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Malignant Ossifying Fibromyxoid Tumor

MedGen UID:
825800
•Concept ID:
C3839955
•
Neoplastic Process
Synonyms: Malignant ossifying fibromyxoid tumor; Ossifying fibromyxoid tumor, malignant
SNOMED CT: Ossifying fibromyxoid tumor, malignant (703631004); Malignant ossifying fibromyxoid tumor (1292988006)

Definition

An ossifying fibromyxoid tumor characterized by the presence of high grade nuclear features or increased cellularity and more than two mitotic figures per 50 HPFs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ossifying Fibromyxoid Tumor

Professional guidelines

PubMed

Ossifying Fibromyxoid Tumor: A Review With Emphasis on Recent Molecular Advances and Differential Diagnosis.
Carter CS, Patel RM
Arch Pathol Lab Med 2019 Dec;143(12):1504-1512. doi: 10.5858/arpa.2019-0371-RA. PMID: 31765250
Diagnosis and management of benign fibro-osseous lesions of the jaws: a current review for the dental clinician.
Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Schneider N, Fisher C, Thway K
Ann Diagn Pathol 2016 Feb;20:52-8. Epub 2015 Dec 2 doi: 10.1016/j.anndiagpath.2015.11.002. PMID: 26732302

Recent clinical studies

Etiology

When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
Sharma AE, Dermawan JK, Sherrod AE, Chopra S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2024 Jan;63(1):e23206. Epub 2023 Oct 11 doi: 10.1002/gcc.23206. PMID: 37819540Free PMC Article
A Case of an 82-Year-Old Man with a Spinal Extradural Malignant Ossifying Fibromyxoid Tumor.
Lu Q, Ho CL
Am J Case Rep 2023 May 23;24:e939408. doi: 10.12659/AJCR.939408. PMID: 37218126Free PMC Article

Diagnosis

When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion.
Sharma AE, Dermawan JK, Sherrod AE, Chopra S, Maki RG, Antonescu CR
Genes Chromosomes Cancer 2024 Jan;63(1):e23206. Epub 2023 Oct 11 doi: 10.1002/gcc.23206. PMID: 37819540Free PMC Article
A Case of an 82-Year-Old Man with a Spinal Extradural Malignant Ossifying Fibromyxoid Tumor.
Lu Q, Ho CL
Am J Case Rep 2023 May 23;24:e939408. doi: 10.12659/AJCR.939408. PMID: 37218126Free PMC Article
Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature.
Ohta K, Taki M, Ogawa I, Ono S, Mizuta K, Fujimoto S, Takata T, Kamata N
Head Face Med 2013 Jun 24;9:16. doi: 10.1186/1746-160X-9-16. PMID: 23800162Free PMC Article
Cutaneous malignant ossifying fibromyxoid tumor.
Cibull TL, Billings SD
Am J Dermatopathol 2007 Apr;29(2):156-9. doi: 10.1097/01.dad.0000211530.26047.2b. PMID: 17414437
Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor.
Suehiro K, Pritzwald-Stegmann P, Lee KM, Teoh HH, Alison PM
Ann Thorac Surg 2006 Jun;81(6):2289-91. doi: 10.1016/j.athoracsur.2005.07.098. PMID: 16731174

Prognosis

A Case of an 82-Year-Old Man with a Spinal Extradural Malignant Ossifying Fibromyxoid Tumor.
Lu Q, Ho CL
Am J Case Rep 2023 May 23;24:e939408. doi: 10.12659/AJCR.939408. PMID: 37218126Free PMC Article
Malignant ossifying fibromyxoid tumor of the tongue: case report and review of the literature.
Ohta K, Taki M, Ogawa I, Ono S, Mizuta K, Fujimoto S, Takata T, Kamata N
Head Face Med 2013 Jun 24;9:16. doi: 10.1186/1746-160X-9-16. PMID: 23800162Free PMC Article
Mediastinal and pulmonary metastases of malignant ossifying fibromyxoid tumor.
Suehiro K, Pritzwald-Stegmann P, Lee KM, Teoh HH, Alison PM
Ann Thorac Surg 2006 Jun;81(6):2289-91. doi: 10.1016/j.athoracsur.2005.07.098. PMID: 16731174

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