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Calcineurin Nephrotoxicity

MedGen UID:
859325
•Concept ID:
C3899731
•
Disease or Syndrome
Synonym: Calcineurin Inhibitor Nephrotoxicity

Definition

Kidney injury caused by calcineurin inhibitor immunosuppressive therapy which may lead to diminished kidney function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcineurin Nephrotoxicity

Professional guidelines

PubMed

Chronic Allograft Injury: An Overview of Pathogenesis and Treatment Strategies.
Madariaga HM, Riella LV
Contrib Nephrol 2017;190:168-180. Epub 2017 May 23 doi: 10.1159/000468963. PMID: 28535528
Management of renal dysfunction in the liver transplant recipient.
Pham PT, Pham PC, Wilkinson AH
Curr Opin Organ Transplant 2009 Jun;14(3):231-9. doi: 10.1097/MOT.0b013e32832b34a4. PMID: 19395967

Recent clinical studies

Etiology

Chronic Allograft Injury: An Overview of Pathogenesis and Treatment Strategies.
Madariaga HM, Riella LV
Contrib Nephrol 2017;190:168-180. Epub 2017 May 23 doi: 10.1159/000468963. PMID: 28535528
Safety of mTOR inhibitors in adult solid organ transplantation.
Ventura-Aguiar P, Campistol JM, Diekmann F
Expert Opin Drug Saf 2016;15(3):303-19. Epub 2016 Jan 28 doi: 10.1517/14740338.2016.1132698. PMID: 26667069
Alemtuzumab and sirolimus in renal transplantation: six-year results of a single-arm prospective pilot study.
Sutherland AI, Akhtar MZ, Zilvetti M, Brockmann J, Ruse S, Fuggle SV, Sinha S, Harden P, Friend PJ
Am J Transplant 2014 Mar;14(3):677-84. doi: 10.1111/ajt.12572. PMID: 24612687
Chronic progressive calcineurin nephrotoxicity: an overstated concept.
Matas AJ
Am J Transplant 2011 Apr;11(4):687-92. doi: 10.1111/j.1600-6143.2011.03505.x. PMID: 21446973Free PMC Article
The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging.
Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC
Kidney Int 2004 May;65(5):1556-9. doi: 10.1111/j.1523-1755.2004.05410.x. PMID: 15086891

Diagnosis

Approach to Kidney Allograft Dysfunction: A Brief Review.
Haq K, Yadav A, Mejia C
Adv Kidney Dis Health 2024 Sep;31(5):416-426. doi: 10.1053/j.akdh.2024.06.002. PMID: 39232612
Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy.
Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Combined heart and liver transplantation: a single-center experience.
Raichlin E, Daly RC, Rosen CB, McGregor CG, Charlton MR, Frantz RP, Clavell AL, Rodeheffer RJ, Pereira NL, Kremers WK, Kushwaha SS, Edwards BS
Transplantation 2009 Jul 27;88(2):219-25. doi: 10.1097/TP.0b013e3181ac60db. PMID: 19623017
Sodium thiosulfate treatment for calcific uremic arteriolopathy in children and young adults.
Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR
Clin J Am Soc Nephrol 2006 Nov;1(6):1161-6. Epub 2006 Aug 30 doi: 10.2215/CJN.01520506. PMID: 17699342

Therapy

Approach to Kidney Allograft Dysfunction: A Brief Review.
Haq K, Yadav A, Mejia C
Adv Kidney Dis Health 2024 Sep;31(5):416-426. doi: 10.1053/j.akdh.2024.06.002. PMID: 39232612
Safety of mTOR inhibitors in adult solid organ transplantation.
Ventura-Aguiar P, Campistol JM, Diekmann F
Expert Opin Drug Saf 2016;15(3):303-19. Epub 2016 Jan 28 doi: 10.1517/14740338.2016.1132698. PMID: 26667069
Alemtuzumab and sirolimus in renal transplantation: six-year results of a single-arm prospective pilot study.
Sutherland AI, Akhtar MZ, Zilvetti M, Brockmann J, Ruse S, Fuggle SV, Sinha S, Harden P, Friend PJ
Am J Transplant 2014 Mar;14(3):677-84. doi: 10.1111/ajt.12572. PMID: 24612687
Calcineurin nephrotoxicity.
Williams D, Haragsim L
Adv Chronic Kidney Dis 2006 Jan;13(1):47-55. doi: 10.1053/j.ackd.2005.11.001. PMID: 16412970
The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging.
Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC
Kidney Int 2004 May;65(5):1556-9. doi: 10.1111/j.1523-1755.2004.05410.x. PMID: 15086891

Prognosis

Alemtuzumab and sirolimus in renal transplantation: six-year results of a single-arm prospective pilot study.
Sutherland AI, Akhtar MZ, Zilvetti M, Brockmann J, Ruse S, Fuggle SV, Sinha S, Harden P, Friend PJ
Am J Transplant 2014 Mar;14(3):677-84. doi: 10.1111/ajt.12572. PMID: 24612687
Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy.
Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Combined heart and liver transplantation: a single-center experience.
Raichlin E, Daly RC, Rosen CB, McGregor CG, Charlton MR, Frantz RP, Clavell AL, Rodeheffer RJ, Pereira NL, Kremers WK, Kushwaha SS, Edwards BS
Transplantation 2009 Jul 27;88(2):219-25. doi: 10.1097/TP.0b013e3181ac60db. PMID: 19623017
Evolution and pathophysiology of renal-transplant glomerulosclerosis.
Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR
Transplantation 2004 Aug 15;78(3):461-8. doi: 10.1097/01.tp.0000128612.75163.26. PMID: 15316377

Clinical prediction guides

Histological findings of early graft biopsies in old donor renal transplant patients receiving induction therapy.
Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Evolution and pathophysiology of renal-transplant glomerulosclerosis.
Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR
Transplantation 2004 Aug 15;78(3):461-8. doi: 10.1097/01.tp.0000128612.75163.26. PMID: 15316377

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