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Antepartum Obstetric Thromboembolism

MedGen UID:
824274
•Concept ID:
C3831526
•
Disease or Syndrome

Definition

Presence of a blood clot in the maternal vascular system which originated from a distant site during the antepartum period. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAntepartum Obstetric Thromboembolism

Professional guidelines

PubMed

Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.
Maughan BC, Marin M, Han J, Gibbins KJ, Brixey AG, Caughey AB, Kline JA, Jarman AF
Obstet Gynecol Surv 2022 Jul;77(7):433-444. doi: 10.1097/OGX.0000000000001043. PMID: 35792687Free PMC Article
American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.
Bates SM, Rajasekhar A, Middeldorp S, McLintock C, Rodger MA, James AH, Vazquez SR, Greer IA, Riva JJ, Bhatt M, Schwab N, Barrett D, LaHaye A, Rochwerg B
Blood Adv 2018 Nov 27;2(22):3317-3359. doi: 10.1182/bloodadvances.2018024802. PMID: 30482767Free PMC Article
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO
Chest 2012 Feb;141(2 Suppl):e691S-e736S. doi: 10.1378/chest.11-2300. PMID: 22315276Free PMC Article

Recent clinical studies

Etiology

Anticoagulation Regimens in Pregnancy.
Saad A, Safarzadeh M, Shepherd M
Obstet Gynecol Clin North Am 2023 Mar;50(1):241-249. doi: 10.1016/j.ogc.2022.10.010. PMID: 36822707
Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial.
Bistervels IM, Buchmüller A, Wiegers HMG, Ní Áinle F, Tardy B, Donnelly J, Verhamme P, Jacobsen AF, Hansen AT, Rodger MA, DeSancho MT, Shmakov RG, van Es N, Prins MH, Chauleur C, Middeldorp S; Highlow Block writing committee; Highlow Investigators
Lancet 2022 Nov 19;400(10365):1777-1787. Epub 2022 Oct 28 doi: 10.1016/S0140-6736(22)02128-6. PMID: 36354038
Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.
Maughan BC, Marin M, Han J, Gibbins KJ, Brixey AG, Caughey AB, Kline JA, Jarman AF
Obstet Gynecol Surv 2022 Jul;77(7):433-444. doi: 10.1097/OGX.0000000000001043. PMID: 35792687Free PMC Article
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO
Chest 2012 Feb;141(2 Suppl):e691S-e736S. doi: 10.1378/chest.11-2300. PMID: 22315276Free PMC Article

Diagnosis

Postpartum pharmacologic thromboprophylaxis and complications in a US cohort.
Bruno AM, Sandoval GJ, Hughes BL, Grobman WA, Saade GR, Manuck TA, Longo M, Metz TD, Simhan HN, Rouse DJ, Mendez-Figueroa H, Gyamfi-Bannerman C, Bailit JL, Costantine MM, Sehdev HM, Tita ATN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, MD
Am J Obstet Gynecol 2024 Jul;231(1):128.e1-128.e11. Epub 2024 Feb 12 doi: 10.1016/j.ajog.2023.11.013. PMID: 38346912Free PMC Article
Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.
Maughan BC, Marin M, Han J, Gibbins KJ, Brixey AG, Caughey AB, Kline JA, Jarman AF
Obstet Gynecol Surv 2022 Jul;77(7):433-444. doi: 10.1097/OGX.0000000000001043. PMID: 35792687Free PMC Article
Incidence of and risk factors for thromboembolism during pregnancy and postpartum: A 10-year nationwide population-based study.
Park JE, Park Y, Yuk JS
Taiwan J Obstet Gynecol 2021 Jan;60(1):103-110. doi: 10.1016/j.tjog.2020.11.016. PMID: 33494981
American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.
Bates SM, Rajasekhar A, Middeldorp S, McLintock C, Rodger MA, James AH, Vazquez SR, Greer IA, Riva JJ, Bhatt M, Schwab N, Barrett D, LaHaye A, Rochwerg B
Blood Adv 2018 Nov 27;2(22):3317-3359. doi: 10.1182/bloodadvances.2018024802. PMID: 30482767Free PMC Article
Peripartum pulmonary embolism.
Miller MA, Chalhoub M, Bourjeily G
Clin Chest Med 2011 Mar;32(1):147-164. doi: 10.1016/j.ccm.2010.11.005. PMID: 21277456

Therapy

Anticoagulation Regimens in Pregnancy.
Saad A, Safarzadeh M, Shepherd M
Obstet Gynecol Clin North Am 2023 Mar;50(1):241-249. doi: 10.1016/j.ogc.2022.10.010. PMID: 36822707
Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial.
Bistervels IM, Buchmüller A, Wiegers HMG, Ní Áinle F, Tardy B, Donnelly J, Verhamme P, Jacobsen AF, Hansen AT, Rodger MA, DeSancho MT, Shmakov RG, van Es N, Prins MH, Chauleur C, Middeldorp S; Highlow Block writing committee; Highlow Investigators
Lancet 2022 Nov 19;400(10365):1777-1787. Epub 2022 Oct 28 doi: 10.1016/S0140-6736(22)02128-6. PMID: 36354038
Venous Thromboembolism During Pregnancy and the Postpartum Period: Risk Factors, Diagnostic Testing, and Treatment.
Maughan BC, Marin M, Han J, Gibbins KJ, Brixey AG, Caughey AB, Kline JA, Jarman AF
Obstet Gynecol Surv 2022 Jul;77(7):433-444. doi: 10.1097/OGX.0000000000001043. PMID: 35792687Free PMC Article
American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.
Bates SM, Rajasekhar A, Middeldorp S, McLintock C, Rodger MA, James AH, Vazquez SR, Greer IA, Riva JJ, Bhatt M, Schwab N, Barrett D, LaHaye A, Rochwerg B
Blood Adv 2018 Nov 27;2(22):3317-3359. doi: 10.1182/bloodadvances.2018024802. PMID: 30482767Free PMC Article
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO
Chest 2012 Feb;141(2 Suppl):e691S-e736S. doi: 10.1378/chest.11-2300. PMID: 22315276Free PMC Article

Prognosis

Expert review: prevention of obstetrical venous thromboembolism.
Friedman AM, D'Alton ME
Am J Obstet Gynecol 2021 Sep;225(3):228-236. Epub 2021 May 8 doi: 10.1016/j.ajog.2021.05.004. PMID: 33974905
Incidence of and risk factors for thromboembolism during pregnancy and postpartum: A 10-year nationwide population-based study.
Park JE, Park Y, Yuk JS
Taiwan J Obstet Gynecol 2021 Jan;60(1):103-110. doi: 10.1016/j.tjog.2020.11.016. PMID: 33494981
Sex matters: Practice 5P's when treating young women with venous thromboembolism.
Bistervels IM, Scheres LJJ, Hamulyák EN, Middeldorp S
J Thromb Haemost 2019 Sep;17(9):1417-1429. Epub 2019 Jul 23 doi: 10.1111/jth.14549. PMID: 31220399Free PMC Article
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Peripartum pulmonary embolism.
Miller MA, Chalhoub M, Bourjeily G
Clin Chest Med 2011 Mar;32(1):147-164. doi: 10.1016/j.ccm.2010.11.005. PMID: 21277456

Clinical prediction guides

Swedish obstetric thromboprophylaxis guideline: background and update.
Lindqvist PG, Westerlund E, Hellgren M
J Obstet Gynaecol 2023 Dec;43(2):2241527. doi: 10.1080/01443615.2023.2241527. PMID: 37551130
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Epidemiology of venous thromboembolism (VTE) associated with pregnancy.
Parunov LA, Soshitova NP, Ovanesov MV, Panteleev MA, Serebriyskiy II
Birth Defects Res C Embryo Today 2015 Sep;105(3):167-84. Epub 2015 Sep 25 doi: 10.1002/bdrc.21105. PMID: 26406886
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO
Chest 2012 Feb;141(2 Suppl):e691S-e736S. doi: 10.1378/chest.11-2300. PMID: 22315276Free PMC Article
Obesity in pregnancy.
Davies GAL, Maxwell C, McLeod L; MATERNAL FETAL MEDICINE COMMITTEE; CLINICAL PRACTICE OBSTETRICS
J Obstet Gynaecol Can 2010 Feb;32(2):165-173. doi: 10.1016/S1701-2163(16)34432-2. PMID: 20181319

Recent systematic reviews

Adverse perinatal pregnancy outcomes in women with schizophrenia: A systematic review and meta-analysis.
Tang W, Zhou LJ, Zhang WQ, Jia YJ, Hu FH, Chen HL
Schizophr Res 2023 Dec;262:156-167. Epub 2023 Nov 16 doi: 10.1016/j.schres.2023.11.001. PMID: 37979419
Risk assessment models for venous thromboembolism in pregnancy and in the puerperium: a systematic review.
Pandor A, Daru J, Hunt BJ, Rooney G, Hamilton J, Clowes M, Goodacre S, Nelson-Piercy C, Davis S
BMJ Open 2022 Oct 12;12(10):e065892. doi: 10.1136/bmjopen-2022-065892. PMID: 36223963Free PMC Article
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis.
Croles FN, Nasserinejad K, Duvekot JJ, Kruip MJ, Meijer K, Leebeek FW
BMJ 2017 Oct 26;359:j4452. doi: 10.1136/bmj.j4452. PMID: 29074563Free PMC Article
Thromboembolism and in vitro fertilization - a systematic review.
Sennström M, Rova K, Hellgren M, Hjertberg R, Nord E, Thurn L, Lindqvist PG
Acta Obstet Gynecol Scand 2017 Sep;96(9):1045-1052. Epub 2017 Jun 8 doi: 10.1111/aogs.13147. PMID: 28382684
Risk of venous thromboembolism in pregnant women with essential thrombocythemia: a systematic review and meta-analysis.
Skeith L, Carrier M, Robinson SE, Alimam S, Rodger MA
Blood 2017 Feb 23;129(8):934-939. Epub 2017 Jan 3 doi: 10.1182/blood-2016-09-728006. PMID: 28049641

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