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Idiopathic Precocious Puberty

MedGen UID:
853627
•Concept ID:
C2113596
•
Disease or Syndrome

Definition

Precocious puberty for which no underlying cause can be identified. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic Precocious Puberty

Professional guidelines

PubMed

Treatment with Depot Leuprolide Acetate in Girls with Idiopathic Precocious Puberty: What Parameter should be Used in Deciding on the Initial Dose?
Vurallı D, Alikaşifoğlu A, İyigün İ, Canoruç D, Ozon A, Gönç N, Kandemir N
J Clin Res Pediatr Endocrinol 2020 Mar 19;12(1):37-44. Epub 2019 Jul 26 doi: 10.4274/jcrpe.galenos.2019.2019.0060. PMID: 31347350Free PMC Article
Treatment of idiopathic precocious puberty.
MacGillivray MH
N Engl J Med 1982 May 6;306(18):1109-10. doi: 10.1056/NEJM198205063061814. PMID: 7040953
Treatment of idiopathic precocious puberty with cyproterone acetate. Proceedings of a discussion, Berlin, April 29, 1977.
Horm Res 1978;9(5):301-12. doi: 10.1159/000178925. PMID: 210100

Recent clinical studies

Etiology

Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Neonatal encephalopathy: an indicator of early sexual maturation in girls.
Robertson CM, Morrish DW, Wheler GH, Grace MG
Pediatr Neurol 1990 Mar-Apr;6(2):102-8. doi: 10.1016/0887-8994(90)90042-y. PMID: 2340026
Idiopathic precocious puberty in girls: psychiatric follow-up in adolescence.
Ehrhardt AA, Meyer-Bahlburg HF, Bell JJ, Cohen SF, Healey JM, Stiel R, Feldman JF, Morishima A, New MI
J Am Acad Child Psychiatry 1984 Jan;23(1):23-33. doi: 10.1097/00004583-198401000-00004. PMID: 6693676
Height predictions in girls with idiopathic precocious puberty by the Bayley-Pinneau method.
Kirkland JL, Gibbs AR, Kirkland RT, Clayton GW
Pediatrics 1981 Aug;68(2):251-2. PMID: 7267233

Diagnosis

11-year old boy with facial hair, acne and deepened voice.
Ahmed F, Zeve D, Millington K, Rea C
BMJ Case Rep 2019 Mar 20;12(3) doi: 10.1136/bcr-2018-226600. PMID: 30898952Free PMC Article
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
True idiopathic precocious puberty presenting at six months of age; a case report.
Nienaber CS, van der Walt D
Eur J Obstet Gynecol Reprod Biol 1991 Feb 25;38(3):243-5. doi: 10.1016/0028-2243(91)90300-a. PMID: 2007453
Neonatal encephalopathy: an indicator of early sexual maturation in girls.
Robertson CM, Morrish DW, Wheler GH, Grace MG
Pediatr Neurol 1990 Mar-Apr;6(2):102-8. doi: 10.1016/0887-8994(90)90042-y. PMID: 2340026
Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low dose pulsatile gonadotrophin releasing hormone treatment of hypogonadotrophic hypogonadism.
Stanhope R, Adams J, Jacobs HS, Brook CG
Arch Dis Child 1985 Feb;60(2):116-9. doi: 10.1136/adc.60.2.116. PMID: 3883909Free PMC Article

Therapy

Optimal therapy of pubertal disorders in precocious/early puberty.
Tatò L, Savage MO, Antoniazzi F, Buzi F, Di Maio S, Oostdijk W, Pasquino AM, Raiola G, Saenger P, Tonini G, Voorhoeve PG; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:985-95. doi: 10.1515/jpem-2001-s211. PMID: 11529405
Superactive gonadotropin-releasing hormone agonists.
Swerdloff RS, Heber D
Annu Rev Med 1983;34:491-500. doi: 10.1146/annurev.me.34.020183.002423. PMID: 6344774
Treatment of idiopathic precocious puberty with cyproterone acetate. Proceedings of a discussion, Berlin, April 29, 1977.
Horm Res 1978;9(5):301-12. doi: 10.1159/000178925. PMID: 210100
Growth hormone secretion in idiopathic precocious puberty: effect of medroxyprogesterone.
Kaplan S, Frasier SD, Costin G
J Pediatr 1969 Jul;75(1):133-8. doi: 10.1016/s0022-3476(69)80115-0. PMID: 5790396
Treatment of idiopathic precocious puberty in boys.
Schoen EJ
J Clin Endocrinol Metab 1966 Apr;26(4):363-70. doi: 10.1210/jcem-26-4-363. PMID: 5929626

Prognosis

Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Congenital sinus of the upper lip with idiopathic precocious puberty.
Sumitomo S, Ogawa S, Hirai K, Takai Y
Oral Dis 2002 Nov;8(6):308-9. doi: 10.1034/j.1601-0825.2002.02871.x. PMID: 12477063
Do all girls with apparent idiopathic precocious puberty require gonadotropin-releasing hormone agonist treatment?
Léger J, Reynaud R, Czernichow P
J Pediatr 2000 Dec;137(6):819-25. doi: 10.1067/mpd.2000.109201. PMID: 11113839
Idiopathic precocious puberty in girls: psychiatric follow-up in adolescence.
Ehrhardt AA, Meyer-Bahlburg HF, Bell JJ, Cohen SF, Healey JM, Stiel R, Feldman JF, Morishima A, New MI
J Am Acad Child Psychiatry 1984 Jan;23(1):23-33. doi: 10.1097/00004583-198401000-00004. PMID: 6693676
Height predictions in girls with idiopathic precocious puberty by the Bayley-Pinneau method.
Kirkland JL, Gibbs AR, Kirkland RT, Clayton GW
Pediatrics 1981 Aug;68(2):251-2. PMID: 7267233

Clinical prediction guides

Urinary zearalenone levels in girls with premature thelarche and idiopathic central precocious puberty.
Asci A, Durmaz E, Erkekoglu P, Pasli D, Bircan I, Kocer-Gumusel B
Minerva Pediatr 2014 Dec;66(6):571-8. PMID: 25336100
Traditional Chinese medicine for idiopathic precocious puberty: A hospital-based retrospective observational study.
Yu CH, Liu PH, Van YH, Lien AS, Huang TP, Yen HR
Complement Ther Med 2014 Apr;22(2):258-65. Epub 2014 Jan 9 doi: 10.1016/j.ctim.2014.01.002. PMID: 24731897
Clinical review: Constitutional advancement of growth, a.k.a. early growth acceleration, predicts early puberty and childhood obesity.
Papadimitriou A, Nicolaidou P, Fretzayas A, Chrousos GP
J Clin Endocrinol Metab 2010 Oct;95(10):4535-41. Epub 2010 Jul 7 doi: 10.1210/jc.2010-0895. PMID: 20610589
Height predictions in girls with idiopathic precocious puberty by the Bayley-Pinneau method.
Kirkland JL, Gibbs AR, Kirkland RT, Clayton GW
Pediatrics 1981 Aug;68(2):251-2. PMID: 7267233
Growth hormone secretion in idiopathic precocious puberty: effect of medroxyprogesterone.
Kaplan S, Frasier SD, Costin G
J Pediatr 1969 Jul;75(1):133-8. doi: 10.1016/s0022-3476(69)80115-0. PMID: 5790396

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