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Childhood Lung Non-Small Cell Carcinoma

MedGen UID:
859244
•Concept ID:
C3899650
•
Neoplastic Process
Synonyms: Childhood Non-Small Cell Lung Cancer; Childhood Non-Small Cell Lung Carcinoma

Definition

A rare non-small cell carcinoma of the lung that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Lung Non-Small Cell Carcinoma

Professional guidelines

PubMed

Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT).
Abele M, Bajčiová V, Wright F, Behjati S, Voggel S, Schneider DT, Mallebranche C, Česen Mazič M, Guillén G, Krawczyk M, Bień E, Roganovic J, Bisogno G, Chiaravalli S, Ferrari A, Brecht IB, Orbach D, Reguerre Y, Virgone C
Eur J Cancer 2022 Nov;175:19-30. Epub 2022 Sep 7 doi: 10.1016/j.ejca.2022.08.007. PMID: 36087394

Recent clinical studies

Etiology

Predictors of thyroid adverse events during cancer immunotherapy: a real-life experience at a single center.
Ruggeri RM, Spagnolo CC, Alibrandi A, Silvestris N, Cannavò S, Santarpia M
J Endocrinol Invest 2023 Nov;46(11):2399-2409. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02096-2. PMID: 37076759
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
Goldsmith KC, Park JR, Kayser K, Malvar J, Chi YY, Groshen SG, Villablanca JG, Krytska K, Lai LM, Acharya PT, Goodarzian F, Pawel B, Shimada H, Ghazarian S, States L, Marshall L, Chesler L, Granger M, Desai AV, Mody R, Morgenstern DA, Shusterman S, Macy ME, Pinto N, Schleiermacher G, Vo K, Thurm HC, Chen J, Liyanage M, Peltz G, Matthay KK, Berko ER, Maris JM, Marachelian A, Mossé YP
Nat Med 2023 May;29(5):1092-1102. Epub 2023 Apr 3 doi: 10.1038/s41591-023-02297-5. PMID: 37012551Free PMC Article
Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT).
Abele M, Bajčiová V, Wright F, Behjati S, Voggel S, Schneider DT, Mallebranche C, Česen Mazič M, Guillén G, Krawczyk M, Bień E, Roganovic J, Bisogno G, Chiaravalli S, Ferrari A, Brecht IB, Orbach D, Reguerre Y, Virgone C
Eur J Cancer 2022 Nov;175:19-30. Epub 2022 Sep 7 doi: 10.1016/j.ejca.2022.08.007. PMID: 36087394
Chronic obstructive lung diseases and risk of non-small cell lung cancer in women.
Schwartz AG, Cote ML, Wenzlaff AS, Van Dyke A, Chen W, Ruckdeschel JC, Gadgeel S, Soubani AO
J Thorac Oncol 2009 Mar;4(3):291-9. doi: 10.1097/JTO.0b013e3181951cd1. PMID: 19190518Free PMC Article
Paranuclear blue inclusions in small cell undifferentiated carcinoma: a diagnostically useful finding demonstrated in fine-needle aspiration biopsy smears.
Walker WP, Wittchow RJ, Bottles K, Layfield LJ, Hirschowitz S, Cohen MB
Diagn Cytopathol 1994;10(3):212-5. doi: 10.1002/dc.2840100304. PMID: 8050327

Diagnosis

Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
Goldsmith KC, Park JR, Kayser K, Malvar J, Chi YY, Groshen SG, Villablanca JG, Krytska K, Lai LM, Acharya PT, Goodarzian F, Pawel B, Shimada H, Ghazarian S, States L, Marshall L, Chesler L, Granger M, Desai AV, Mody R, Morgenstern DA, Shusterman S, Macy ME, Pinto N, Schleiermacher G, Vo K, Thurm HC, Chen J, Liyanage M, Peltz G, Matthay KK, Berko ER, Maris JM, Marachelian A, Mossé YP
Nat Med 2023 May;29(5):1092-1102. Epub 2023 Apr 3 doi: 10.1038/s41591-023-02297-5. PMID: 37012551Free PMC Article
Evaluation of the DLL3-targeting antibody-drug conjugate rovalpituzumab tesirine in preclinical models of neuroblastoma.
Krytska K, Casey CE, Pogoriler J, Martinez D, Rathi KS, Farrel A, Berko ER, Tsang M, Sano RR, Kendsersky N, Erickson SW, Teicher BA, Isse K, Saunders L, Smith MA, Maris JM, Mossé YP
Cancer Res Commun 2022 Jul;2(7):616-623. Epub 2022 Jul 11 doi: 10.1158/2767-9764.crc-22-0137. PMID: 36381237Free PMC Article
Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT).
Abele M, Bajčiová V, Wright F, Behjati S, Voggel S, Schneider DT, Mallebranche C, Česen Mazič M, Guillén G, Krawczyk M, Bień E, Roganovic J, Bisogno G, Chiaravalli S, Ferrari A, Brecht IB, Orbach D, Reguerre Y, Virgone C
Eur J Cancer 2022 Nov;175:19-30. Epub 2022 Sep 7 doi: 10.1016/j.ejca.2022.08.007. PMID: 36087394
Chronic obstructive lung diseases and risk of non-small cell lung cancer in women.
Schwartz AG, Cote ML, Wenzlaff AS, Van Dyke A, Chen W, Ruckdeschel JC, Gadgeel S, Soubani AO
J Thorac Oncol 2009 Mar;4(3):291-9. doi: 10.1097/JTO.0b013e3181951cd1. PMID: 19190518Free PMC Article
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.
Pettersson HM, Pietras A, Munksgaard Persson M, Karlsson J, Johansson L, Shoshan MC, Påhlman S
Mol Cancer Ther 2009 Jan;8(1):160-70. doi: 10.1158/1535-7163.MCT-08-0595. PMID: 19139125

Therapy

Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study.
Wu D, Zhou J, Huang Y, Zheng Q, Wang T, Liu L
Cancer Med 2023 Sep;12(17):18418-18424. Epub 2023 Aug 7 doi: 10.1002/cam4.6406. PMID: 37548289Free PMC Article
Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.
Berko ER, Witek GM, Matkar S, Petrova ZO, Wu MA, Smith CM, Daniels A, Kalna J, Kennedy A, Gostuski I, Casey C, Krytska K, Gerelus M, Pavlick D, Ghazarian S, Park JR, Marachelian A, Maris JM, Goldsmith KC, Radhakrishnan R, Lemmon MA, Mossé YP
Nat Commun 2023 May 5;14(1):2601. doi: 10.1038/s41467-023-38195-0. PMID: 37147298Free PMC Article
Addressing resistance to PD-1/PD-(L)1 pathway inhibition: considerations for combinatorial clinical trial designs.
Zhang T, Forde PM, Sullivan RJ, Sharon E, Barksdale E, Selig W, Ebbinghaus S, Fusaro G, Gunenc D, Battle D, Burns R, Hurlbert MS, Stewart M, Atkins MB
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006555. PMID: 37137552Free PMC Article
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results.
Goldsmith KC, Park JR, Kayser K, Malvar J, Chi YY, Groshen SG, Villablanca JG, Krytska K, Lai LM, Acharya PT, Goodarzian F, Pawel B, Shimada H, Ghazarian S, States L, Marshall L, Chesler L, Granger M, Desai AV, Mody R, Morgenstern DA, Shusterman S, Macy ME, Pinto N, Schleiermacher G, Vo K, Thurm HC, Chen J, Liyanage M, Peltz G, Matthay KK, Berko ER, Maris JM, Marachelian A, Mossé YP
Nat Med 2023 May;29(5):1092-1102. Epub 2023 Apr 3 doi: 10.1038/s41591-023-02297-5. PMID: 37012551Free PMC Article
Evaluation of the DLL3-targeting antibody-drug conjugate rovalpituzumab tesirine in preclinical models of neuroblastoma.
Krytska K, Casey CE, Pogoriler J, Martinez D, Rathi KS, Farrel A, Berko ER, Tsang M, Sano RR, Kendsersky N, Erickson SW, Teicher BA, Isse K, Saunders L, Smith MA, Maris JM, Mossé YP
Cancer Res Commun 2022 Jul;2(7):616-623. Epub 2022 Jul 11 doi: 10.1158/2767-9764.crc-22-0137. PMID: 36381237Free PMC Article

Prognosis

Differential predictive value of resident memory CD8(+)T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy.
Paolini L, Tran T, Corgnac S, Villemin JP, Wislez M, Arrondeau J, Johannes L, Ulmer J, Vieillard LV, Pineau J, Gey A, Quiniou V, Barennes P, Pham HP, Gruel N, Hasan M, Libri V, Mella S, De Percin S, Boudou-Rouquette P, Caidi A, Cremer I, Blons H, Leroy K, Laurent-Puig P, De Saint Basile H, Gibault L, Ravel P, Mami-Chouaib F, Goldwasser F, Fabre E, Damotte D, Tartour E
J Immunother Cancer 2024 Dec 3;12(12) doi: 10.1136/jitc-2024-009440. PMID: 39631852Free PMC Article
Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study.
Wu D, Zhou J, Huang Y, Zheng Q, Wang T, Liu L
Cancer Med 2023 Sep;12(17):18418-18424. Epub 2023 Aug 7 doi: 10.1002/cam4.6406. PMID: 37548289Free PMC Article
Predictors of thyroid adverse events during cancer immunotherapy: a real-life experience at a single center.
Ruggeri RM, Spagnolo CC, Alibrandi A, Silvestris N, Cannavò S, Santarpia M
J Endocrinol Invest 2023 Nov;46(11):2399-2409. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02096-2. PMID: 37076759
Primary lung carcinoma in children and adolescents: An analysis of the European Cooperative Study Group on Paediatric Rare Tumours (EXPeRT).
Abele M, Bajčiová V, Wright F, Behjati S, Voggel S, Schneider DT, Mallebranche C, Česen Mazič M, Guillén G, Krawczyk M, Bień E, Roganovic J, Bisogno G, Chiaravalli S, Ferrari A, Brecht IB, Orbach D, Reguerre Y, Virgone C
Eur J Cancer 2022 Nov;175:19-30. Epub 2022 Sep 7 doi: 10.1016/j.ejca.2022.08.007. PMID: 36087394
Chronic obstructive lung diseases and risk of non-small cell lung cancer in women.
Schwartz AG, Cote ML, Wenzlaff AS, Van Dyke A, Chen W, Ruckdeschel JC, Gadgeel S, Soubani AO
J Thorac Oncol 2009 Mar;4(3):291-9. doi: 10.1097/JTO.0b013e3181951cd1. PMID: 19190518Free PMC Article

Clinical prediction guides

Differential predictive value of resident memory CD8(+)T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy.
Paolini L, Tran T, Corgnac S, Villemin JP, Wislez M, Arrondeau J, Johannes L, Ulmer J, Vieillard LV, Pineau J, Gey A, Quiniou V, Barennes P, Pham HP, Gruel N, Hasan M, Libri V, Mella S, De Percin S, Boudou-Rouquette P, Caidi A, Cremer I, Blons H, Leroy K, Laurent-Puig P, De Saint Basile H, Gibault L, Ravel P, Mami-Chouaib F, Goldwasser F, Fabre E, Damotte D, Tartour E
J Immunother Cancer 2024 Dec 3;12(12) doi: 10.1136/jitc-2024-009440. PMID: 39631852Free PMC Article
Anaplastic Lymphoma Kinase Inhibitors for Therapy of Neuroblastoma in Adults.
Stiefel J, Kushner BH, Roberts SS, Iglesias-Cardenas F, Kramer K, Modak S
JCO Precis Oncol 2023 Aug;7:e2300138. doi: 10.1200/PO.23.00138. PMID: 37561984Free PMC Article
Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study.
Wu D, Zhou J, Huang Y, Zheng Q, Wang T, Liu L
Cancer Med 2023 Sep;12(17):18418-18424. Epub 2023 Aug 7 doi: 10.1002/cam4.6406. PMID: 37548289Free PMC Article
Predictors of thyroid adverse events during cancer immunotherapy: a real-life experience at a single center.
Ruggeri RM, Spagnolo CC, Alibrandi A, Silvestris N, Cannavò S, Santarpia M
J Endocrinol Invest 2023 Nov;46(11):2399-2409. Epub 2023 Apr 20 doi: 10.1007/s40618-023-02096-2. PMID: 37076759
Evaluation of the DLL3-targeting antibody-drug conjugate rovalpituzumab tesirine in preclinical models of neuroblastoma.
Krytska K, Casey CE, Pogoriler J, Martinez D, Rathi KS, Farrel A, Berko ER, Tsang M, Sano RR, Kendsersky N, Erickson SW, Teicher BA, Isse K, Saunders L, Smith MA, Maris JM, Mossé YP
Cancer Res Commun 2022 Jul;2(7):616-623. Epub 2022 Jul 11 doi: 10.1158/2767-9764.crc-22-0137. PMID: 36381237Free PMC Article

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