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Abnormal femur morphology

MedGen UID:
867385
•Concept ID:
C4021750
•
Anatomical Abnormality
Synonym: Abnormality of femur morphology
 
HPO: HP:0002823

Definition

Any anomaly of the structure of the femur. [from HPO]

Professional guidelines

PubMed

Society for Maternal-Fetal Medicine Consult Series #57: Evaluation and management of isolated soft ultrasound markers for aneuploidy in the second trimester: (Replaces Consults #10, Single umbilical artery, October 2010; #16, Isolated echogenic bowel diagnosed on second-trimester ultrasound, August 2011; #17, Evaluation and management of isolated renal pelviectasis on second-trimester ultrasound, December 2011; #25, Isolated fetal choroid plexus cysts, April 2013; #27, Isolated echogenic intracardiac focus, August 2013).
Society for Maternal-Fetal Medicine (SMFM). Electronic address: [email protected], Prabhu M, Kuller JA, Biggio JR
Am J Obstet Gynecol 2021 Oct;225(4):B2-B15. Epub 2021 Jun 23 doi: 10.1016/j.ajog.2021.06.079. PMID: 34171388
Prenatal diagnosis of proximal focal femoral deficiency: Literature review of prenatal sonographic findings.
D'Ambrosio V, Pasquali G, Squarcella A, Marcoccia E, De Filippis A, Gatto S, Camilla A, Pizzuti A, La Torre R, Giancotti A
J Clin Ultrasound 2016 May;44(4):252-9. Epub 2015 Sep 26 doi: 10.1002/jcu.22306. PMID: 26408260
Osteonecrosis of the femoral head: evaluation and treatment.
Zalavras CG, Lieberman JR
J Am Acad Orthop Surg 2014 Jul;22(7):455-64. doi: 10.5435/JAAOS-22-07-455. PMID: 24966252

Recent clinical studies

Etiology

Is the Citak classification of distal femur morphology age and gender dependent?
Dasci MF, Kose O, Budin M, Kara S, Gehrke T, Citak M
Arch Orthop Trauma Surg 2023 Nov;143(11):6773-6779. Epub 2023 Jul 4 doi: 10.1007/s00402-023-04959-y. PMID: 37400672
Midtrimester isolated short femur and perinatal outcomes: A systematic review and meta-analysis.
D'Ambrosio V, Vena F, Marchetti C, Di Mascio D, Perrone S, Boccherini C, Pizzuti A, Benedetti Panici P, Giancotti A
Acta Obstet Gynecol Scand 2019 Jan;98(1):11-17. Epub 2018 Oct 31 doi: 10.1111/aogs.13470. PMID: 30252939
Femoroacetabular impingement: role of imaging.
Genovese E, Spiga S, Vinci V, Aliprandi A, Di Pietto F, Coppolino F, Scialpi M, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S117-26. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0283-y. PMID: 23949933
Cam impingement of the hip: a risk factor for hip osteoarthritis.
Agricola R, Waarsing JH, Arden NK, Carr AJ, Bierma-Zeinstra SM, Thomas GE, Weinans H, Glyn-Jones S
Nat Rev Rheumatol 2013 Oct;9(10):630-4. Epub 2013 Jul 23 doi: 10.1038/nrrheum.2013.114. PMID: 23881070
Outcomes after trochleoplasty.
Faruqui S, Bollier M, Wolf B, Amendola N
Iowa Orthop J 2012;32:196-206. PMID: 23576941Free PMC Article

Diagnosis

Growth Modulation in Achondroplasia.
McClure PK, Kilinc E, Birch JG
J Pediatr Orthop 2017 Sep;37(6):e384-e387. doi: 10.1097/BPO.0000000000001045. PMID: 28719547
Trochlear dysplasia and the role of trochleoplasty.
LaPrade RF, Cram TR, James EW, Rasmussen MT
Clin Sports Med 2014 Jul;33(3):531-45. Epub 2014 May 24 doi: 10.1016/j.csm.2014.03.005. PMID: 24993414
Femoroacetabular impingement: role of imaging.
Genovese E, Spiga S, Vinci V, Aliprandi A, Di Pietto F, Coppolino F, Scialpi M, Giganti M
Musculoskelet Surg 2013 Aug;97 Suppl 2:S117-26. Epub 2013 Aug 15 doi: 10.1007/s12306-013-0283-y. PMID: 23949933
Cam morphology in the human hip.
Ng VY, Ellis TJ
Orthopedics 2012 Apr;35(4):320-7. doi: 10.3928/01477447-20120327-10. PMID: 22495842
Torsional and angular deformities.
Bruce RW Jr
Pediatr Clin North Am 1996 Aug;43(4):867-81. doi: 10.1016/s0031-3955(05)70439-9. PMID: 8692584

Therapy

Is the Citak classification of distal femur morphology age and gender dependent?
Dasci MF, Kose O, Budin M, Kara S, Gehrke T, Citak M
Arch Orthop Trauma Surg 2023 Nov;143(11):6773-6779. Epub 2023 Jul 4 doi: 10.1007/s00402-023-04959-y. PMID: 37400672
Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts.
Chen K, Liu Y, He J, Pavlos N, Wang C, Kenny J, Yuan J, Zhang Q, Xu J, He W
Int J Biol Sci 2020;16(11):1888-1900. Epub 2020 Apr 6 doi: 10.7150/ijbs.40917. PMID: 32398957Free PMC Article
Midtrimester isolated short femur and perinatal outcomes: A systematic review and meta-analysis.
D'Ambrosio V, Vena F, Marchetti C, Di Mascio D, Perrone S, Boccherini C, Pizzuti A, Benedetti Panici P, Giancotti A
Acta Obstet Gynecol Scand 2019 Jan;98(1):11-17. Epub 2018 Oct 31 doi: 10.1111/aogs.13470. PMID: 30252939
Femoroacetabular Impingement: A Review.
Egger AC, Frangiamore S, Rosneck J
Sports Med Arthrosc Rev 2016 Dec;24(4):e53-e58. doi: 10.1097/JSA.0000000000000126. PMID: 27811519
Shwachman-Diamond syndrome.
Dall'oca C, Bondi M, Merlini M, Cipolli M, Lavini F, Bartolozzi P
Musculoskelet Surg 2012 Aug;96(2):81-8. Epub 2011 Dec 27 doi: 10.1007/s12306-011-0174-z. PMID: 22201042

Prognosis

Congenital Tibial Deficiency.
Litrenta J, Young M, Birch JG, Oetgen ME
J Am Acad Orthop Surg 2019 Mar 15;27(6):e268-e279. doi: 10.5435/JAAOS-D-16-00838. PMID: 30418269
Prenatal diagnosis of proximal focal femoral deficiency: Literature review of prenatal sonographic findings.
D'Ambrosio V, Pasquali G, Squarcella A, Marcoccia E, De Filippis A, Gatto S, Camilla A, Pizzuti A, La Torre R, Giancotti A
J Clin Ultrasound 2016 May;44(4):252-9. Epub 2015 Sep 26 doi: 10.1002/jcu.22306. PMID: 26408260
Hip dysplasia in the skeletally mature patient.
Goldstein RY, Kaye ID, Slover J, Feldman D
Bull Hosp Jt Dis (2013) 2014;72(1):28-42. PMID: 25150325
Patellofemoral imaging.
Merchant AC
Clin Orthop Relat Res 2001 Aug;(389):15-21. doi: 10.1097/00003086-200108000-00004. PMID: 11501803
Kyphomelic dysplasia.
Temple IK, Thompson EM, Hall CM, Bridgeman G, Pembrey ME
J Med Genet 1989 Jul;26(7):457-61. doi: 10.1136/jmg.26.7.457. PMID: 2746619Free PMC Article

Clinical prediction guides

Congenital Tibial Deficiency.
Litrenta J, Young M, Birch JG, Oetgen ME
J Am Acad Orthop Surg 2019 Mar 15;27(6):e268-e279. doi: 10.5435/JAAOS-D-16-00838. PMID: 30418269
Femoral lengthening in children and adolescents.
Pejin Z
Orthop Traumatol Surg Res 2017 Feb;103(1S):S143-S149. Epub 2017 Jan 16 doi: 10.1016/j.otsr.2016.05.020. PMID: 28110891
Hip dysplasia in the skeletally mature patient.
Goldstein RY, Kaye ID, Slover J, Feldman D
Bull Hosp Jt Dis (2013) 2014;72(1):28-42. PMID: 25150325
Torsional and angular deformities.
Bruce RW Jr
Pediatr Clin North Am 1996 Aug;43(4):867-81. doi: 10.1016/s0031-3955(05)70439-9. PMID: 8692584
Torsional deformity.
Staheli LT
Pediatr Clin North Am 1986 Dec;33(6):1373-83. doi: 10.1016/s0031-3955(16)36148-x. PMID: 3786004

Recent systematic reviews

Midtrimester isolated short femur and perinatal outcomes: A systematic review and meta-analysis.
D'Ambrosio V, Vena F, Marchetti C, Di Mascio D, Perrone S, Boccherini C, Pizzuti A, Benedetti Panici P, Giancotti A
Acta Obstet Gynecol Scand 2019 Jan;98(1):11-17. Epub 2018 Oct 31 doi: 10.1111/aogs.13470. PMID: 30252939
Trochleoplasty techniques provide good clinical results in patients with trochlear dysplasia.
Longo UG, Vincenzo C, Mannering N, Ciuffreda M, Salvatore G, Berton A, Denaro V
Knee Surg Sports Traumatol Arthrosc 2018 Sep;26(9):2640-2658. Epub 2017 May 31 doi: 10.1007/s00167-017-4584-9. PMID: 28567511
What Is the Association Between Sports Participation and the Development of Proximal Femoral Cam Deformity? A Systematic Review and Meta-analysis.
Nepple JJ, Vigdorchik JM, Clohisy JC
Am J Sports Med 2015 Nov;43(11):2833-40. Epub 2015 Jan 13 doi: 10.1177/0363546514563909. PMID: 25587186
Clinical outcome scores for arthroscopic femoral osteochondroplasty in femoroacetabular impingement: a quantitative systematic review.
Gillespie JA, Patil SR, Meek RD
Scott Med J 2015 Feb;60(1):13-22. Epub 2014 Nov 26 doi: 10.1177/0036933014560300. PMID: 25428942
Hip ontogenesis: how evolution, genes, and load history shape hip morphotype and cartilotype.
Hogervorst T, Eilander W, Fikkers JT, Meulenbelt I
Clin Orthop Relat Res 2012 Dec;470(12):3284-96. doi: 10.1007/s11999-012-2511-4. PMID: 22926490Free PMC Article

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