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Secretory adrenocortical adenoma

MedGen UID:
866774
•Concept ID:
C4021125
•
Neoplastic Process
Synonym: Secretory adrenal adenoma
 
HPO: HP:0011746

Definition

An hormonally active adrenocortical adenoma, that is, an adenoma that secretes excessive amounts of adrenal hormones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecretory adrenocortical adenoma

Recent clinical studies

Etiology

Can MDCT Enhancement Patterns Be Helpful in Differentiating Secretory from Non-Functional Adrenal Adenoma?
Kocic S, Vukomanovic V, Djukic A, Saponjski J, Saponjski D, Aleksic V, Ignjatovic V, Vuleta Nedic K, Markovic V, Vojinovic R
Medicina (Kaunas) 2023 Dec 29;60(1) doi: 10.3390/medicina60010072. PMID: 38256333Free PMC Article
Enhanced performance of a modified diagnostic test of primary aldosteronism in patients with adrenal adenomas.
Markou A, Kaltsas GA, Papanastasiou L, Gravvanis C, Voulgaris N, Kanti G, Zografos GN, Chrousos GP, Piaditis G
Eur J Endocrinol 2022 Jan 6;186(2):265-273. doi: 10.1530/EJE-21-0625. PMID: 34882580
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma.
Hasassri ME, Pandian TK, Bobr AA, Bancos I, Young WF Jr, Richards ML, Farley DR, Thompson GB, McKenzie TJ
World J Surg 2017 Dec;41(12):3147-3153. doi: 10.1007/s00268-017-4110-8. PMID: 28762170
Adrenal incidentalomas: a disease of modern technology offering opportunities for improved patient care.
Ioachimescu AG, Remer EM, Hamrahian AH
Endocrinol Metab Clin North Am 2015 Jun;44(2):335-54. doi: 10.1016/j.ecl.2015.02.005. PMID: 26038204
Mast cell hyperplasia is associated with aldosterone hypersecretion in a subset of aldosterone-producing adenomas.
Duparc C, Moreau L, Dzib JF, Boyer HG, Tetsi Nomigni M, Boutelet I, Boulkroun S, Mukai K, Benecke AG, Amar L, Gobet F, Meatchi T, Plouin PF, Zennaro MC, Louiset E, Lefebvre H
J Clin Endocrinol Metab 2015 Apr;100(4):E550-60. Epub 2015 Jan 19 doi: 10.1210/jc.2014-3660. PMID: 25599386

Diagnosis

Bilateral co-secretory lesions presenting with coexisting Cushing syndrome and primary aldosteronism: a case report.
Gao H, Li L, Chen F, Ren Y, Chen T, Tian H
BMC Endocr Disord 2023 Nov 29;23(1):263. doi: 10.1186/s12902-023-01454-8. PMID: 38017509Free PMC Article
Case series: Primary aldosteronism diagnosed despite normal screening investigations: A report of three cases.
Jia M, Lin L, Yu H, Yang B, Xu X, Song X
Medicine (Baltimore) 2023 May 19;102(20):e33724. doi: 10.1097/MD.0000000000033724. PMID: 37335717Free PMC Article
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma.
Hasassri ME, Pandian TK, Bobr AA, Bancos I, Young WF Jr, Richards ML, Farley DR, Thompson GB, McKenzie TJ
World J Surg 2017 Dec;41(12):3147-3153. doi: 10.1007/s00268-017-4110-8. PMID: 28762170
Adrenal incidentalomas: a disease of modern technology offering opportunities for improved patient care.
Ioachimescu AG, Remer EM, Hamrahian AH
Endocrinol Metab Clin North Am 2015 Jun;44(2):335-54. doi: 10.1016/j.ecl.2015.02.005. PMID: 26038204
Functioning adrenocortical tumors in children-secretory behavior.
Ghazi AA, Mofid D, Salehian MT, Amirbaigloo A, Zare K, Jafari B, Rahimi F
J Clin Res Pediatr Endocrinol 2013;5(1):27-32. Epub 2013 Feb 19 doi: 10.4274/Jcrpe.835. PMID: 23367496Free PMC Article

Therapy

Enhanced performance of a modified diagnostic test of primary aldosteronism in patients with adrenal adenomas.
Markou A, Kaltsas GA, Papanastasiou L, Gravvanis C, Voulgaris N, Kanti G, Zografos GN, Chrousos GP, Piaditis G
Eur J Endocrinol 2022 Jan 6;186(2):265-273. doi: 10.1530/EJE-21-0625. PMID: 34882580
Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma.
Hasassri ME, Pandian TK, Bobr AA, Bancos I, Young WF Jr, Richards ML, Farley DR, Thompson GB, McKenzie TJ
World J Surg 2017 Dec;41(12):3147-3153. doi: 10.1007/s00268-017-4110-8. PMID: 28762170
Robot-assisted adrenalectomy: indications and drawbacks.
Nomine-Criqui C, Germain A, Ayav A, Bresler L, Brunaud L
Updates Surg 2017 Jun;69(2):127-133. Epub 2017 May 12 doi: 10.1007/s13304-017-0448-6. PMID: 28497219
Reversible suppression of the renin-aldosterone axis after unilateral adrenalectomy for adrenal adenoma.
Gadallah MF, Kayyas Y, Boules F
Am J Kidney Dis 1998 Jul;32(1):160-3. doi: 10.1053/ajkd.1998.v32.pm9669438. PMID: 9669438
Effect of the serotonin 5-HT4 receptor agonist cisapride on aldosterone secretion in corticotropic insufficiency and primary hyperaldosteronism.
Lefebvre H, Dhib M, Godin M, Contesse V, Delarue C, Rieu M, Wolf LM, Vaudry H, Kuhn JM
Neuroendocrinology 1997 Sep;66(3):229-33. doi: 10.1159/000127242. PMID: 9380281

Prognosis

The relevance of cortisol co-secretion from aldosterone-producing adenomas.
Bhatt PS, Sam AH, Meeran KM, Salem V
Hormones (Athens) 2019 Sep;18(3):307-313. doi: 10.1007/s42000-019-00114-8. PMID: 31399957Free PMC Article
Ultrastructural findings in adrenal cortical adenomas clinically mimicking pheochromocytoma: a comparison with other adrenal tumors and tissue preparation techniques.
Perrino CM, Prall DN, Calomeni EP, Nadasdy T, Zynger DL
Ultrastruct Pathol 2012 Oct;36(5):287-93. doi: 10.3109/01913123.2012.697980. PMID: 23025647
Pattern of adrenal hormonal secretion in patients with adrenal adenomas: the relevance of aldosterone in arterial hypertension.
Pappa T, Papanastasiou L, Kaltsas G, Markou A, Tsounas P, Androulakis I, Tsiavos V, Zografos G, Vamvakidis K, Samara C, Piaditis G
J Clin Endocrinol Metab 2012 Apr;97(4):E537-45. Epub 2012 Feb 8 doi: 10.1210/jc.2011-2874. PMID: 22319028

Clinical prediction guides

Mast cell hyperplasia is associated with aldosterone hypersecretion in a subset of aldosterone-producing adenomas.
Duparc C, Moreau L, Dzib JF, Boyer HG, Tetsi Nomigni M, Boutelet I, Boulkroun S, Mukai K, Benecke AG, Amar L, Gobet F, Meatchi T, Plouin PF, Zennaro MC, Louiset E, Lefebvre H
J Clin Endocrinol Metab 2015 Apr;100(4):E550-60. Epub 2015 Jan 19 doi: 10.1210/jc.2014-3660. PMID: 25599386
Localization of the endothelin system in aldosterone-producing adenomas.
Egidy G, Baviera E, Ciuffo G, Corvol P, Pinet F
Hypertension 2001 Nov;38(5):1137-42. doi: 10.1161/hy1001.092652. PMID: 11711511
Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies.
Tsagarakis S, Tsigos C, Vassiliou V, Tsiotra P, Pratsinis H, Kletsas D, Trivizas P, Nikou A, Mavromatis T, Sotsiou F, Raptis S, Thalassinos N
J Clin Endocrinol Metab 2001 Feb;86(2):583-9. doi: 10.1210/jcem.86.2.7171. PMID: 11158012
Clonal analysis of human adrenocortical carcinomas and secreting adenomas.
Gicquel C, Leblond-Francillard M, Bertagna X, Louvel A, Chapuis Y, Luton JP, Girard F, Le Bouc Y
Clin Endocrinol (Oxf) 1994 Apr;40(4):465-77. doi: 10.1111/j.1365-2265.1994.tb02485.x. PMID: 7910530
Reduced adrenal secretory mass after unilateral adrenalectomy for aldosterone-producing adenoma may explain unexpected incidence of hypotension.
Gordon RD, Hawkins PG, Hamlet SM, Tunny TJ, Klemm SA, Bachmann AW, Finn WL
J Hypertens Suppl 1989 Dec;7(6):S210-1. doi: 10.1097/00004872-198900076-00101. PMID: 2698927

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