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Mesenchymal hamartoma

MedGen UID:
83108
•Concept ID:
C0334090
•
Disease or Syndrome
Synonyms: Mesenchymal Hamartoma; mesenchymal hamartoma
SNOMED CT: Mesenchymal hamartoma (80656004)
 
Monarch Initiative: MONDO:0024478

Definition

A hamartoma characterized by the presence of mesenchymal elements. [from NCI]

Professional guidelines

PubMed

Pediatric Hepatic Cystic Lesions: Differential Diagnosis and Multimodality Imaging Approach.
Riedesel EL, Richer EJ, Taylor SD, Tao T, Gagnon MH, Braithwaite KA, Alazraki AL, Khanna G
Radiographics 2022 Sep-Oct;42(5):1514-1531. Epub 2022 Jul 15 doi: 10.1148/rg.220006. PMID: 35839138
Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993
Pitfalls in the surgical management of undifferentiated sarcoma of the liver and benefits of preoperative chemotherapy.
Merli L, Mussini C, Gabor F, Branchereau S, Martelli H, Pariente D, Guérin F
Eur J Pediatr Surg 2015 Feb;25(1):132-7. Epub 2014 Sep 26 doi: 10.1055/s-0034-1387937. PMID: 25259441

Recent clinical studies

Etiology

(18)F-FDG PET/CT findings of mesenchymal hamartoma of the liver in an adolescent.
Yu C, Wu S, Dou X, Zhao S, Zhang H, Tian M
Eur J Nucl Med Mol Imaging 2022 Nov;49(13):4748-4749. Epub 2022 Jun 25 doi: 10.1007/s00259-022-05874-x. PMID: 35751665
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Rhabdomyomatous mesenchymal hamartoma.
Ortak T, Orbay H, Unlü E, Uysal C, Uraloğlu M, Sensöz OM
J Craniofac Surg 2005 Nov;16(6):1135-7. doi: 10.1097/01.scs.0000183468.93084.ba. PMID: 16327571
Mesenchymal hamartoma of the liver: a systematic review.
Stringer MD, Alizai NK
J Pediatr Surg 2005 Nov;40(11):1681-90. doi: 10.1016/j.jpedsurg.2005.07.052. PMID: 16291152
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Rhabdomyomatous Mesenchymal Hamartoma: A New Proposed Clinical Classification of Adult Onset Acquired Type.
Ehara Y, Yoshida Y, Kataoka S, Yoshioka I, Yamamoto O
Acta Derm Venereol 2022 Jan 5;102:adv00627. doi: 10.2340/actadv.v101.170. PMID: 34904686Free PMC Article
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Rhabdomyomatous mesenchymal hamartoma.
Ortak T, Orbay H, Unlü E, Uysal C, Uraloğlu M, Sensöz OM
J Craniofac Surg 2005 Nov;16(6):1135-7. doi: 10.1097/01.scs.0000183468.93084.ba. PMID: 16327571
Hepatic mesenchymal hamartoma.
Yen JB, Kong MS, Lin JN
J Paediatr Child Health 2003 Nov;39(8):632-4. doi: 10.1046/j.1440-1754.2003.00250.x. PMID: 14629534

Therapy

Rhabdomyomatous mesenchymal hamartoma: clinical overview and report of a case with spontaneous regression.
Williams NP, Shue AC
West Indian Med J 2009 Dec;58(6):607-9. PMID: 20583694
Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review.
Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA
Ophthalmology 2001 Apr;108(4):798-804. doi: 10.1016/s0161-6420(00)00638-2. PMID: 11297501
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature.
Ramanujam TM, Ramesh JC, Goh DW, Wong KT, Ariffin WA, Kumar G, Taib NA
J Pediatr Surg 1999 Nov;34(11):1684-6. doi: 10.1016/s0022-3468(99)90644-9. PMID: 10591570
Mesenchymal hamartoma of the liver responsive to cyclophosphamide therapy: therapeutic approach.
Alkalay AL, Puri AR, Pomerance JJ, Kallus M, Gans SL, Hurvitz CH, Farber SJ, Sloninsky L
J Pediatr Surg 1985 Apr;20(2):125-8. doi: 10.1016/s0022-3468(85)80283-9. PMID: 4009357

Prognosis

Rhabdomyomatous mesenchymal hamartoma.
Ortak T, Orbay H, Unlü E, Uysal C, Uraloğlu M, Sensöz OM
J Craniofac Surg 2005 Nov;16(6):1135-7. doi: 10.1097/01.scs.0000183468.93084.ba. PMID: 16327571
Mesenchymal hamartoma of the liver: a systematic review.
Stringer MD, Alizai NK
J Pediatr Surg 2005 Nov;40(11):1681-90. doi: 10.1016/j.jpedsurg.2005.07.052. PMID: 16291152
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478

Clinical prediction guides

Liver transplantation for primary liver tumors in pediatrics. A case series.
Selzer Soria EM, González Campaña A, Siaba Serrate A, Varela M, Lagues C, Fauda M, Malla I
Arch Argent Pediatr 2025 Feb 1;123(1):e202310222. Epub 2024 Aug 1 doi: 10.5546/aap.2023-10222.eng. PMID: 39058378
Proptosis Caused by Rhabdomyomatous Mesenchymal Hamartomata Occurring in the Orbit.
Phan IT, Courtney RJ, Marx DP, Wilson DJ, Mansoor A, Ng JD
Ophthalmic Plast Reconstr Surg 2016 May-Jun;32(3):e62-4. doi: 10.1097/IOP.0000000000000246. PMID: 25105519
Benign liver tumors in pediatric patients - Review with emphasis on imaging features.
Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, Schreiber-Dietrich D, Jüngert J, Chang JM, Dietrich CF
World J Gastroenterol 2015 Jul 28;21(28):8541-61. doi: 10.3748/wjg.v21.i28.8541. PMID: 26229397Free PMC Article
Hepatic neoplasms in childhood - a clinicopathologic study.
Bhattacharya S, Lobo FD, Pai PK, Pai GK
Pediatr Surg Int 1998 Nov;14(1-2):51-4. doi: 10.1007/s003830050434. PMID: 9880696
Infantile mesenchymal hamartoma of the liver. Histologic and ultrastructural observations.
Dehner LP, Ewing SL, Sumner HW
Arch Pathol 1975 Jul;99(7):379-82. PMID: 1170838

Recent systematic reviews

Outcomes of Primary Tumor Excision do not Differ from Non-Resection Methods in Pediatric Mesenchymal Hamartoma of the Liver: A Rapid Systematic Review.
Bauzon J, Froehlich M, Dadon N, Morris D, Chang S
J Pediatr Surg 2023 Dec;58(12):2356-2361. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.012. PMID: 37775408
Liver Transplant for Adult Recurrent Hepatic Mesenchymal Hamartoma and a Feasible Treatment Modality: A Case Report and Literature Review.
Idrees M, Chung K, Philipoff A, Jeffrey G, Garas G, Jaques B, Delriviere L, De Boer B, Bhandari M, Mou L
Transplant Proc 2022 Jul-Aug;54(6):1636-1639. Epub 2022 Jul 14 doi: 10.1016/j.transproceed.2022.04.020. PMID: 35842317
En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
Meng T, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, Liu T, Song D, Xiao J
World J Surg Oncol 2015 May 8;13:176. doi: 10.1186/s12957-015-0589-3. PMID: 25951872Free PMC Article
Mesenchymal hamartoma of the liver: a systematic review.
Stringer MD, Alizai NK
J Pediatr Surg 2005 Nov;40(11):1681-90. doi: 10.1016/j.jpedsurg.2005.07.052. PMID: 16291152

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