U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal 3rd finger morphology

MedGen UID:
867319
•Concept ID:
C4021682
•
Anatomical Abnormality
Synonyms: Abnormality of the 3rd finger; Abnormality of the middle finger
 
HPO: HP:0004150

Definition

An anomaly of the third finger. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal 3rd finger morphology

Conditions with this feature

Mesoaxial hexadactyly and cardiac malformation
MedGen UID:
167099
•Concept ID:
C0796057
•
Disease or Syndrome
A syndrome of mental retardation, short stature, delayed puberty, polydactyly, synmetracarpalia, ocular torticollis, orofacial dysmorphism, and multiple cardiac malformations.
See: Condition Record
Mesoaxial hexadactyly and cardiac malformation

Recent clinical studies

Etiology

Microduplication of Xq24 and Hartsfield syndrome with holoprosencephaly, ectrodactyly, and clefting.
Takenouchi T, Okuno H, Kosaki R, Ariyasu D, Torii C, Momoshima S, Harada N, Yoshihashi H, Takahashi T, Awazu M, Kosaki K
Am J Med Genet A 2012 Oct;158A(10):2537-41. Epub 2012 Aug 10 doi: 10.1002/ajmg.a.35465. PMID: 22887648
Normative data for anthropometric parameters used in delineation of dysmorphic features in north Indian children.
Kapoor S, Bhuhsan S, Ghosh VB, Pandey RM, Kalaivani M
Indian J Pediatr 2012 May;79(5):619-31. Epub 2011 Nov 9 doi: 10.1007/s12098-011-0572-0. PMID: 22069166
Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
Functional and morphological evaluation of hand microcirculation with nailfold capillaroscopy and laser Doppler imaging in Raynaud's and Sjögren's syndrome and poly/dermatomyositis.
Szabo N, Csiki Z, Szanto A, Danko K, Szodoray P, Zeher M
Scand J Rheumatol 2008 Jan-Feb;37(1):23-9. doi: 10.1080/03009740701640209. PMID: 18189191
A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome.
Milone G, Conti L, Rizzo R, Sanfilippo S, Sammito V, Romano C
Am J Med Genet 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116. PMID: 3177443

Diagnosis

Poland's syndrome with unusual hand and chest anomalies: a rare case report.
Yadav GK, Lal S, Dange N, Marwah KG, Singh JP
Indian J Chest Dis Allied Sci 2014 Jul-Sep;56(3):191-4. PMID: 25823118
Char syndrome, a familial form of patent ductus arteriosus, with a new finding: hypoplasia [corrected] of the 3rd finger.
Babaoğlu K, Oruç M, Günlemez A, Gelb BD
Anadolu Kardiyol Derg 2012 Sep;12(6):523-4. Epub 2012 Jun 22 doi: 10.5152/akd.2012.165. PMID: 22728731
A case with de novo interstitial deletion of chromosome 7q21.1-q22.
Manguoğlu E, Berker-Karaüzüm S, Baumer A, Mihçi E, Taçoy S, Lüleci G, Schinzel A
Genet Couns 2005;16(2):155-9. PMID: 16080295
Gonadal agenesis in a 46,XY female with multiple malformations and positive testing for the sex-determining region of the Y chromosome.
Sorgo W, Gortner L, Bartmann P, Streb HP, Oberhoffer R, Teller WM, Zachmann M, Heymer B, Graf M, Lattermann U
Horm Res 1991;35(3-4):124-31. doi: 10.1159/000181887. PMID: 1806465
A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome.
Milone G, Conti L, Rizzo R, Sanfilippo S, Sammito V, Romano C
Am J Med Genet 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116. PMID: 3177443

Therapy

Olmsted syndrome.
Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790
Multiple malformations in a male and maternal osteopathia strata with cranial sclerosis (OSCS).
Rott HD, Krieg P, Rütschle H, Kraus C
Genet Couns 2003;14(3):281-8. PMID: 14577672
Hydrocephalus and abnormal digits after failed first-trimester prostaglandin abortion attempt.
Collins FS, Mahoney MJ
J Pediatr 1983 Apr;102(4):620-1. doi: 10.1016/s0022-3476(83)80204-2. PMID: 6572713
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

Autosomal dominant syndrome of camptodactyly, clinodactyly, syndactyly, and bifid toes.
Malik S, Afzal M, Gul S, Wahab A, Ahmad M
Am J Med Genet A 2010 Sep;152A(9):2313-7. doi: 10.1002/ajmg.a.33552. PMID: 20683984
A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome.
Milone G, Conti L, Rizzo R, Sanfilippo S, Sammito V, Romano C
Am J Med Genet 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116. PMID: 3177443

Clinical prediction guides

Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis.
Naredo E, D'Agostino MA, Terslev L, Pineda C, Miguel MI, Blasi J, Bruyn GA, Kortekaas MC, Mandl P, Nestorova R, Szkudlarek M, Todorov P, Vlad V, Wong P, Bakewell C, Filippucci E, Zabotti A, Micu M, Vreju F, Mortada M, Mendonça JA, Guillen-Astete CA, Olivas-Vergara O, Iagnocco A, Hanova P, Tinazzi I, Balint PV, Aydin SZ, Kane D, Keen H, Kaeley GS, Möller I
Ann Rheum Dis 2024 Jul 15;83(8):1060-1071. doi: 10.1136/ard-2023-225278. PMID: 38531611
Cartilage evaluation in finger joints in healthy controls and early hand osteoarthritis patients using high-resolution MRI.
Saltzherr MS, Muradin GSR, Haugen IK, Selles RW, van Neck JW, Coert JH, Hazes JMW, Luime JJ
Osteoarthritis Cartilage 2019 Aug;27(8):1148-1151. Epub 2019 May 18 doi: 10.1016/j.joca.2019.05.003. PMID: 31108225
Epidemiological analysis of rare polydactylies.
Castilla EE, Lugarinho da Fonseca R, da Graca Dutra M, Bermejo E, Cuevas L, Martínez-Frías ML
Am J Med Genet 1996 Nov 11;65(4):295-303. doi: 10.1002/(SICI)1096-8628(19961111)65:4<295::AID-AJMG10>3.0.CO;2-P. PMID: 8923939
A dermatoglyphic study of a group of Sicilian children with fragile-X syndrome.
Milone G, Conti L, Rizzo R, Sanfilippo S, Sammito V, Romano C
Am J Med Genet 1988 May-Jun;30(1-2):177-83. doi: 10.1002/ajmg.1320300116. PMID: 3177443
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...