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Decreased sialylation of N-linked protein glycosylation

MedGen UID:
868542
Concept ID:
C4022941
Finding
HPO: HP:0012350

Definition

Decreased addition of sialic acids to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased sialylation of N-linked protein glycosylation

Professional guidelines

PubMed

Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

Wojcik I, Wuhrer M, Heeringa P, Stegeman CA, Rutgers A, Falck D
Front Immunol 2023;14:1214945. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1214945. PMID: 37841251Free PMC Article
Montasser ME, Van Hout CV, Miloscio L, Howard AD, Rosenberg A, Callaway M, Shen B, Li N, Locke AE, Verweij N, De T, Ferreira MA, Lotta LA, Baras A, Daly TJ, Hartford SA, Lin W, Mao Y, Ye B, White D, Gong G, Perry JA, Ryan KA, Fang Q, Tzoneva G, Pefanis E, Hunt C, Tang Y, Lee L; Regeneron Genetics Center Collaboration‡, Sztalryd-Woodle C, Mitchell BD, Healy M, Streeten EA, Taylor SI, O'Connell JR, Economides AN, Della Gatta G, Shuldiner AR
Science 2021 Dec 3;374(6572):1221-1227. Epub 2021 Dec 2 doi: 10.1126/science.abe0348. PMID: 34855475
Twisselmann N, Bartsch YC, Pagel J, Wieg C, Hartz A, Ehlers M, Härtel C
Front Immunol 2018;9:3166. Epub 2019 Jan 18 doi: 10.3389/fimmu.2018.03166. PMID: 30713537Free PMC Article
Qin Y, Zhong Y, Ma T, Zhang J, Yang G, Guan F, Li Z, Li B
Glycoconj J 2017 Aug;34(4):523-535. Epub 2017 Apr 8 doi: 10.1007/s10719-017-9768-5. PMID: 28389847
Dennis JW
Semin Cancer Biol 1991 Dec;2(6):411-20. PMID: 1810469

Diagnosis

Wojcik I, Schmidt DE, de Neef LA, Rab MAE, Meek B, de Weerdt O, Wuhrer M, van der Schoot CE, Zwaginga JJ, de Haas M, Falck D, Vidarsson G
Sci Rep 2021 Dec 15;11(1):24045. doi: 10.1038/s41598-021-03196-w. PMID: 34911982Free PMC Article
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Melo-Braga MN, Ibáñez-Vea M, Larsen MR, Kulej K
Methods Mol Biol 2015;1295:275-92. doi: 10.1007/978-1-4939-2550-6_21. PMID: 25820729
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article
Lublin DM, Krsek-Staples J, Pangburn MK, Atkinson JP
J Immunol 1986 Sep 1;137(5):1629-35. PMID: 2427577

Therapy

Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Duarte HO, Rodrigues JG, Gomes C, Hensbergen PJ, Ederveen ALH, de Ru AH, Mereiter S, Polónia A, Fernandes E, Ferreira JA, van Veelen PA, Santos LL, Wuhrer M, Gomes J, Reis CA
Oncogene 2021 May;40(21):3719-3733. Epub 2021 May 4 doi: 10.1038/s41388-021-01801-w. PMID: 33947960Free PMC Article
Zhong X, Jagarlapudi S, Weng Y, Ly M, Rouse JC, McClure K, Ishino T, Zhang Y, Sousa E, Cohen J, Tzvetkova B, Cote K, Scarcelli JJ, Johnson K, Palandra J, Apgar JR, Yaddanapudi S, Gonzalez-Villalobos RA, Opsahl AC, Lam K, Yao Q, Duan W, Sievers A, Zhou J, Ferguson D, D'Antona A, Zollner R, Zhu HL, Kriz R, Lin L, Clerin V
J Biol Chem 2020 Mar 6;295(10):3115-3133. Epub 2020 Jan 31 doi: 10.1074/jbc.RA119.012144. PMID: 32005658Free PMC Article
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article
Dennis JW
Semin Cancer Biol 1991 Dec;2(6):411-20. PMID: 1810469

Prognosis

Wojcik I, Wuhrer M, Heeringa P, Stegeman CA, Rutgers A, Falck D
Front Immunol 2023;14:1214945. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1214945. PMID: 37841251Free PMC Article
Lloyd KA, Steen J, Amara K, Titcombe PJ, Israelsson L, Lundström SL, Zhou D, Zubarev RA, Reed E, Piccoli L, Gabay C, Lanzavecchia A, Baeten D, Lundberg K, Mueller DL, Klareskog L, Malmström V, Grönwall C
Eur J Immunol 2018 Jun;48(6):1030-1045. Epub 2018 Apr 6 doi: 10.1002/eji.201747446. PMID: 29512823
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Arnold JN, Saldova R, Galligan MC, Murphy TB, Mimura-Kimura Y, Telford JE, Godwin AK, Rudd PM
J Proteome Res 2011 Apr 1;10(4):1755-64. Epub 2011 Mar 16 doi: 10.1021/pr101034t. PMID: 21214223

Clinical prediction guides

Wojcik I, Schmidt DE, de Neef LA, Rab MAE, Meek B, de Weerdt O, Wuhrer M, van der Schoot CE, Zwaginga JJ, de Haas M, Falck D, Vidarsson G
Sci Rep 2021 Dec 15;11(1):24045. doi: 10.1038/s41598-021-03196-w. PMID: 34911982Free PMC Article
Lloyd KA, Steen J, Amara K, Titcombe PJ, Israelsson L, Lundström SL, Zhou D, Zubarev RA, Reed E, Piccoli L, Gabay C, Lanzavecchia A, Baeten D, Lundberg K, Mueller DL, Klareskog L, Malmström V, Grönwall C
Eur J Immunol 2018 Jun;48(6):1030-1045. Epub 2018 Apr 6 doi: 10.1002/eji.201747446. PMID: 29512823
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article
de Jong G, van Noort WL, Feelders RA, de Jeu-Jaspars CM, van Eijk HG
Clin Chim Acta 1992 Nov 16;212(1-2):27-45. doi: 10.1016/0009-8981(92)90135-d. PMID: 1486679

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