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Decreased fucosylation of N-linked protein glycosylation

MedGen UID:
868539
Concept ID:
C4022938
Finding
HPO: HP:0012353

Definition

Decreased addition of fucose sugar units to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased fucosylation of N-linked protein glycosylation

Professional guidelines

PubMed

Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

Leprovost S, Plasson C, Balieu J, Walet-Balieu ML, Lerouge P, Bardor M, Mathieu-Rivet E
Plant Biotechnol J 2024 Nov;22(11):3018-3027. Epub 2024 Jul 5 doi: 10.1111/pbi.14424. PMID: 38968612
Wojcik I, Wuhrer M, Heeringa P, Stegeman CA, Rutgers A, Falck D
Front Immunol 2023;14:1214945. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1214945. PMID: 37841251Free PMC Article
Qin Y, Zhong Y, Ma T, Zhang J, Yang G, Guan F, Li Z, Li B
Glycoconj J 2017 Aug;34(4):523-535. Epub 2017 Apr 8 doi: 10.1007/s10719-017-9768-5. PMID: 28389847
Comunale MA, Wang M, Rodemich-Betesh L, Hafner J, Lamontagne A, Klein A, Marrero J, Di Bisceglie AM, Gish R, Block T, Mehta A
Cancer Epidemiol Biomarkers Prev 2011 Jun;20(6):1222-9. Epub 2011 Apr 5 doi: 10.1158/1055-9965.EPI-10-1047. PMID: 21467232Free PMC Article
Arnold JN, Saldova R, Galligan MC, Murphy TB, Mimura-Kimura Y, Telford JE, Godwin AK, Rudd PM
J Proteome Res 2011 Apr 1;10(4):1755-64. Epub 2011 Mar 16 doi: 10.1021/pr101034t. PMID: 21214223

Diagnosis

Wojcik I, Schmidt DE, de Neef LA, Rab MAE, Meek B, de Weerdt O, Wuhrer M, van der Schoot CE, Zwaginga JJ, de Haas M, Falck D, Vidarsson G
Sci Rep 2021 Dec 15;11(1):24045. doi: 10.1038/s41598-021-03196-w. PMID: 34911982Free PMC Article
Shu J, Yu H, Du H, Zhang J, Zhang K, Li X, Xie H, Li Z
Cancer Biomark 2018;22(4):669-681. doi: 10.3233/CBM-171087. PMID: 29865036
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O
Glycobiology 2012 Jul;22(7):975-82. Epub 2012 Mar 16 doi: 10.1093/glycob/cws062. PMID: 22426998
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Therapy

Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Höti N, Yang S, Hu Y, Shah P, Haffner MC, Zhang H
Prostate Cancer Prostatic Dis 2018 Apr;21(1):137-146. Epub 2018 Jan 16 doi: 10.1038/s41391-017-0016-7. PMID: 29339807Free PMC Article
Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Prognosis

Wojcik I, Wuhrer M, Heeringa P, Stegeman CA, Rutgers A, Falck D
Front Immunol 2023;14:1214945. Epub 2023 Sep 29 doi: 10.3389/fimmu.2023.1214945. PMID: 37841251Free PMC Article
Yun R, Hong E, Kim J, Park B, Kim SJ, Lee B, Song YS, Kim SJ, Park S, Kang JM
Cell Death Dis 2023 Aug 23;14(8):546. doi: 10.1038/s41419-023-06083-6. PMID: 37612293Free PMC Article
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Kapur R, Della Valle L, Sonneveld M, Hipgrave Ederveen A, Visser R, Ligthart P, de Haas M, Wuhrer M, van der Schoot CE, Vidarsson G
Br J Haematol 2014 Sep;166(6):936-45. Epub 2014 Jun 7 doi: 10.1111/bjh.12965. PMID: 24909983Free PMC Article

Clinical prediction guides

Golay J, Andrea AE, Cattaneo I
Front Immunol 2022;13:929895. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.929895. PMID: 35844552Free PMC Article
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O
Glycobiology 2012 Jul;22(7):975-82. Epub 2012 Mar 16 doi: 10.1093/glycob/cws062. PMID: 22426998
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

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