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Abnormal 4th finger morphology

MedGen UID:
867317
•Concept ID:
C4021680
•
Anatomical Abnormality
Synonyms: Abnormality of the 4th finger; Abnormality of the ring finger
 
HPO: HP:0004188

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal 4th finger morphology

Professional guidelines

PubMed

Identification of a novel mutation of NOG in family with proximal symphalangism and early genetic counseling.
Ma C, Liu L, Wang FN, Tian HS, Luo Y, Yu R, Fan LL, Li YL
BMC Med Genet 2019 Nov 6;20(1):169. doi: 10.1186/s12881-019-0917-5. PMID: 31694554Free PMC Article

Recent clinical studies

Etiology

2D/4D Finger Length Ratio in the Screening of Developmental Dysplasia of the Hip.
Korucu IH, Duman N
J Coll Physicians Surg Pak 2024 May;34(5):600-603. doi: 10.29271/jcpsp.2024.05.600. PMID: 38720223
On-top plasty using a free metacarpal head graft for lengthening of proximal phalanx in symbrachydactyly--a case report.
Iba K, Wada T, Yamashita T
Hand Surg 2013;18(2):273-5. doi: 10.1142/S0218810413720192. PMID: 24164137
"Dangerous" anatomic varieties of recurrent motor branch of median nerve.
Elsaftawy A, Gworys B, Jabłecki J, Szajerka T
Pol Przegl Chir 2013 Aug;85(8):419-23. doi: 10.2478/pjs-2013-0064. PMID: 24009051
Evaluation of qualitative methods for phenotyping brachymesophalangia-V from radiographs of children.
Williams KD, Nahhas RW, Cottom CR, Lawrence S, Subedi J, Jha B, Czerwinski SA, Blangero J, Williams-Blangero S, Towne B
Am J Hum Biol 2012 Jan-Feb;24(1):68-73. Epub 2011 Dec 1 doi: 10.1002/ajhb.22205. PMID: 22131202Free PMC Article
Extra phenotypic features in a girl with Miller syndrome.
Al Kaissi A, Roetzer KM, Ulz P, Heitzer E, Klaushofer K, Grill F
Clin Dysmorphol 2011 Apr;20(2):66-72. doi: 10.1097/MCD.0b013e3283416701. PMID: 21346561

Diagnosis

Ophthalmo-acromelic syndrome in an infant.
Ürel-Demir G, Taşkıran EZ, Akgün-Doğan Ö, Şimşek-Kiper PÖ, Utine GE
Eur J Med Genet 2019 Jul;62(7):103664. Epub 2019 May 5 doi: 10.1016/j.ejmg.2019.05.003. PMID: 31067494
Extra phenotypic features in a girl with Miller syndrome.
Al Kaissi A, Roetzer KM, Ulz P, Heitzer E, Klaushofer K, Grill F
Clin Dysmorphol 2011 Apr;20(2):66-72. doi: 10.1097/MCD.0b013e3283416701. PMID: 21346561
Oculo-dento-digital dysplasia: lack of genotype-phenotype correlation for GJA1 mutations and usefulness of neuro-imaging.
Alao MJ, Bonneau D, Holder-Espinasse M, Goizet C, Manouvrier-Hanu S, Mezel A, Petit F, Subtil D, Magdelaine C, Lacombe D
Eur J Med Genet 2010 Jan-Feb;53(1):19-22. Epub 2009 Oct 4 doi: 10.1016/j.ejmg.2009.08.007. PMID: 19808103
MR imaging of ligaments and triangular fibrocartilage complex of the wrist.
Zlatkin MB, Rosner J
Magn Reson Imaging Clin N Am 2004 May;12(2):301-31, vi-vii. doi: 10.1016/j.mric.2004.02.012. PMID: 15172388
Dysplastic features, growth retardation, malrotation of the gut, and fatal ventricular septal defect in a 4-month-old girl with ring chromosome 15.
Otto J, Back E, Fürste HO, Abel M, Böhm N, Pringsheim W
Eur J Pediatr 1984 Aug;142(3):229-31. doi: 10.1007/BF00442457. PMID: 6468449

Therapy

Abnormal layering of muscularis propria as a cause of chronic intestinal pseudo-obstruction: A case report and literature review.
Angkathunyakul N, Treepongkaruna S, Molagool S, Ruangwattanapaisarn N
World J Gastroenterol 2015 Jun 14;21(22):7059-64. doi: 10.3748/wjg.v21.i22.7059. PMID: 26078585Free PMC Article
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Olmsted syndrome.
Ali ME, Sikdar AU, Akhtar N, Islam ZM
Mymensingh Med J 2007 Jan;16(1):100-3. doi: 10.3329/mmj.v16i1.262. PMID: 17344790
Hydrocephalus and abnormal digits after failed first-trimester prostaglandin abortion attempt.
Collins FS, Mahoney MJ
J Pediatr 1983 Apr;102(4):620-1. doi: 10.1016/s0022-3476(83)80204-2. PMID: 6572713
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Prognosis

A fetal case of microphthalmia and limb anomalies with abnormal neuronal migration associated with SMOC1 biallelic variants.
Mancini C, Zonta A, Botta G, Breda Klobus A, Valbonesi S, Pasini B, Giorgio E, Viora E, Brusco A, Brussino A
Eur J Med Genet 2019 Nov;62(11):103578. Epub 2018 Nov 13 doi: 10.1016/j.ejmg.2018.11.012. PMID: 30445150
The prevalence of the extensor digitorum communis tendon and its insertion variants: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 Nov;27(8):1284-90. Epub 2014 Jun 23 doi: 10.1002/ca.22429. PMID: 24953717
On-top plasty using a free metacarpal head graft for lengthening of proximal phalanx in symbrachydactyly--a case report.
Iba K, Wada T, Yamashita T
Hand Surg 2013;18(2):273-5. doi: 10.1142/S0218810413720192. PMID: 24164137
A case with mosaic partial duplication of 1q: prenatal and postmortem clinical and cytogenetic evaluations.
Karaoguz MY, Biri A, Pala E, Kan D, Poyraz A, Kurdoglu M, Percin EF
Genet Couns 2006;17(2):197-204. PMID: 16970038

Clinical prediction guides

2D/4D Finger Length Ratio in the Screening of Developmental Dysplasia of the Hip.
Korucu IH, Duman N
J Coll Physicians Surg Pak 2024 May;34(5):600-603. doi: 10.29271/jcpsp.2024.05.600. PMID: 38720223
Metal ring on 4th or 5th finger markedly increases both cardiac troponin I at left ventricle and cancer-related parameters such as oncogen C-fosAb2 & integrin α₅β₁[corrected] by 4-12 times. Thus these metal rings appear to promote both heart problems & cancer.
Omura Y, Hines H, Jones M, O'Young B, Duvvi H, Lu DP, Pallos A, Shimotsuura Y, Ohki M
Acupunct Electrother Res 2010;35(1-2):45-69. doi: 10.3727/036012910803860977. PMID: 20578646
Oculo-dento-digital dysplasia: lack of genotype-phenotype correlation for GJA1 mutations and usefulness of neuro-imaging.
Alao MJ, Bonneau D, Holder-Espinasse M, Goizet C, Manouvrier-Hanu S, Mezel A, Petit F, Subtil D, Magdelaine C, Lacombe D
Eur J Med Genet 2010 Jan-Feb;53(1):19-22. Epub 2009 Oct 4 doi: 10.1016/j.ejmg.2009.08.007. PMID: 19808103
Epidemiological analysis of rare polydactylies.
Castilla EE, Lugarinho da Fonseca R, da Graca Dutra M, Bermejo E, Cuevas L, Martínez-Frías ML
Am J Med Genet 1996 Nov 11;65(4):295-303. doi: 10.1002/(SICI)1096-8628(19961111)65:4<295::AID-AJMG10>3.0.CO;2-P. PMID: 8923939
Limb anomalies in chromosomal aberrations.
Pfeiffer RA, Santelmann R
Birth Defects Orig Artic Ser 1977;13(1):319-37. PMID: 322750

Recent systematic reviews

The prevalence of the extensor digitorum communis tendon and its insertion variants: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 Nov;27(8):1284-90. Epub 2014 Jun 23 doi: 10.1002/ca.22429. PMID: 24953717

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