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Dipsogenic diabetes insipidus

MedGen UID:
82829
•Concept ID:
C0268813
•
Disease or Syndrome
Synonym: Dipsogenic Diabetes Insipidus
SNOMED CT: Dipsogenic diabetes insipidus (82800008); Primary polydipsia (82800008)
 
Monarch Initiative: MONDO:0022993

Definition

Diabetes insipidus caused by excessive intake of water due to psychological factors or damage to the thirst-regulating mechanism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDipsogenic diabetes insipidus

Professional guidelines

PubMed

Diagnosis and differential diagnosis of diabetes insipidus: Update.
Refardt J
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101398. Epub 2020 Feb 28 doi: 10.1016/j.beem.2020.101398. PMID: 32387127
Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests.
Fenske W, Quinkler M, Lorenz D, Zopf K, Haagen U, Papassotiriou J, Pfeiffer AF, Fassnacht M, Störk S, Allolio B
J Clin Endocrinol Metab 2011 May;96(5):1506-15. Epub 2011 Mar 2 doi: 10.1210/jc.2010-2345. PMID: 21367924

Recent clinical studies

Etiology

Primary polydipsia: Update.
Ahmadi L, Goldman MB
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101469. Epub 2020 Oct 14 doi: 10.1016/j.beem.2020.101469. PMID: 33222764Free PMC Article
Diagnostic value of the water deprivation test in the polyuria-polydipsia syndrome.
Trimpou P, Olsson DS, Ehn O, Ragnarsson O
Hormones (Athens) 2017 Oct;16(4):414-422. doi: 10.14310/horm.2002.1762. PMID: 29518762
Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
Sailer C, Winzeler B, Christ-Crain M
Swiss Med Wkly 2017;147:w14514. Epub 2017 Nov 1 doi: 10.4414/smw.2017.14514. PMID: 29120013

Diagnosis

Primary polydipsia: Update.
Ahmadi L, Goldman MB
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101469. Epub 2020 Oct 14 doi: 10.1016/j.beem.2020.101469. PMID: 33222764Free PMC Article
Diabetes Insipidus: An Update.
Refardt J, Winzeler B, Christ-Crain M
Endocrinol Metab Clin North Am 2020 Sep;49(3):517-531. Epub 2020 Jul 15 doi: 10.1016/j.ecl.2020.05.012. PMID: 32741486
Diagnosis and differential diagnosis of diabetes insipidus: Update.
Refardt J
Best Pract Res Clin Endocrinol Metab 2020 Sep;34(5):101398. Epub 2020 Feb 28 doi: 10.1016/j.beem.2020.101398. PMID: 32387127
Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
Sailer C, Winzeler B, Christ-Crain M
Swiss Med Wkly 2017;147:w14514. Epub 2017 Nov 1 doi: 10.4414/smw.2017.14514. PMID: 29120013
Dipsogenic diabetes insipidus: report of a novel treatment strategy and literature review.
Perkins RM, Yuan CM, Welch PG
Clin Exp Nephrol 2006 Mar;10(1):63-7. doi: 10.1007/s10157-005-0397-0. PMID: 16544179

Therapy

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold.
Richter HG, Freichel C, Huwyler J, Nakagawa T, Nettekoven M, Plancher JM, Raab S, Roche O, Schuler F, Taylor S, Ullmer C, Wiegand R
Bioorg Med Chem Lett 2010 Oct 1;20(19):5713-7. Epub 2010 Aug 6 doi: 10.1016/j.bmcl.2010.08.009. PMID: 20801030
Dipsogenic diabetes insipidus: report of a novel treatment strategy and literature review.
Perkins RM, Yuan CM, Welch PG
Clin Exp Nephrol 2006 Mar;10(1):63-7. doi: 10.1007/s10157-005-0397-0. PMID: 16544179
Acute water intoxication after intranasal desmopressin in a patient with primary polydispsia.
Ferrer J, Halperin I, Conget JI, Cabrer J, Esmatjes E, Vilardell E
J Endocrinol Invest 1990 Sep;13(8):663-6. doi: 10.1007/BF03349590. PMID: 2273207

Prognosis

Diagnostic value of the water deprivation test in the polyuria-polydipsia syndrome.
Trimpou P, Olsson DS, Ehn O, Ragnarsson O
Hormones (Athens) 2017 Oct;16(4):414-422. doi: 10.14310/horm.2002.1762. PMID: 29518762

Clinical prediction guides

Diagnostic value of the water deprivation test in the polyuria-polydipsia syndrome.
Trimpou P, Olsson DS, Ehn O, Ragnarsson O
Hormones (Athens) 2017 Oct;16(4):414-422. doi: 10.14310/horm.2002.1762. PMID: 29518762

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