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Increased fucosylation of N-linked protein glycosylation

MedGen UID:
868538
•Concept ID:
C4022937
•
Finding
HPO: HP:0012354

Definition

Increased addition of fucose sugar units to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased fucosylation of N-linked protein glycosylation

Professional guidelines

PubMed

Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment.
Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
Comparative analysis of the human serum N-glycome in lung cancer, COPD and their comorbidity using capillary electrophoresis.
Mészáros B, Járvás G, Farkas A, Szigeti M, Kovács Z, Kun R, Szabó M, Csánky E, Guttman A
J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jan 15;1137:121913. Epub 2019 Dec 12 doi: 10.1016/j.jchromb.2019.121913. PMID: 31881512
A pilot study of salivary N-glycome in HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma.
Qin Y, Zhong Y, Ma T, Zhang J, Yang G, Guan F, Li Z, Li B
Glycoconj J 2017 Aug;34(4):523-535. Epub 2017 Apr 8 doi: 10.1007/s10719-017-9768-5. PMID: 28389847
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article
Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue.
Mehta A, Norton P, Liang H, Comunale MA, Wang M, Rodemich-Betesh L, Koszycki A, Noda K, Miyoshi E, Block T
Cancer Epidemiol Biomarkers Prev 2012 Jun;21(6):925-33. Epub 2012 Apr 6 doi: 10.1158/1055-9965.EPI-11-1183. PMID: 22490318Free PMC Article

Diagnosis

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2.
Kanto N, Ohkawa Y, Kitano M, Maeda K, Shiida M, Ono T, Ota F, Kizuka Y, Kunimasa K, Nishino K, Mukai M, Seike M, Azuma A, Harada Y, Fukuda T, Gu J, Taniguchi N
J Biol Chem 2023 Dec;299(12):105365. Epub 2023 Oct 20 doi: 10.1016/j.jbc.2023.105365. PMID: 37865317Free PMC Article
N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes.
DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS
Mol Cancer Res 2021 Nov;19(11):1868-1877. Epub 2021 Aug 11 doi: 10.1158/1541-7786.MCR-21-0348. PMID: 34380744Free PMC Article
Changes in plasma and IgG N-glycome during childhood and adolescence.
Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O
Glycobiology 2012 Jul;22(7):975-82. Epub 2012 Mar 16 doi: 10.1093/glycob/cws062. PMID: 22426998
Fucosylated glycoproteins as markers of liver disease.
Mehta A, Block TM
Dis Markers 2008;25(4-5):259-65. doi: 10.1155/2008/264594. PMID: 19126969Free PMC Article

Therapy

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
The "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity.
Pereira NA, Chan KF, Lin PC, Song Z
MAbs 2018 Jul;10(5):693-711. doi: 10.1080/19420862.2018.1466767. PMID: 29733746Free PMC Article
Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells.
Razaghi A, Villacrés C, Jung V, Mashkour N, Butler M, Owens L, Heimann K
Exp Cell Res 2017 Oct 1;359(1):20-29. Epub 2017 Aug 10 doi: 10.1016/j.yexcr.2017.08.014. PMID: 28803068
N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients.
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Prognosis

Release of urinary extracellular vesicles in prostate cancer is associated with altered urinary N-glycosylation profile.
Vermassen T, D'Herde K, Jacobus D, Van Praet C, Poelaert F, Lumen N, Callewaert N, Decaestecker K, Villeirs G, Hoebeke P, Van Belle S, Rottey S, Delanghe J
J Clin Pathol 2017 Oct;70(10):838-846. Epub 2017 Mar 30 doi: 10.1136/jclinpath-2016-204312. PMID: 28360190
Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn.
Sonneveld ME, Koelewijn J, de Haas M, Admiraal J, Plomp R, Koeleman CA, Hipgrave Ederveen AL, Ligthart P, Wuhrer M, van der Schoot CE, Vidarsson G
Br J Haematol 2017 Feb;176(4):651-660. Epub 2016 Nov 28 doi: 10.1111/bjh.14438. PMID: 27891581
Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia.
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma.
Bartling B, Vanhooren V, Dewaele S, Libert C, Hofmann HS, Haerting J, Nuding S, Silber RE, Simm A, Chen CC
Cancer Biomark 2011-2012;10(3-4):145-54. doi: 10.3233/CBM-2012-0239. PMID: 22674300

Clinical prediction guides

A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2.
Kanto N, Ohkawa Y, Kitano M, Maeda K, Shiida M, Ono T, Ota F, Kizuka Y, Kunimasa K, Nishino K, Mukai M, Seike M, Azuma A, Harada Y, Fukuda T, Gu J, Taniguchi N
J Biol Chem 2023 Dec;299(12):105365. Epub 2023 Oct 20 doi: 10.1016/j.jbc.2023.105365. PMID: 37865317Free PMC Article
Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article
Changes in plasma and IgG N-glycome during childhood and adolescence.
Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O
Glycobiology 2012 Jul;22(7):975-82. Epub 2012 Mar 16 doi: 10.1093/glycob/cws062. PMID: 22426998
Fucosylated glycoproteins as markers of liver disease.
Mehta A, Block TM
Dis Markers 2008;25(4-5):259-65. doi: 10.1155/2008/264594. PMID: 19126969Free PMC Article

Recent systematic reviews

Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review.
Norton PA, Mehta AS
World J Gastroenterol 2019 Jun 21;25(23):2947-2960. doi: 10.3748/wjg.v25.i23.2947. PMID: 31249452Free PMC Article

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