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Vascular ectasia of gastric antrum(GAVE)

MedGen UID:: 82753
•Concept ID:: C0267211
•: Disease or Syndrome

Synonyms:	Gastric antral vascular ectasia; GAVE; Watermelon stomach
SNOMED CT:	GAVE - Gastric antral vascular ectasia (43935004); Vascular ectasia of gastric antrum (43935004); Watermelon stomach (43935004)

Monarch Initiative:	MONDO:0006767

Definition

Dilatation of the vessels in the antrum of the stomach. It is associated with portal hypertension, scleroderma, and chronic renal failure. It may cause gastric bleeding. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVascular ectasia of gastric antrum

Pathological process
- Disease
  - Disorder by Site
    - Disorder of cardiovascular system
      - Vascular disorder
        Angiodysplasia
        Vascular ectasia of gastric antrum

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.

DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796

A Practical Approach to the Management of Gastric Antral Vascular Ectasia.

Meyers MH, Rodriguez L, Kriss MS
Am J Gastroenterol 2023 Sep 1;118(9):1532-1535. Epub 2023 Apr 11 doi: 10.14309/ajg.0000000000002290. PMID: 37040555

Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review.

Peng M, Guo X, Yi F, Romeiro FG, Mancuso A, Qi X
Adv Ther 2021 Oct;38(10):5065-5077. Epub 2021 Sep 15 doi: 10.1007/s12325-021-01912-6. PMID: 34524644

See all (42)

Recent clinical studies

Etiology

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.

DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.

Cavazzana I, Vojinovic T, Airo' P, Fredi M, Ceribelli A, Pedretti E, Lazzaroni MG, Garrafa E, Franceschini F
Clin Rev Allergy Immunol 2023 Jun;64(3):412-430. Epub 2022 Jun 18 doi: 10.1007/s12016-022-08946-w. PMID: 35716254 Free PMC Article

Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review.

Peng M, Guo X, Yi F, Romeiro FG, Mancuso A, Qi X
Adv Ther 2021 Oct;38(10):5065-5077. Epub 2021 Sep 15 doi: 10.1007/s12325-021-01912-6. PMID: 34524644

Diagnosis and Management of Gastric Antral Vascular Ectasia: Experience in a Large Single Cohort of Patients With Systemic Sclerosis.

Assad APL, Farias R, Gaspari CN, da Silva HC, Andrade DCO, Sampaio-Barros PD
J Clin Rheumatol 2020 Mar;26(2):79-81. doi: 10.1097/RHU.0000000000000927. PMID: 32073520

Watermelon stomach.

Chatterjee S
CMAJ 2008 Jul 15;179(2):162. doi: 10.1503/cmaj.080461. PMID: 18625989 Free PMC Article

See all (120)

Diagnosis

A Practical Approach to the Management of Gastric Antral Vascular Ectasia.

Meyers MH, Rodriguez L, Kriss MS
Am J Gastroenterol 2023 Sep 1;118(9):1532-1535. Epub 2023 Apr 11 doi: 10.14309/ajg.0000000000002290. PMID: 37040555

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.

Gastrointestinal bleeding.

Dinis-Ribeiro M
Gastrointest Endosc 2013 Sep;78(3):434-8. doi: 10.1016/j.gie.2013.06.021. PMID: 23948192

Watermelon stomach.

Chatterjee S
CMAJ 2008 Jul 15;179(2):162. doi: 10.1503/cmaj.080461. PMID: 18625989 Free PMC Article

Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome.

Burak KW, Lee SS, Beck PL
Gut 2001 Dec;49(6):866-72. doi: 10.1136/gut.49.6.866. PMID: 11709525 Free PMC Article

See all (203)

Therapy

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.

DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796

Gastrointestinal bleeding.

Dinis-Ribeiro M
Endoscopy 2013 Sep;45(9):740-4. Epub 2013 Aug 29 doi: 10.1055/s-0033-1344626. PMID: 23990485

Gastrointestinal bleeding.

Dinis-Ribeiro M
Gastrointest Endosc 2013 Sep;78(3):434-8. doi: 10.1016/j.gie.2013.06.021. PMID: 23948192

Watermelon stomach.

Chatterjee S
CMAJ 2008 Jul 15;179(2):162. doi: 10.1503/cmaj.080461. PMID: 18625989 Free PMC Article

Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome.

Burak KW, Lee SS, Beck PL
Gut 2001 Dec;49(6):866-72. doi: 10.1136/gut.49.6.866. PMID: 11709525 Free PMC Article

See all (114)

Prognosis

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.

An update on biomarker discovery and use in systemic sclerosis.

Matsushita T, Takehara K
Expert Rev Mol Diagn 2017 Sep;17(9):823-833. Epub 2017 Jul 25 doi: 10.1080/14737159.2017.1356722. PMID: 28730919

Watermelon stomach.

Chatterjee S
CMAJ 2008 Jul 15;179(2):162. doi: 10.1503/cmaj.080461. PMID: 18625989 Free PMC Article

Endoscopic band ligation: a novel therapy for bleeding gastric antral vascular ectasia.

Kumar R, Mohindra S, Pruthi HS
Endoscopy 2007 Feb;39 Suppl 1:E56-7. Epub 2007 Feb 26 doi: 10.1055/s-2006-945121. PMID: 17323279

Gastric intestinal vascular ectasia syndrome: findings on capsule endoscopy.

Tang SJ, Zanati S, Kandel G, Marcon NE, Kortan P
Endoscopy 2005 Dec;37(12):1244-7. doi: 10.1055/s-2005-870268. PMID: 16329025

See all (72)

Clinical prediction guides

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.

An update on biomarker discovery and use in systemic sclerosis.

Matsushita T, Takehara K
Expert Rev Mol Diagn 2017 Sep;17(9):823-833. Epub 2017 Jul 25 doi: 10.1080/14737159.2017.1356722. PMID: 28730919

Portal hypertensive gastropathy and gastric antral vascular ectasia.

Garg H, Gupta S, Anand AC, Broor SL
Indian J Gastroenterol 2015 Sep;34(5):351-8. Epub 2015 Nov 13 doi: 10.1007/s12664-015-0605-0. PMID: 26564121

Portal hypertensive gastropathy.

Negreanu L, Buşegeanu C, Trandafir D, Dragomir P, Udeanu M, Fierbinţeanu-Braticevici C, Andronescu D
Rom J Intern Med 2005;43(1-2):3-8. PMID: 16739861

Watermelon stomach.

Abedi M, Haber GB
Gastroenterologist 1997 Sep;5(3):179-84. PMID: 9298372

See all (69)

Recent systematic reviews

Endoscopic band ligation in the treatment of gastric antral vascular ectasia: a systematic review and meta-analysis.

Mohan BP, Toy G, Kassab LL, Ponnada S, Chandan S, Parbhu S, Chandna S, Adler DG
Gastrointest Endosc 2021 Dec;94(6):1021-1029.e10. Epub 2021 Sep 1 doi: 10.1016/j.gie.2021.08.017. PMID: 34480922

Endoscopic band ligation compared to thermal therapy for gastric antral vascular ectasia: A systematic review and meta-analysis.

Chalhoub JM, Umar J, Groudan K, Hamadeh N, Desilets DJ, Greeff Y
United European Gastroenterol J 2021 Mar;9(2):150-158. Epub 2021 Feb 18 doi: 10.1177/2050640620975243. PMID: 33210983 Free PMC Article

Comparative Effectiveness and Safety of Radiofrequency Ablation Versus Argon Plasma Coagulation for Treatment of Gastric Antral Vascular Ectasia: A Systematic Review and Meta-Analysis.

McCarty TR, Rustagi T
J Clin Gastroenterol 2019 Sep;53(8):599-606. doi: 10.1097/MCG.0000000000001088. PMID: 29952856

Medical and endoscopic therapies for angiodysplasia and gastric antral vascular ectasia: a systematic review.

Swanson E, Mahgoub A, MacDonald R, Shaukat A
Clin Gastroenterol Hepatol 2014 Apr;12(4):571-82. Epub 2013 Sep 5 doi: 10.1016/j.cgh.2013.08.038. PMID: 24013107

See all (4)

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Vascular ectasia of gastric antrum(GAVE)

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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