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Ectopic lacrimal punctum

MedGen UID:
866875
•Concept ID:
C4021230
•
Anatomical Abnormality
Synonym: Abnormal position of the lacrimal punctum
 
HPO: HP:0010748

Definition

Positioning of a lacrimal punctum other than at the medial margins of the eyelid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic lacrimal punctum

Conditions with this feature

Nasopalpebral lipoma-coloboma syndrome
MedGen UID:
358378
•Concept ID:
C1868660
•
Disease or Syndrome
Nasopalpebral lipoma-coloboma syndrome (NPLCS) is an autosomal dominant condition characterized by upper eyelid and nasopalpebral lipomas, colobomas of upper and lower eyelids, telecanthus, and maxillary hypoplasia (summary by Suresh et al., 2011).
See: Condition Record
Nasopalpebral lipoma-coloboma syndrome

Professional guidelines

PubMed

B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment.
Cornec D, Devauchelle-Pensec V, Tobón GJ, Pers JO, Jousse-Joulin S, Saraux A
J Autoimmun 2012 Sep;39(3):161-7. Epub 2012 Jun 30 doi: 10.1016/j.jaut.2012.05.014. PMID: 22749831

Recent clinical studies

Etiology

Dacryops and clinical diagnostic challenges.
Alsarhani WK, Al-Sharif EM, Al-Faky YH, Alkatan HM, Maktabi AM, Alsuhaibani AH
Can J Ophthalmol 2022 Dec;57(6):388-393. Epub 2021 Jul 26 doi: 10.1016/j.jcjo.2021.06.014. PMID: 34324876
Medial Epicanthoplasty Using a Lower Palpebral Margin Incision Combined With a Tiny Triangular Flap.
Yang F, Zhang J, Gu C, Chen W
Aesthetic Plast Surg 2021 Jun;45(3):1056-1063. Epub 2021 Feb 11 doi: 10.1007/s00266-021-02151-4. PMID: 33575878
Accessory lacrimal gland tumours of the eye region.
Mulay K, Rasmussen PK, Aggarwal E, Honavar SG, Heegaard S
Acta Ophthalmol 2018 Nov;96(7):e772-e775. Epub 2018 May 31 doi: 10.1111/aos.13712. PMID: 29855174
The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis.
Guo J, Qian J, Zhang R
BMC Ophthalmol 2016 May 26;16:66. doi: 10.1186/s12886-016-0250-0. PMID: 27230507Free PMC Article
Cyst of ectopic (choristomatous) lacrimal gland.
Rao VA, Kwatra V, Puri A
Indian J Ophthalmol 1989 Oct-Dec;37(4):189-90. PMID: 2638308

Diagnosis

Complication of Ectopic Lacrimal Gland Tumor on Long-term Follow-up: A Case Report.
Choi JY, Jang YK, Han JC
Korean J Ophthalmol 2023 Aug;37(4):348-349. Epub 2023 Jun 19 doi: 10.3341/kjo.2023.0035. PMID: 37336510Free PMC Article
Large dacryops with an ectopic lacrimal ductule following membranous conjunctivitis.
Singh S, Basu S
Indian J Ophthalmol 2023 May;71(5):2267-2268. doi: 10.4103/IJO.IJO_2624_22. PMID: 37202967Free PMC Article
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Ectopic Lacrimal Gland Underlying a Caruncular Nevus.
Raven ML, Larson JC, Potter HD
Ophthalmology 2016 May;123(5):1136. doi: 10.1016/j.ophtha.2016.02.023. PMID: 27107356
Glial heterotopia or ectopic brain masquerading as a dacyrocystocele.
Ali MJ, Kamal S, Vemuganti GK, Naik MN
Ophthalmic Plast Reconstr Surg 2015 Mar-Apr;31(2):e26-8. doi: 10.1097/IOP.0000000000000050. PMID: 24492734

Therapy

B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment.
Cornec D, Devauchelle-Pensec V, Tobón GJ, Pers JO, Jousse-Joulin S, Saraux A
J Autoimmun 2012 Sep;39(3):161-7. Epub 2012 Jun 30 doi: 10.1016/j.jaut.2012.05.014. PMID: 22749831
Temporary uniocular blindness and ophthalmoplegia associated with a mandibular block injection. A case report.
Wilkie GJ
Aust Dent J 2000 Jun;45(2):131-3. doi: 10.1111/j.1834-7819.2000.tb00253.x. PMID: 10925510
Severe hypertension during anaesthesia for dacryocystorhinostomy.
el-Din AS, Mostafa SM
Anaesthesia 1985 Aug;40(8):787-9. doi: 10.1111/j.1365-2044.1985.tb11007.x. PMID: 4037272
Granulomatous dacryoadenitis caused by Schistosoma haematobium.
Jakobiec FA, Gess L, Zimmerman LE
Arch Ophthalmol 1977 Feb;95(2):278-80. doi: 10.1001/archopht.1977.04450020079013. PMID: 556933

Prognosis

Lacrimal gland choristomas.
Cruz AAV, Limongi RM, Feijó ED, Enz TJ
Arq Bras Oftalmol 2021;85(2):190-199. Epub 2021 Sep 10 doi: 10.5935/0004-2749.20220029. PMID: 35416898
Orbital migration of schistosome eggs: a case report.
Guirou N, Resnikoff S, Yakoura AKH, Gouda M, Bakayoko S, Napo A, Elien RR, Rocca RD, Sylla F, Traoré L
BMC Ophthalmol 2021 Apr 27;21(1):189. doi: 10.1186/s12886-021-01956-w. PMID: 33906611Free PMC Article
A case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure.
Kawakita C, Kinomura M, Gon Y, Okita C, Katayama K, Nishikawa M, Shimada N, Notohara K, Fukushima M, Asano K
CEN Case Rep 2019 Feb;8(1):23-30. Epub 2018 Aug 14 doi: 10.1007/s13730-018-0358-6. PMID: 30109565Free PMC Article
A rare case of atypical pleomorphic adenoma arising from periocular ectopic lacrimal gland.
Wajda BN, Mancini R, Evers B, Nick Hogan R
Int Ophthalmol 2019 Jul;39(7):1617-1619. Epub 2018 Jun 23 doi: 10.1007/s10792-018-0975-2. PMID: 29936687
Complex choristoma of the eyelid containing ectopic cilia and lacrimal gland.
Gordon AJ, Patrinely JR, Knupp JA, Font RL
Ophthalmology 1991 Oct;98(10):1547-50. doi: 10.1016/s0161-6420(91)32090-6. PMID: 1961642

Clinical prediction guides

Dacryops and clinical diagnostic challenges.
Alsarhani WK, Al-Sharif EM, Al-Faky YH, Alkatan HM, Maktabi AM, Alsuhaibani AH
Can J Ophthalmol 2022 Dec;57(6):388-393. Epub 2021 Jul 26 doi: 10.1016/j.jcjo.2021.06.014. PMID: 34324876
Clinical Implications of Goblet Cells in Dacryoadenosis and Normal Human Lacrimal Glands.
Jakobiec FA, Eagle RC Jr, Selig M, Ma L, Shields C
Am J Ophthalmol 2020 May;213:267-282. Epub 2020 Jan 30 doi: 10.1016/j.ajo.2020.01.029. PMID: 32006483
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Accessory lacrimal gland tumours of the eye region.
Mulay K, Rasmussen PK, Aggarwal E, Honavar SG, Heegaard S
Acta Ophthalmol 2018 Nov;96(7):e772-e775. Epub 2018 May 31 doi: 10.1111/aos.13712. PMID: 29855174
The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis.
Guo J, Qian J, Zhang R
BMC Ophthalmol 2016 May 26;16:66. doi: 10.1186/s12886-016-0250-0. PMID: 27230507Free PMC Article

Recent systematic reviews

Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779

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