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Abnormal distal femoral metaphysis morphology

MedGen UID:: 868136
•Concept ID:: C4022527
•: Anatomical Abnormality

Synonyms:	Abnormality of wide portion of outermost thighbone; Distal femoral metaphyseal abnormality

HPO:	HP:0030299

Definition

An anomaly of the metaphysis of the distal femur (close to the knee). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal distal femoral metaphysis morphology

Phenotypic abnormality
- Abnormality of limbs
  - Abnormality of the lower limb
    - Abnormal lower-limb metaphysis morphology
      - Abnormal femoral metaphysis morphology
        Abnormal distal femoral metaphysis morphology
        Wide distal femoral metaphysis

Recent clinical studies

Etiology

Segmental torsion assessment is a reliable method for in-depth analysis of femoral alignment in Computer Tomography.

Ferlic PW, Runer A, Seeber C, Thöni M, Seitlinger G, Liebensteiner MC
Int Orthop 2018 Jun;42(6):1227-1231. Epub 2017 Aug 14 doi: 10.1007/s00264-017-3598-8. PMID: 28808753

Distal Femoral Cortical Irregularity in children.

Muramatsu K, Tominaga Y, Hashimoto T, Taguchi T
Acta Orthop Belg 2015 Sep;81(3):392-7. PMID: 26435232

Derotational femoral osteotomy technique with locking nail fixation for adolescent femoral antetorsion: surgical technique and preliminary study.

Pailhé R, Bedes L, Sales de Gauzy J, Tran R, Cavaignac E, Accadbled F
J Pediatr Orthop B 2014 Nov;23(6):523-8. doi: 10.1097/BPB.0000000000000087. PMID: 25153645

The Erlenmeyer flask bone deformity in the skeletal dysplasias.

Faden MA, Krakow D, Ezgu F, Rimoin DL, Lachman RS
Am J Med Genet A 2009 Jun;149A(6):1334-45. doi: 10.1002/ajmg.a.32253. PMID: 19444897 Free PMC Article

Osteopenia after osteotomy of the tibia.

Finsen V
Calcif Tissue Int 1988 Jan;42(1):1-4. doi: 10.1007/BF02555831. PMID: 3129162

See all (15)

Diagnosis

Distal Femoral Cortical Irregularity in children.

Muramatsu K, Tominaga Y, Hashimoto T, Taguchi T
Acta Orthop Belg 2015 Sep;81(3):392-7. PMID: 26435232

Epithelioid hemangioma of distal femoral epiphysis in a patient with congenital talipes equinovarus.

Mridha AR, Kinra P, Sable M, Sharma MC, Rastogi S, Khan SA, Gamanagatti S
Malays J Pathol 2014 Apr;36(1):63-6. PMID: 24763238

MRI of pediatric patients: Part 2, normal variants and abnormalities of the knee.

Thapa MM, Chaturvedi A, Iyer RS, Darling SE, Khanna PC, Ishak G, Chew FS
AJR Am J Roentgenol 2012 May;198(5):W456-65. doi: 10.2214/AJR.10.7317. PMID: 22528927

Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.

Pobirci DD, Bogdan F, Pobirci O, Petcu CA, Roşca E
Rom J Morphol Embryol 2011;52(1 Suppl):385-8. PMID: 21424079

Bilateral discoid medial menisci.

Pinar H, Akseki D, Karaoğlan O, Ozkan M, Uluç E
Arthroscopy 2000 Jan-Feb;16(1):96-101. doi: 10.1016/s0749-8063(00)90135-x. PMID: 10627353

See all (11)

Therapy

Evaluating growth failure with diffusion tensor imaging in pediatric survivors of high-risk neuroblastoma treated with high-dose cis-retinoic acid.

Delgado J, Jaramillo D, Chauvin NA, Guo M, Stratton MS, Sweeney HE, Barrera CA, Mostoufi-Moab S
Pediatr Radiol 2019 Jul;49(8):1056-1065. Epub 2019 May 4 doi: 10.1007/s00247-019-04409-1. PMID: 31055614 Free PMC Article

FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH.

Yuan Q, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B
J Bone Miner Res 2011 Sep;26(9):2026-35. doi: 10.1002/jbmr.433. PMID: 21590742 Free PMC Article

Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta.

Land C, Rauch F, Glorieux FH
J Bone Miner Res 2006 Mar;21(3):374-9. Epub 2005 Dec 19 doi: 10.1359/JBMR.051207. PMID: 16491284

Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance.

Chan Y, Li C, Chu WC, Pang L, Cheng JC, Chik KW
AJR Am J Roentgenol 2000 Dec;175(6):1561-6. doi: 10.2214/ajr.175.6.1751561. PMID: 11090375

Osteopenia after osteotomy of the tibia.

Finsen V
Calcif Tissue Int 1988 Jan;42(1):1-4. doi: 10.1007/BF02555831. PMID: 3129162

See all (5)

Prognosis

Rapidly growing giant cell tumor of bone in a skeletally immature girl.

Akaike G, Ueno T, Matsumoto S, Motoi N, Matsueda K
Skeletal Radiol 2016 Apr;45(4):567-73. Epub 2015 Nov 20 doi: 10.1007/s00256-015-2276-4. PMID: 26585568

Distal Femoral Cortical Irregularity in children.

Muramatsu K, Tominaga Y, Hashimoto T, Taguchi T
Acta Orthop Belg 2015 Sep;81(3):392-7. PMID: 26435232

Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.

Pobirci DD, Bogdan F, Pobirci O, Petcu CA, Roşca E
Rom J Morphol Embryol 2011;52(1 Suppl):385-8. PMID: 21424079

Niu J, Feng G, Kong X, Wang J, Han P
J Huazhong Univ Sci Technolog Med Sci 2007 Oct;27(5):617-21. doi: 10.1007/s11596-007-0537-8. PMID: 18060651

Lengthening for congenital short femur. Results of different methods.

Grill F, Dungl P
J Bone Joint Surg Br 1991 May;73(3):439-47. doi: 10.1302/0301-620X.73B3.1670446. PMID: 1670446

See all (8)

Clinical prediction guides

Morphogenesis of the femur at different stages of normal human development.

Suzuki Y, Matsubayashi J, Ji X, Yamada S, Yoneyama A, Imai H, Matsuda T, Aoyama T, Takakuwa T
PLoS One 2019;14(8):e0221569. Epub 2019 Aug 23 doi: 10.1371/journal.pone.0221569. PMID: 31442281 Free PMC Article

Evaluating growth failure with diffusion tensor imaging in pediatric survivors of high-risk neuroblastoma treated with high-dose cis-retinoic acid.

Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.

Pobirci DD, Bogdan F, Pobirci O, Petcu CA, Roşca E
Rom J Morphol Embryol 2011;52(1 Suppl):385-8. PMID: 21424079

Niu J, Feng G, Kong X, Wang J, Han P
J Huazhong Univ Sci Technolog Med Sci 2007 Oct;27(5):617-21. doi: 10.1007/s11596-007-0537-8. PMID: 18060651

Flattening of the distal femoral epiphyses in the trichorhinophalangeal syndrome.

Schlesinger AE, Poznanski AK
Pediatr Radiol 1986;16(6):498-500. doi: 10.1007/BF02387965. PMID: 3774395

See all (8)