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Isolated Premature Menarche

MedGen UID:
858256
•Concept ID:
C3898662
•
Disease or Syndrome

Definition

Occurrence of the first menstrual period in a girl before the lower limit of the normal age range for the reference population, without other signs of puberty. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsolated Premature Menarche

Professional guidelines

PubMed

Update on the etiology, diagnosis and therapeutic management of sexual precocity.
Brito VN, Latronico AC, Arnhold IJ, Mendonça BB
Arq Bras Endocrinol Metabol 2008 Feb;52(1):18-31. doi: 10.1590/s0004-27302008000100005. PMID: 18345393
Polycystic ovary syndrome in adolescents: current and future treatment options.
Mastorakos G, Lambrinoudaki I, Creatsas G
Paediatr Drugs 2006;8(5):311-8. doi: 10.2165/00148581-200608050-00004. PMID: 17037948

Recent clinical studies

Etiology

Vaginal Bleeding in Pre-pubertal Females.
Ng SM, Apperley LJ, Upradrasta S, Natarajan A
J Pediatr Adolesc Gynecol 2020 Aug;33(4):339-342. Epub 2020 Feb 6 doi: 10.1016/j.jpag.2020.01.152. PMID: 32035994
Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study.
Ejaz S, Lane A, Wilson T
Horm Res Paediatr 2015;84(4):217-22. Epub 2015 Jul 8 doi: 10.1159/000435882. PMID: 26160535
Long-term intravaginal presence of foreign bodies in children. A preliminary study.
Pokorny SF
J Reprod Med 1994 Dec;39(12):931-5. PMID: 7884746

Diagnosis

Isolated premature menarche in two siblings with Neurofibromatosis type 1.
Blackburn J, Didi M, Avula S, Senniappan S
J Pediatr Endocrinol Metab 2020 May 21;33(6):813-816. doi: 10.1515/jpem-2019-0494. PMID: 32436861
Vaginal Bleeding in Pre-pubertal Females.
Ng SM, Apperley LJ, Upradrasta S, Natarajan A
J Pediatr Adolesc Gynecol 2020 Aug;33(4):339-342. Epub 2020 Feb 6 doi: 10.1016/j.jpag.2020.01.152. PMID: 32035994
Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study.
Ejaz S, Lane A, Wilson T
Horm Res Paediatr 2015;84(4):217-22. Epub 2015 Jul 8 doi: 10.1159/000435882. PMID: 26160535
Long-term intravaginal presence of foreign bodies in children. A preliminary study.
Pokorny SF
J Reprod Med 1994 Dec;39(12):931-5. PMID: 7884746

Prognosis

Outcome of Isolated Premature Menarche: A Retrospective and Follow-Up Study.
Ejaz S, Lane A, Wilson T
Horm Res Paediatr 2015;84(4):217-22. Epub 2015 Jul 8 doi: 10.1159/000435882. PMID: 26160535

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