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Neoplasm of major salivary gland

MedGen UID:
83383
•Concept ID:
C0345599
•
Neoplastic Process
Synonyms: Major Salivary Gland Neoplasm; major salivary gland neoplasm; major salivary gland neoplasm (disease); Major Salivary Gland Tumor; major salivary gland tumor; major salivary gland tumour; Neoplasm of Major Salivary Gland; neoplasm of major salivary gland; Neoplasm of the Major Salivary Gland; neoplasm of the Major salivary gland; Tumor of major salivary gland; Tumor of Major Salivary Gland; tumor of major salivary gland; tumor of Major salivary gland; Tumor of the Major Salivary Gland; tumor of the Major salivary gland; tumour of Major salivary gland; tumour of major salivary gland; tumour of the Major salivary gland
SNOMED CT: Neoplasm of major salivary gland (126787005); Tumor of major salivary gland (126787005)
 
Monarch Initiative: MONDO:0021368

Definition

A benign or malignant neoplasm that affects the major salivary glands. Representative examples of benign neoplasms include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of major salivary gland

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202
Surgical treatment of salivary malignant tumors.
Lombardi D, McGurk M, Vander Poorten V, Guzzo M, Accorona R, Rampinelli V, Nicolai P
Oral Oncol 2017 Feb;65:102-113. Epub 2016 Dec 22 doi: 10.1016/j.oraloncology.2016.12.007. PMID: 28017651

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202
Management of salivary gland carcinomas - a review.
Wang X, Luo Y, Li M, Yan H, Sun M, Fan T
Oncotarget 2017 Jan 17;8(3):3946-3956. doi: 10.18632/oncotarget.13952. PMID: 27992367Free PMC Article
Cancers of major salivary glands.
Panwar A, Kozel JA, Lydiatt WM
Surg Oncol Clin N Am 2015 Jul;24(3):615-33. doi: 10.1016/j.soc.2015.03.011. PMID: 25979403

Diagnosis

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Salivary Gland Malignancies.
Carlson ER, Schlieve T
Oral Maxillofac Surg Clin North Am 2019 Feb;31(1):125-144. doi: 10.1016/j.coms.2018.08.007. PMID: 30449524
CT and MR imaging findings of palatal tumors.
Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674

Therapy

Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy.
Ruigrok EAM, van Vliet N, Dalm SU, de Blois E, van Gent DC, Haeck J, de Ridder C, Stuurman D, Konijnenberg MW, van Weerden WM, de Jong M, Nonnekens J
Eur J Nucl Med Mol Imaging 2021 May;48(5):1339-1350. Epub 2020 Oct 23 doi: 10.1007/s00259-020-05057-6. PMID: 33094433Free PMC Article
Current State of Knowledge on Salivary Gland Cancers.
Lin HH, Limesand KH, Ann DK
Crit Rev Oncog 2018;23(3-4):139-151. doi: 10.1615/CritRevOncog.2018027598. PMID: 30311570Free PMC Article
Parotidectomy--Anatomical considerations.
Wang SJ, Eisele DW
Clin Anat 2012 Jan;25(1):12-8. Epub 2011 Jun 10 doi: 10.1002/ca.21209. PMID: 21671284
Major and minor salivary gland tumors.
Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L
Crit Rev Oncol Hematol 2010 May;74(2):134-48. Epub 2009 Nov 24 doi: 10.1016/j.critrevonc.2009.10.004. PMID: 19939701
Graft-vs.-host disease.
Woo SB, Lee SJ, Schubert MM
Crit Rev Oral Biol Med 1997;8(2):201-16. doi: 10.1177/10454411970080020701. PMID: 9167093

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Jun;41(3):206-214. doi: 10.14639/0392-100X-N1379. PMID: 34264913Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Guidelines for Clinical Target Volume Definition for Perineural Spread of Major Salivary Gland Cancers.
Armstrong K, Ward J, Hughes NM, Mihai A, Blayney A, Mascott C, Kileen R, Armstrong J
Clin Oncol (R Coll Radiol) 2018 Dec;30(12):773-779. Epub 2018 Sep 14 doi: 10.1016/j.clon.2018.08.018. PMID: 30224202
Primary Salivary Gland Type Tumors of the Thymus.
Kalhor N, Weissferdt A, Moran CA
Adv Anat Pathol 2017 Jan;24(1):15-23. doi: 10.1097/PAP.0000000000000132. PMID: 27941539
Cancers of major salivary glands.
Panwar A, Kozel JA, Lydiatt WM
Surg Oncol Clin N Am 2015 Jul;24(3):615-33. doi: 10.1016/j.soc.2015.03.011. PMID: 25979403

Clinical prediction guides

Microsecretory Adenocarcinoma of Salivary Glands.
Bishop JA, Sajed DP
Adv Anat Pathol 2023 Mar 1;30(2):130-135. Epub 2022 Dec 19 doi: 10.1097/PAP.0000000000000385. PMID: 36729381
Margins for Benign Salivary Gland Neoplasms of the Head and Neck.
Carlson ER, McCoy JM
Oral Maxillofac Surg Clin North Am 2017 Aug;29(3):325-340. doi: 10.1016/j.coms.2017.03.009. PMID: 28709532
Advances in salivary gland gene therapy - oral and systemic implications.
Baum BJ, Alevizos I, Chiorini JA, Cotrim AP, Zheng C
Expert Opin Biol Ther 2015;15(10):1443-54. Epub 2015 Jul 6 doi: 10.1517/14712598.2015.1064894. PMID: 26149284Free PMC Article
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197
Pitfalls in the staging of cancer of the major salivary gland neoplasms.
Friedman ER, Saindane AM
Neuroimaging Clin N Am 2013 Feb;23(1):107-22. doi: 10.1016/j.nic.2012.08.009. PMID: 23199664

Recent systematic reviews

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Impact of tumor site on the prognosis of salivary gland neoplasms: A systematic review and meta-analysis.
Dos Santos ES, Rodrigues-Fernandes CI, Speight PM, Khurram SA, Alsanie I, Costa Normando AG, Prado-Ribeiro AC, Brandão TB, Kowalski LP, Silva Guerra EN, Lopes MA, Vargas PA, Santos-Silva AR, Leme AFP
Crit Rev Oncol Hematol 2021 Jun;162:103352. Epub 2021 May 12 doi: 10.1016/j.critrevonc.2021.103352. PMID: 33991662
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.
Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410

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