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Childhood Pre-B Acute Lymphoblastic Leukemia

MedGen UID:
856554
•Concept ID:
C3896960
•
Disease or Syndrome

Definition

Pre-B acute lymphoblastic leukemia that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Pre-B Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia.
Healy J, Bourgey M, Richer C, Sinnett D, Roy-Gagnon MH
J Biomed Biotechnol 2010;2010:369534. Epub 2010 Jun 9 doi: 10.1155/2010/369534. PMID: 20617153Free PMC Article

Recent clinical studies

Etiology

Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706
5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype.
Castro FV, McGinn OJ, Krishnan S, Marinov G, Li J, Rutkowski AJ, Elkord E, Burt DJ, Holland M, Vaghjiani R, Gallego A, Saha V, Stern PL
Leukemia 2012 Jul;26(7):1487-98. Epub 2012 Jan 23 doi: 10.1038/leu.2012.18. PMID: 22266911Free PMC Article
Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia.
Healy J, Bourgey M, Richer C, Sinnett D, Roy-Gagnon MH
J Biomed Biotechnol 2010;2010:369534. Epub 2010 Jun 9 doi: 10.1155/2010/369534. PMID: 20617153Free PMC Article
Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia.
Healy J, Bélanger H, Beaulieu P, Larivière M, Labuda D, Sinnett D
Blood 2007 Jan 15;109(2):683-92. Epub 2006 Sep 28 doi: 10.1182/blood-2006-02-003236. PMID: 17008550

Diagnosis

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells.
Spinella JF, Cassart P, Garnier N, Rousseau P, Drullion C, Richer C, Ouimet M, Saillour V, Healy J, Autexier C, Sinnett D
BMC Cancer 2015 Sep 7;15:621. doi: 10.1186/s12885-015-1639-5. PMID: 26345285Free PMC Article
Childhood Pre-B acute lymphoblastic leukemia and glutathione S-transferase omega 1 and 2 polymorphisms.
Rezazadeh D, Moradi MT, Kazemi A, Mansouri K
Int J Lab Hematol 2015 Aug;37(4):530-5. Epub 2015 Feb 27 doi: 10.1111/ijlh.12332. PMID: 25726706
5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype.
Castro FV, McGinn OJ, Krishnan S, Marinov G, Li J, Rutkowski AJ, Elkord E, Burt DJ, Holland M, Vaghjiani R, Gallego A, Saha V, Stern PL
Leukemia 2012 Jul;26(7):1487-98. Epub 2012 Jan 23 doi: 10.1038/leu.2012.18. PMID: 22266911Free PMC Article
Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.
Hansson F, Toporski J, Månsson R, Johansson B, Norén-Nyström U, Jacobsen SE, Wiebe T, Larsson M, Sigvardsson M, Castor A
Mol Cancer 2008 Aug 11;7:67. doi: 10.1186/1476-4598-7-67. PMID: 18694513Free PMC Article
Establishment and characterization of a childhood pre-B acute lymphoblastic leukemia cell line, PER-278, with chromosome translocations t(1;19) and t(1;9).
Kees UR, Lukeis R, Ford J, Willoughby ML, Garson OM
Cancer Genet Cytogenet 1990 Jun;46(2):201-8. doi: 10.1016/0165-4608(90)90105-j. PMID: 2340491

Therapy

The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.
Casagrande G, te Kronnie G, Basso G
Haematologica 2006 Jun;91(6):765-71. PMID: 16769578
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD
Blood 1998 Oct 15;92(8):2879-85. PMID: 9763573
Molecular variants of the 1;19 chromosomal translocation in pediatric acute lymphoblastic leukemia (ALL).
Privitera E, Luciano A, Ronchetti D, Aricò M, Santostasi T, Basso G, Biondi A
Leukemia 1994 Apr;8(4):554-9. PMID: 8152250

Prognosis

5T4 oncofetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype.
Castro FV, McGinn OJ, Krishnan S, Marinov G, Li J, Rutkowski AJ, Elkord E, Burt DJ, Holland M, Vaghjiani R, Gallego A, Saha V, Stern PL
Leukemia 2012 Jul;26(7):1487-98. Epub 2012 Jan 23 doi: 10.1038/leu.2012.18. PMID: 22266911Free PMC Article

Clinical prediction guides

The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line.
Casagrande G, te Kronnie G, Basso G
Haematologica 2006 Jun;91(6):765-71. PMID: 16769578
Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia.
Yotnda P, Garcia F, Peuchmaur M, Grandchamp B, Duval M, Lemonnier F, Vilmer E, Langlade-Demoyen P
J Clin Invest 1998 Jul 15;102(2):455-62. doi: 10.1172/JCI3126. PMID: 9664088Free PMC Article

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