.

Amato L, Chiarini C, Berti S, Massi D, Fabbri P
Skinmed 2006 May-Jun;5(3):151-4. doi: 10.1111/j.1540-9740.2006.04541.x. PMID: 16687988

Inhibitors to clotting factors.

Sallah S
Ann Hematol 1997 Jul-Aug;75(1-2):1-7. doi: 10.1007/s002770050305. PMID: 9322677

See all (98)

Prognosis

Analysis of the levels of inflammatory parameters in persons over the age of 90.

Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278

COVID-19-associated coagulopathy and disseminated intravascular coagulation.

Asakura H, Ogawa H
Int J Hematol 2021 Jan;113(1):45-57. Epub 2020 Nov 7 doi: 10.1007/s12185-020-03029-y. PMID: 33161508 Free PMC Article

Platelet gene expression and function in patients with COVID-19.

Diagnosis of congenital fibrinogen disorders.

Lebreton A, Casini A
Ann Biol Clin (Paris) 2016 Aug 1;74(4):405-12. doi: 10.1684/abc.2016.1167. PMID: 27492693

Amniotic fluid embolism: update and review.

Sultan P, Seligman K, Carvalho B
Curr Opin Anaesthesiol 2016 Jun;29(3):288-96. doi: 10.1097/ACO.0000000000000328. PMID: 27153475

See all (67)

Clinical prediction guides

Analysis of the levels of inflammatory parameters in persons over the age of 90.

Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278

Diagnosis of congenital fibrinogen disorders.

Lebreton A, Casini A
Ann Biol Clin (Paris) 2016 Aug 1;74(4):405-12. doi: 10.1684/abc.2016.1167. PMID: 27492693

Fibrinogen and red blood cells in venous thrombosis.

Aleman MM, Walton BL, Byrnes JR, Wolberg AS
Thromb Res 2014 May;133 Suppl 1(0 1):S38-40. doi: 10.1016/j.thromres.2014.03.017. PMID: 24759140 Free PMC Article

Idiopathic atrophie blanche.

Amato L, Chiarini C, Berti S, Massi D, Fabbri P
Skinmed 2006 May-Jun;5(3):151-4. doi: 10.1111/j.1540-9740.2006.04541.x. PMID: 16687988

Disseminated intravascular coagulation.

Fruchtman S, Aledort LM
J Am Coll Cardiol 1986 Dec;8(6 Suppl B):159B-167B. doi: 10.1016/s0735-1097(86)80017-1. PMID: 3537068

See all (114)

Recent systematic reviews

Predictors of adverse prognosis in COVID-19: A systematic review and meta-analysis.

Figliozzi S, Masci PG, Ahmadi N, Tondi L, Koutli E, Aimo A, Stamatelopoulos K, Dimopoulos MA, Caforio ALP, Georgiopoulos G
Eur J Clin Invest 2020 Oct;50(10):e13362. Epub 2020 Aug 27 doi: 10.1111/eci.13362. PMID: 32726868

See all (1)

MedGen

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Abnormality of circulating fibrinogen

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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