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Idiopathic Tall Stature

MedGen UID:
858407
•Concept ID:
C3898813
•
Finding

Definition

Tall stature for which no underlying cause can be found. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic Tall Stature

Professional guidelines

PubMed

Towards a Rational and Efficient Diagnostic Approach in Children Referred for Tall Stature and/or Accelerated Growth to the General Paediatrician.
Lauffer P, Kamp GA, Menke LA, Wit JM, Oostdijk W; on behalf of the Dutch Working Group on Triage and Diagnosis of Growth Disorders in Children
Horm Res Paediatr 2019;91(5):293-310. Epub 2019 Jul 12 doi: 10.1159/000500810. PMID: 31302655
Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice.
Stalman SE, Pons A, Wit JM, Kamp GA, Plötz FB
J Clin Res Pediatr Endocrinol 2015 Dec;7(4):260-7. doi: 10.4274/jcrpe.2220. PMID: 26777036Free PMC Article

Recent clinical studies

Etiology

Short stature homeobox-containing gene duplications in 3.7% of girls with tall stature and normal karyotypes.
Upners EN, Jensen RB, Rajpert-De Meyts E, Dunø M, Aksglaede L, Juul A
Acta Paediatr 2017 Oct;106(10):1651-1657. Epub 2017 Jul 20 doi: 10.1111/apa.13969. PMID: 28667773
24-hour secretion of growth hormone (GH), insulin-like growth factors-I and -II (IGF-I, -II), prolactin (PRL) and thyrotropin (TSH) in young adults of normal and tall stature.
Stratakis CA, Mastorakos G, Magiakou MA, Papavasiliou EC, Panitsa-Faflia C, Georgiadis E, Batrinos ML
Endocr Res 1996 Aug;22(3):261-76. doi: 10.3109/07435809609030511. PMID: 8875138

Diagnosis

Short stature homeobox-containing gene duplications in 3.7% of girls with tall stature and normal karyotypes.
Upners EN, Jensen RB, Rajpert-De Meyts E, Dunø M, Aksglaede L, Juul A
Acta Paediatr 2017 Oct;106(10):1651-1657. Epub 2017 Jul 20 doi: 10.1111/apa.13969. PMID: 28667773

Clinical prediction guides

Short stature homeobox-containing gene duplications in 3.7% of girls with tall stature and normal karyotypes.
Upners EN, Jensen RB, Rajpert-De Meyts E, Dunø M, Aksglaede L, Juul A
Acta Paediatr 2017 Oct;106(10):1651-1657. Epub 2017 Jul 20 doi: 10.1111/apa.13969. PMID: 28667773

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