U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased sialylation of N-linked protein glycosylation

MedGen UID:
868541
Concept ID:
C4022940
Finding
HPO: HP:0012351

Definition

Increased addition of sialic acids to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased sialylation of N-linked protein glycosylation

Professional guidelines

PubMed

Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
Montasser ME, Van Hout CV, Miloscio L, Howard AD, Rosenberg A, Callaway M, Shen B, Li N, Locke AE, Verweij N, De T, Ferreira MA, Lotta LA, Baras A, Daly TJ, Hartford SA, Lin W, Mao Y, Ye B, White D, Gong G, Perry JA, Ryan KA, Fang Q, Tzoneva G, Pefanis E, Hunt C, Tang Y, Lee L; Regeneron Genetics Center Collaboration‡, Sztalryd-Woodle C, Mitchell BD, Healy M, Streeten EA, Taylor SI, O'Connell JR, Economides AN, Della Gatta G, Shuldiner AR
Science 2021 Dec 3;374(6572):1221-1227. Epub 2021 Dec 2 doi: 10.1126/science.abe0348. PMID: 34855475
Keser T, Tijardović M, Gornik I, Lukić E, Lauc G, Gornik O, Novokmet M
Mol Cell Proteomics 2021;20:100044. Epub 2021 Jan 23 doi: 10.1074/mcp.RA120.002433. PMID: 33493676Free PMC Article
Li X, Raihan MA, Reynoso FJ, He M
Curr Protoc Hum Genet 2015 Jul 1;86:17.18.1-17.18.22. doi: 10.1002/0471142905.hg1718s86. PMID: 26132001
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article

Diagnosis

Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel PM, Mehta AS, Lewin DN, Haab BB, Drake RR
Mol Cell Proteomics 2021;20:100012. Epub 2020 Dec 8 doi: 10.1074/mcp.RA120.002256. PMID: 33581409Free PMC Article
Li X, Raihan MA, Reynoso FJ, He M
Curr Protoc Hum Genet 2015 Jul 1;86:17.18.1-17.18.22. doi: 10.1002/0471142905.hg1718s86. PMID: 26132001
Arnold JN, Saldova R, Hamid UM, Rudd PM
Proteomics 2008 Aug;8(16):3284-93. doi: 10.1002/pmic.200800163. PMID: 18646009

Therapy

Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Teare JM, Kates DS, Shah A, Garger S
Drug Des Devel Ther 2019;13:941-948. Epub 2019 Mar 22 doi: 10.2147/DDDT.S188171. PMID: 30962676Free PMC Article
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article
Bork K, Horstkorte R, Weidemann W
J Pharm Sci 2009 Oct;98(10):3499-508. doi: 10.1002/jps.21684. PMID: 19199295

Prognosis

Keser T, Tijardović M, Gornik I, Lukić E, Lauc G, Gornik O, Novokmet M
Mol Cell Proteomics 2021;20:100044. Epub 2021 Jan 23 doi: 10.1074/mcp.RA120.002433. PMID: 33493676Free PMC Article
Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, Gudelj I, Gašparović H, Biočina B, Tilin T, Wennerström A, Männistö S, Salomaa V, Havulinna A, Wang W, Wilson JF, Chaturvedi N, Perola M, Campbell H, Lauc G, Gornik O
Diabetologia 2017 Dec;60(12):2352-2360. Epub 2017 Sep 13 doi: 10.1007/s00125-017-4426-9. PMID: 28905229
Sonneveld ME, Koelewijn J, de Haas M, Admiraal J, Plomp R, Koeleman CA, Hipgrave Ederveen AL, Ligthart P, Wuhrer M, van der Schoot CE, Vidarsson G
Br J Haematol 2017 Feb;176(4):651-660. Epub 2016 Nov 28 doi: 10.1111/bjh.14438. PMID: 27891581
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Gornik O, Royle L, Harvey DJ, Radcliffe CM, Saldova R, Dwek RA, Rudd P, Lauc G
Glycobiology 2007 Dec;17(12):1321-32. Epub 2007 Oct 15 doi: 10.1093/glycob/cwm106. PMID: 17940056

Clinical prediction guides

Fastenau C, Bunce M, Keating M, Wickline J, Hopp SC, Bieniek KF
Brain Pathol 2024 Jul;34(4):e13267. Epub 2024 May 9 doi: 10.1111/bpa.13267. PMID: 38724175Free PMC Article
Lai JD, Swystun LL, Cartier D, Nesbitt K, Zhang C, Hough C, Dennis JW, Lillicrap D
Haematologica 2018 Nov;103(11):1925-1936. Epub 2018 Jul 12 doi: 10.3324/haematol.2018.188219. PMID: 30002126Free PMC Article
O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS
J Thromb Haemost 2016 Dec;14(12):2446-2457. Epub 2016 Dec 9 doi: 10.1111/jth.13537. PMID: 27732771
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...