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EMG: impaired neuromuscular transmission

MedGen UID:: 867778
•Concept ID:: C4022168
•: Finding

HPO:	HP:0100285

Definition

An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP). [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEMG: impaired neuromuscular transmission

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the musculature
    - Abnormal muscle physiology
      - EMG abnormality
        EMG: impaired neuromuscular transmission
        EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
        EMG: incremental response of compound muscle action potential to repetitive nerve stimulation

Recent clinical studies

Etiology

Neuromuscular impairment at different stages of human sarcopenia.

Sarto F, Franchi MV, McPhee JS, Stashuk DW, Paganini M, Monti E, Rossi M, Sirago G, Zampieri S, Motanova ES, Valli G, Moro T, Paoli A, Bottinelli R, Pellegrino MA, De Vito G, Blau HM, Narici MV
J Cachexia Sarcopenia Muscle 2024 Oct;15(5):1797-1810. Epub 2024 Sep 5 doi: 10.1002/jcsm.13531. PMID: 39236304 Free PMC Article

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Impaired neuromuscular transmission after recovery of the train-of-four ratio.

Eikermann M, Gerwig M, Hasselmann C, Fiedler G, Peters J
Acta Anaesthesiol Scand 2007 Feb;51(2):226-34. doi: 10.1111/j.1399-6576.2006.01228.x. PMID: 17261149

Pre- and post-synaptic abnormalities associated with impaired neuromuscular transmission in a group of patients with 'limb-girdle myasthenia'.

Slater CR, Fawcett PR, Walls TJ, Lyons PR, Bailey SJ, Beeson D, Young C, Gardner-Medwin D
Brain 2006 Aug;129(Pt 8):2061-76. doi: 10.1093/brain/awl200. PMID: 16870884

Single fibre EMG findings in polyneuropathies of different aetiology.

Thiele B, Stålberg E
J Neurol Neurosurg Psychiatry 1975 Sep;38(9):881-7. doi: 10.1136/jnnp.38.9.881. PMID: 171347 Free PMC Article

See all (29)

Diagnosis

Neuromuscular impairment at different stages of human sarcopenia.

Normal and abnormal voluntary activity.

Rubin DI
Handb Clin Neurol 2019;160:281-301. doi: 10.1016/B978-0-444-64032-1.00018-7. PMID: 31277854

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Dysphagia as the sole manifestation of myasthenia gravis.

Llabrés M, Molina-Martinez FJ, Miralles F
J Neurol Neurosurg Psychiatry 2005 Sep;76(9):1297-300. doi: 10.1136/jnnp.2004.038430. PMID: 16107373 Free PMC Article

Multiple sclerosis with impaired neuromuscular transmission.

Chaco J
Confin Neurol 1974;36(3):182-5. doi: 10.1159/000102793. PMID: 4376477

See all (29)

Therapy

Pyrostigmine therapy in a patient with VAMP1-related congenital myasthenic syndrome.

Al-Muhaizea MA, AlQuait L, AlRasheed A, AlHarbi S, Albader AA, AlMass R, Albakheet A, Alhumaidan A, AlRasheed MM, Colak D, Kaya N
Neuromuscul Disord 2020 Jul;30(7):611-615. Epub 2020 May 15 doi: 10.1016/j.nmd.2020.04.007. PMID: 32616363

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

Impaired neuromuscular transmission and response to acetylcholinesterase inhibitors in centronuclear myopathies.

Robb SA, Sewry CA, Dowling JJ, Feng L, Cullup T, Lillis S, Abbs S, Lees MM, Laporte J, Manzur AY, Knight RK, Mills KR, Pike MG, Kress W, Beeson D, Jungbluth H, Pitt MC, Muntoni F
Neuromuscul Disord 2011 Jun;21(6):379-86. Epub 2011 Mar 25 doi: 10.1016/j.nmd.2011.02.012. PMID: 21440438

Impaired neuromuscular transmission after recovery of the train-of-four ratio.

Eikermann M, Gerwig M, Hasselmann C, Fiedler G, Peters J
Acta Anaesthesiol Scand 2007 Feb;51(2):226-34. doi: 10.1111/j.1399-6576.2006.01228.x. PMID: 17261149

Neuromuscular transmission in migraine: a single-fiber EMG study in clinical subgroups.

Ambrosini A, Maertens de Noordhout A, Schoenen J
Neurology 2001 Apr 24;56(8):1038-43. doi: 10.1212/wnl.56.8.1038. PMID: 11320175

See all (25)

Prognosis

Normal and abnormal voluntary activity.

Rubin DI
Handb Clin Neurol 2019;160:281-301. doi: 10.1016/B978-0-444-64032-1.00018-7. PMID: 31277854

Neuromusculoskeletal Model Calibration Significantly Affects Predicted Knee Contact Forces for Walking.

Serrancolí G, Kinney AL, Fregly BJ, Font-Llagunes JM
J Biomech Eng 2016 Aug 1;138(8):0810011-08100111. doi: 10.1115/1.4033673. PMID: 27210105 Free PMC Article

Rehabilitation strategies for wrist sensorimotor control impairment: From theory to practice.

Karagiannopoulos C, Michlovitz S
J Hand Ther 2016 Apr-Jun;29(2):154-65. Epub 2015 Dec 12 doi: 10.1016/j.jht.2015.12.003. PMID: 26774958

Monitoring of neuromuscular function.

Ali HH
Int J Clin Monit Comput 1987;4(3):185-9. doi: 10.1007/BF02915906. PMID: 2821137

Single fiber EMG and cardiovascular reflexes in botulism: a follow-up study.

Vita G, Girlanda P, Russo P, Scuderi D, Puglisi RM, Marabello L
Ital J Neurol Sci 1986 Feb;7(1):71-5. doi: 10.1007/BF02230420. PMID: 3957635

See all (13)

Clinical prediction guides

Neuromuscular impairment at different stages of human sarcopenia.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Inns TB, Bass JJ, Hardy EJO, Wilkinson DJ, Stashuk DW, Atherton PJ, Phillips BE, Piasecki M
J Physiol 2022 Nov;600(21):4753-4769. Epub 2022 Oct 5 doi: 10.1113/JP283425. PMID: 36088611 Free PMC Article

Effects of short-term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile.

Sarto F, Stashuk DW, Franchi MV, Monti E, Zampieri S, Valli G, Sirago G, Candia J, Hartnell LM, Paganini M, McPhee JS, De Vito G, Ferrucci L, Reggiani C, Narici MV
J Physiol 2022 Nov;600(21):4731-4751. Epub 2022 Sep 27 doi: 10.1113/JP283381. PMID: 36071599 Free PMC Article

Neuromusculoskeletal Model Calibration Significantly Affects Predicted Knee Contact Forces for Walking.

Serrancolí G, Kinney AL, Fregly BJ, Font-Llagunes JM
J Biomech Eng 2016 Aug 1;138(8):0810011-08100111. doi: 10.1115/1.4033673. PMID: 27210105 Free PMC Article

Monitoring of neuromuscular function.

Ali HH
Int J Clin Monit Comput 1987;4(3):185-9. doi: 10.1007/BF02915906. PMID: 2821137

See all (25)

Recent systematic reviews

Congenital myasthenic syndromes.

Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424 Free PMC Article

See all (1)

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EMG: impaired neuromuscular transmission

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

Related information

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