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Childhood Gliosarcoma

MedGen UID:
859252
•Concept ID:
C3899658
•
Neoplastic Process

Definition

A gliosarcoma that occurs during childhood. [from NCI]

Recent clinical studies

Etiology

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article

Diagnosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Dural-based atypical teratoid/rhabdoid tumor in an adult: DNA methylation profiling as a tool for the diagnosis.
Alzoubi H, Gianno F, Giangaspero F, Bartolini D, Riccioni L, Miele E, Antonelli M
CNS Oncol 2020 Jun;9(2):CNS54. Epub 2020 Jun 30 doi: 10.2217/cns-2020-0006. PMID: 32602741Free PMC Article
Giant infantile gliosarcoma: magnetic resonance imaging findings.
Sanal HT, Bulakbasi N, Kocaoglu M, Onguru O, Chen L
J Child Neurol 2008 Aug;23(8):926-9. Epub 2008 Apr 10 doi: 10.1177/0883073808314897. PMID: 18403585
Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic astrocytoma in childhood.
Jager B, Schuhmann MU, Schober R, Kortmann RD, Meixensberger J
Pediatr Neurosurg 2008;44(2):153-8. Epub 2008 Jan 24 doi: 10.1159/000113120. PMID: 18230932
Childhood's gliosarcomas: pathological and therapeutical considerations on three cases and critical review of the literature.
Salvati M, Lenzi J, Brogna C, Frati A, Piccirilli M, Giangaspero F, Raco A
Childs Nerv Syst 2006 Oct;22(10):1301-6. Epub 2006 Mar 16 doi: 10.1007/s000381-006-0057-z. PMID: 16541294

Therapy

Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic astrocytoma in childhood.
Jager B, Schuhmann MU, Schober R, Kortmann RD, Meixensberger J
Pediatr Neurosurg 2008;44(2):153-8. Epub 2008 Jan 24 doi: 10.1159/000113120. PMID: 18230932

Prognosis

Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE
Acta Neuropathol 2022 Feb;143(2):263-281. Epub 2021 Dec 30 doi: 10.1007/s00401-021-02395-z. PMID: 34967922Free PMC Article
Induction of gliosarcoma and atypical meningioma 13 years after radiotherapy of residual pilocytic astrocytoma in childhood.
Jager B, Schuhmann MU, Schober R, Kortmann RD, Meixensberger J
Pediatr Neurosurg 2008;44(2):153-8. Epub 2008 Jan 24 doi: 10.1159/000113120. PMID: 18230932
Giant cell glioblastoma multiforme: report of a case with prolonged survival and transformation to gliosarcoma.
Deb P, Sharma MC, Chander B, Mahapatra AK, Sarkar C
Childs Nerv Syst 2006 Mar;22(3):314-9. Epub 2005 Aug 16 doi: 10.1007/s00381-005-1239-9. PMID: 16133270

Clinical prediction guides

Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system.
Del Valle L, Gordon J, Assimakopoulou M, Enam S, Geddes JF, Varakis JN, Katsetos CD, Croul S, Khalili K
Cancer Res 2001 May 15;61(10):4287-93. PMID: 11358858

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