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Abnormal saccule morphology

MedGen UID:: 868042
•Concept ID:: C4022433
•: Anatomical Abnormality

Synonym:	Morphological abnormality of the saccule

HPO:	HP:0040110

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal saccule morphology

Ear malformation
- Abnormal ear morphology
  - Abnormality of the inner ear
    - Abnormal inner ear morphology
      - Abnormal morphology of the vestibule of the inner ear
        Abnormal semicircular canal morphology
        Abnormal saccule morphology

Professional guidelines

PubMed

Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature.

Mous DS, Kool HM, Burgisser PE, Buscop-van Kempen MJ, Nagata K, Boerema-de Munck A, van Rosmalen J, Dzyubachyk O, Wijnen RMH, Tibboel D, Rottier RJ
Am J Physiol Lung Cell Mol Physiol 2018 Aug 1;315(2):L276-L285. Epub 2018 May 10 doi: 10.1152/ajplung.00392.2017. PMID: 29745254

Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer.

Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB
Ann Intern Med 1999 Aug 17;131(4):247-55. doi: 10.7326/0003-4819-131-4-199908170-00003. PMID: 10454945

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Recent clinical studies

Etiology

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Peripheral vestibular pathology in Mondini dysplasia.

Kaya S, Hızlı Ö, Kaya FK, Monsanto RD, Paparella MM, Cureoglu S
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Interaural difference values of vestibular evoked myogenic.

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Inherited hearing defects in mice.

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Annu Rev Genet 1995;29:675-701. doi: 10.1146/annurev.ge.29.120195.003331. PMID: 8825490

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Diagnosis

Clinical features of otolith organ-specific vestibular dysfunction.

Fujimoto C, Suzuki S, Kinoshita M, Egami N, Sugasawa K, Iwasaki S
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Bilateral combined laryngocele.

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Therapy

Laryngocele: a rare long-term complication following neck surgery?

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Responses of the ear to low frequency sounds, infrasound and wind turbines.

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Vestibular evoked myogenic potentials in acute acoustic trauma.

Wang YP, Hsu WC, Young YH
Otol Neurotol 2006 Oct;27(7):956-61. doi: 10.1097/01.mao.0000231590.57348.4b. PMID: 17006346

Effect of prenatal glucocorticoids on pulmonary vascular muscularisation in nitrofen-induced congenital diaphragmatic hernia.

Okoye BO, Losty PD, Lloyd DA, Gosney JR
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Intracranial myospherulosis.

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Prognosis

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The laryngeal saccule: clinical significance.

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Fatal asphyxia due to laryngomucocele.

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Schubert MC, Minor LB
Phys Ther 2004 Apr;84(4):373-85. PMID: 15049730

Asymptomatic bilateral mixed-type laryngocele and laryngeal carcinoma.

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Clinical prediction guides

The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans.

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Arch Toxicol 2023 Jul;97(7):1943-1961. Epub 2023 May 17 doi: 10.1007/s00204-023-03518-z. PMID: 37195449 Free PMC Article

Temporal Bone Histopathology in Cockayne Syndrome.

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Otol Neurotol 2018 Jun;39(5):e387-e391. doi: 10.1097/MAO.0000000000001801. PMID: 29649050 Free PMC Article

Fatal asphyxia due to laryngomucocele.

Töro K, Kardos M, Dunay G
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Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.

Morsli H, Tuorto F, Choo D, Postiglione MP, Simeone A, Wu DK
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