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Abnormal mitochondrial number

MedGen UID:
868642
Concept ID:
C4023043
Anatomical Abnormality
HPO: HP:0012102

Definition

A deviation from the normal number of mitochondria per cell. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Nishikawa H, Fukunishi S, Asai A, Yokohama K, Nishiguchi S, Higuchi K
Int J Mol Med 2021 Aug;48(2) Epub 2021 Jun 29 doi: 10.3892/ijmm.2021.4989. PMID: 34184088
Pafili K, Roden M
Mol Metab 2021 Aug;50:101122. Epub 2020 Nov 19 doi: 10.1016/j.molmet.2020.101122. PMID: 33220492Free PMC Article
McCormick E, Place E, Falk MJ
Neurotherapeutics 2013 Apr;10(2):251-61. doi: 10.1007/s13311-012-0174-1. PMID: 23269497Free PMC Article

Recent clinical studies

Etiology

Fink JK
Handb Clin Neurol 2023;196:59-88. doi: 10.1016/B978-0-323-98817-9.00022-3. PMID: 37620092
Karali M, Testa F, Di Iorio V, Torella A, Zeuli R, Scarpato M, Romano F, Onore ME, Pizzo M, Melillo P, Brunetti-Pierri R, Passerini I, Pelo E, Cremers FPM, Esposito G, Nigro V, Simonelli F, Banfi S
Sci Rep 2022 Dec 2;12(1):20815. doi: 10.1038/s41598-022-24636-1. PMID: 36460718Free PMC Article
Pafili K, Roden M
Mol Metab 2021 Aug;50:101122. Epub 2020 Nov 19 doi: 10.1016/j.molmet.2020.101122. PMID: 33220492Free PMC Article
Phan THG, Paliogiannis P, Nasrallah GK, Giordo R, Eid AH, Fois AG, Zinellu A, Mangoni AA, Pintus G
Cell Mol Life Sci 2021 Mar;78(5):2031-2057. Epub 2020 Nov 17 doi: 10.1007/s00018-020-03693-7. PMID: 33201251Free PMC Article
Lynch DS, Wade C, Paiva ARB, John N, Kinsella JA, Merwick Á, Ahmed RM, Warren JD, Mummery CJ, Schott JM, Fox NC, Houlden H, Adams ME, Davagnanam I, Murphy E, Chataway J
J Neurol Neurosurg Psychiatry 2019 May;90(5):543-554. Epub 2018 Nov 22 doi: 10.1136/jnnp-2018-319481. PMID: 30467211Free PMC Article

Diagnosis

Fink JK
Handb Clin Neurol 2023;196:59-88. doi: 10.1016/B978-0-323-98817-9.00022-3. PMID: 37620092
Karali M, Testa F, Di Iorio V, Torella A, Zeuli R, Scarpato M, Romano F, Onore ME, Pizzo M, Melillo P, Brunetti-Pierri R, Passerini I, Pelo E, Cremers FPM, Esposito G, Nigro V, Simonelli F, Banfi S
Sci Rep 2022 Dec 2;12(1):20815. doi: 10.1038/s41598-022-24636-1. PMID: 36460718Free PMC Article
Friedman JM, van Essen P, van Karnebeek CDM
Mol Genet Metab 2022 Dec;137(4):399-419. Epub 2021 Nov 8 doi: 10.1016/j.ymgme.2021.11.001. PMID: 34872807
Lynch DS, Wade C, Paiva ARB, John N, Kinsella JA, Merwick Á, Ahmed RM, Warren JD, Mummery CJ, Schott JM, Fox NC, Houlden H, Adams ME, Davagnanam I, Murphy E, Chataway J
J Neurol Neurosurg Psychiatry 2019 May;90(5):543-554. Epub 2018 Nov 22 doi: 10.1136/jnnp-2018-319481. PMID: 30467211Free PMC Article
Saleem S, Aslam HM, Anwar M, Anwar S, Saleem M, Saleem A, Rehmani MA
Orphanet J Rare Dis 2013 Oct 8;8:156. doi: 10.1186/1750-1172-8-156. PMID: 24098952Free PMC Article

Therapy

Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV
J Gerontol A Biol Sci Med Sci 2023 Jan 26;78(1):75-89. doi: 10.1093/gerona/glac135. PMID: 35975308Free PMC Article
Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D, Piao HL, Liu HX
Theranostics 2021;11(10):4839-4857. Epub 2021 Mar 4 doi: 10.7150/thno.56747. PMID: 33754031Free PMC Article
Phan THG, Paliogiannis P, Nasrallah GK, Giordo R, Eid AH, Fois AG, Zinellu A, Mangoni AA, Pintus G
Cell Mol Life Sci 2021 Mar;78(5):2031-2057. Epub 2020 Nov 17 doi: 10.1007/s00018-020-03693-7. PMID: 33201251Free PMC Article
Lin X, Dai Y, Tong X, Xu W, Huang Q, Jin X, Li C, Zhou F, Zhou H, Lin X, Huang D, Zhang S
Redox Biol 2020 Feb;30:101431. Epub 2020 Jan 12 doi: 10.1016/j.redox.2020.101431. PMID: 31972508Free PMC Article
Thakur K, Tomar SK, Singh AK, Mandal S, Arora S
Crit Rev Food Sci Nutr 2017 Nov 22;57(17):3650-3660. doi: 10.1080/10408398.2016.1145104. PMID: 27029320

Prognosis

Vasileva Z
Folia Med (Plovdiv) 2021 Dec 31;63(6):827-833. doi: 10.3897/folmed.63.e58637. PMID: 35851222
Qiao L, Xu L, Yu L, Wynn J, Hernan R, Zhou X, Farkouh-Karoleski C, Krishnan US, Khlevner J, De A, Zygmunt A, Crombleholme T, Lim FY, Needelman H, Cusick RA, Mychaliska GB, Warner BW, Wagner AJ, Danko ME, Chung D, Potoka D, Kosiński P, McCulley DJ, Elfiky M, Azarow K, Fialkowski E, Schindel D, Soffer SZ, Lyon JB, Zalieckas JM, Vardarajan BN, Aspelund G, Duron VP, High FA, Sun X, Donahoe PK, Shen Y, Chung WK
Am J Hum Genet 2021 Oct 7;108(10):1964-1980. Epub 2021 Sep 20 doi: 10.1016/j.ajhg.2021.08.011. PMID: 34547244Free PMC Article
Nishikawa H, Fukunishi S, Asai A, Yokohama K, Nishiguchi S, Higuchi K
Int J Mol Med 2021 Aug;48(2) Epub 2021 Jun 29 doi: 10.3892/ijmm.2021.4989. PMID: 34184088
Alexiou A, Nizami B, Khan FI, Soursou G, Vairaktarakis C, Chatzichronis S, Tsiamis V, Manztavinos V, Yarla NS, Md Ashraf G
Curr Protein Pept Sci 2018;19(9):850-857. doi: 10.2174/1389203718666170810150151. PMID: 28799502
Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC; NCI CPTAC
Nature 2014 Sep 18;513(7518):382-7. Epub 2014 Jul 20 doi: 10.1038/nature13438. PMID: 25043054Free PMC Article

Clinical prediction guides

Robinson GA, Wilkinson MGL, Wincup C
Front Immunol 2021;12:806560. Epub 2022 Jan 26 doi: 10.3389/fimmu.2021.806560. PMID: 35154082Free PMC Article
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, Zimmerman AW
Proc Natl Acad Sci U S A 2014 Oct 28;111(43):15550-5. Epub 2014 Oct 13 doi: 10.1073/pnas.1416940111. PMID: 25313065Free PMC Article
Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC; NCI CPTAC
Nature 2014 Sep 18;513(7518):382-7. Epub 2014 Jul 20 doi: 10.1038/nature13438. PMID: 25043054Free PMC Article

Recent systematic reviews

Frye RE, Rincon N, McCarty PJ, Brister D, Scheck AC, Rossignol DA
Neurobiol Dis 2024 Jul;197:106520. Epub 2024 May 3 doi: 10.1016/j.nbd.2024.106520. PMID: 38703861
Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF
J Am Soc Nephrol 2023 Nov 1;34(11):1875-1888. Epub 2023 Sep 6 doi: 10.1681/ASN.0000000000000224. PMID: 37678265Free PMC Article
Popova D, Bhide P, D'Antonio F, Basnet P, Acharya G
BJOG 2022 Aug;129(9):1434-1446. Epub 2022 Jan 18 doi: 10.1111/1471-0528.17078. PMID: 34954901
Gupta D, Hull ML, Fraser I, Miller L, Bossuyt PM, Johnson N, Nisenblat V
Cochrane Database Syst Rev 2016 Apr 20;4(4):CD012165. doi: 10.1002/14651858.CD012165. PMID: 27094925Free PMC Article
Prince M, Christensen E, Gluud C
Cochrane Database Syst Rev 2005 Apr 18;2005(2):CD003778. doi: 10.1002/14651858.CD003778.pub2. PMID: 15846681Free PMC Article

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