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Kidney Small Cell Neuroendocrine Carcinoma

MedGen UID:
853695
•Concept ID:
C2212425
•
Neoplastic Process
Synonyms: Kidney Small Cell Carcinoma; Renal Small Cell Carcinoma

Definition

A very rare small cell neuroendocrine carcinoma that arises from the kidney. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management.
Shyam Sunder S, Sharma UC, Pokharel S
Signal Transduct Target Ther 2023 Jul 7;8(1):262. doi: 10.1038/s41392-023-01469-6. PMID: 37414756Free PMC Article
Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197

Recent clinical studies

Etiology

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Lymph Node Dissection for Small Renal Masses.
Blute ML Jr, Gupta M, Crispen PL
Urol Clin North Am 2017 May;44(2):269-274. Epub 2017 Mar 14 doi: 10.1016/j.ucl.2016.12.012. PMID: 28411918
The role of biopsy for small renal masses.
Leão RR, Richard PO, Jewett MA
Int J Surg 2016 Dec;36(Pt C):513-517. Epub 2016 Mar 5 doi: 10.1016/j.ijsu.2016.02.097. PMID: 26957016
Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
The evolving management of small renal masses.
Boorjian SA, Uzzo RG
Curr Oncol Rep 2009 May;11(3):211-7. doi: 10.1007/s11912-009-0030-6. PMID: 19336013Free PMC Article

Diagnosis

Combined renal small cell carcinoma: an extremely rare and unexpected case.
Chrabańska M, Ryszawy J, Drozdzowska B
Pol Arch Intern Med 2023 Jan 29;134(1) Epub 2023 Oct 24 doi: 10.20452/pamw.16590. PMID: 37874247
Surgical Management of Localized Disease and Small Renal Masses.
Carson DS, Weiss T, Zhang LX, Psutka SP
Hematol Oncol Clin North Am 2023 Oct;37(5):877-892. Epub 2023 Jun 15 doi: 10.1016/j.hoc.2023.05.003. PMID: 37330345
Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Percutaneous Renal Ablation.
Gupta A, Musaddaq B, von Stempel C, Ilyas S
Semin Ultrasound CT MR 2020 Aug;41(4):351-356. Epub 2020 May 17 doi: 10.1053/j.sult.2020.05.004. PMID: 32620225
Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197

Therapy

LITESPARK-011: belzutifan plus lenvatinib vs cabozantinib in advanced renal cell carcinoma after anti-PD-1/PD-L1 therapy.
Motzer RJ, Schmidinger M, Eto M, Suarez C, Figlin R, Liu Y, Perini R, Zhang Y, Heng DY
Future Oncol 2023 Jan;19(2):113-121. Epub 2023 Feb 8 doi: 10.2217/fon-2022-0802. PMID: 36752726
Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma.
Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Belzutifan: First Approval.
Deeks ED
Drugs 2021 Nov;81(16):1921-1927. doi: 10.1007/s40265-021-01606-x. PMID: 34613603
Emerging surgical treatments for renal cell carcinoma.
Husain FZ, Badani KK, Sfakianos JP, Mehrazin R
Future Oncol 2016 Apr;12(7):921-9. Epub 2016 Feb 19 doi: 10.2217/fon.15.362. PMID: 26892144
Chemotherapy for metastatic bladder cancer.
Roberts JT
Clin Oncol (R Coll Radiol) 2005 Oct;17(7):514-23. doi: 10.1016/j.clon.2005.07.007. PMID: 16238139

Prognosis

Surgical Management of Localized Disease and Small Renal Masses.
Carson DS, Weiss T, Zhang LX, Psutka SP
Hematol Oncol Clin North Am 2023 Oct;37(5):877-892. Epub 2023 Jun 15 doi: 10.1016/j.hoc.2023.05.003. PMID: 37330345
Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer.
Derosa L, Hellmann MD, Spaziano M, Halpenny D, Fidelle M, Rizvi H, Long N, Plodkowski AJ, Arbour KC, Chaft JE, Rouche JA, Zitvogel L, Zalcman G, Albiges L, Escudier B, Routy B
Ann Oncol 2018 Jun 1;29(6):1437-1444. doi: 10.1093/annonc/mdy103. PMID: 29617710Free PMC Article
Renal cell carcinoma.
Cairns P
Cancer Biomark 2010;9(1-6):461-73. doi: 10.3233/CBM-2011-0176. PMID: 22112490Free PMC Article
The evolving management of small renal masses.
Boorjian SA, Uzzo RG
Curr Oncol Rep 2009 May;11(3):211-7. doi: 10.1007/s11912-009-0030-6. PMID: 19336013Free PMC Article
Pathology and staging of urothelial tumors of the kidney and ureter.
Melamed MR, Reuter VE
Urol Clin North Am 1993 May;20(2):333-47. PMID: 8388136

Clinical prediction guides

Renal Cell Carcinoma and Kidney Transplantation: A Narrative Review.
Dahle DO, Skauby M, Langberg CW, Brabrand K, Wessel N, Midtvedt K
Transplantation 2022 Jan 1;106(1):e52-e63. doi: 10.1097/TP.0000000000003762. PMID: 33741842Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Managing Complications Following Nephron-Sparing Procedures for Renal Masses.
Gonzalez-Aguirre AJ, Durack JC
Tech Vasc Interv Radiol 2016 Sep;19(3):194-202. Epub 2016 Jun 3 doi: 10.1053/j.tvir.2016.06.004. PMID: 27641453
Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST.
Nishino M, Jagannathan JP, Krajewski KM, O'Regan K, Hatabu H, Shapiro G, Ramaiya NH
AJR Am J Roentgenol 2012 Apr;198(4):737-45. doi: 10.2214/AJR.11.7483. PMID: 22451534Free PMC Article
Small renal masses: risk prediction and contemporary management.
Yamaguchi Y, Simmons MN, Campbell SC
Hematol Oncol Clin North Am 2011 Aug;25(4):717-36. doi: 10.1016/j.hoc.2011.04.007. PMID: 21763964

Recent systematic reviews

Nephron-sparing surgery for renal cell carcinoma in children and young adults: A systematic review.
Khondker A, Kwong JCC, Chua ME, Kim JK, Chan JYH, Zappitelli M, Brzezinski J, Cost NG, Rickard M, Lorenzo AJ
Urol Oncol 2023 Mar;41(3):137-144. Epub 2022 Nov 22 doi: 10.1016/j.urolonc.2022.09.015. PMID: 36428167
Imaging in Suspected Renal-Cell Carcinoma: Systematic Review.
Vogel C, Ziegelmüller B, Ljungberg B, Bensalah K, Bex A, Canfield S, Giles RH, Hora M, Kuczyk MA, Merseburger AS, Powles T, Albiges L, Stewart F, Volpe A, Graser A, Schlemmer M, Yuan C, Lam T, Staehler M
Clin Genitourin Cancer 2019 Apr;17(2):e345-e355. Epub 2018 Aug 11 doi: 10.1016/j.clgc.2018.07.024. PMID: 30528378
Renal Cell Carcinoma: Alternative Nephron-Sparing Treatment Options for Small Renal Masses, a Systematic Review.
Prins FM, Kerkmeijer LGW, Pronk AA, Vonken EPA, Meijer RP, Bex A, Barendrecht MM
J Endourol 2017 Oct;31(10):963-975. Epub 2017 Aug 22 doi: 10.1089/end.2017.0382. PMID: 28741377
Renal medullary carcinoma and sickle cell trait: A systematic review.
Alvarez O, Rodriguez MM, Jordan L, Sarnaik S
Pediatr Blood Cancer 2015 Oct;62(10):1694-9. Epub 2015 Jun 5 doi: 10.1002/pbc.25592. PMID: 26053587
Focal therapy for kidney cancer: a systematic review.
Kutikov A, Kunkle DA, Uzzo RG
Curr Opin Urol 2009 Mar;19(2):148-53. doi: 10.1097/MOU.0b013e328323f7d7. PMID: 19188769Free PMC Article

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