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Primary Hypoparathyroidism

MedGen UID:
821224
•Concept ID:
C3828476
•
Disease or Syndrome

Definition

Abnormally low levels of parathyroid hormone due to a disorder originating within the parathyroid glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Hypoparathyroidism

Professional guidelines

PubMed

American Association of Clinical Endocrinology Disease State Clinical Review: Evaluation and Management of Immune Checkpoint Inhibitor-Mediated Endocrinopathies: A Practical Case-Based Clinical Approach.
Yuen KCJ, Samson SL, Bancos I, Gosmanov AR, Jasim S, Fecher LA, Weber JS
Endocr Pract 2022 Jul;28(7):719-731. Epub 2022 Apr 25 doi: 10.1016/j.eprac.2022.04.010. PMID: 35477029
The Management of Permanent Primary Hypoparathyroidism in Children and Adolescents: A Complex Task.
De Sanctis V, Soliman AT, Di Maio S, Kattamis C
Pediatr Endocrinol Rev 2018 Sep;16(1):194-202. doi: 10.17458/per.vol16.2018.stsm.hypoparathyroidism. PMID: 30371038
Pathogenesis and management of hypoparathyroidism and other hypocalcemic disorders.
Schneider AB, Sherwood LM
Metabolism 1975 Jul;24(7):871-98. doi: 10.1016/0026-0495(75)90134-1. PMID: 166271

Recent clinical studies

Etiology

Nephrocalcinosis, Renal Dysfunction, and Calculi in Patients With Primary Hypoparathyroidism on Long-Term Conventional Therapy.
Saha S, Kandasamy D, Sharma R, Bal C, Sreenivas V, Goswami R
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz319. PMID: 31901096
Is there a need for an emergency card in hypoparathyroidism?
Astor MC, Zhu W, Björnsdottir S, Bollerslev J, Kämpe O, Husebye ES
J Intern Med 2019 Apr;285(4):429-435. Epub 2018 Dec 12 doi: 10.1111/joim.12865. PMID: 30485554
The Management of Permanent Primary Hypoparathyroidism in Children and Adolescents: A Complex Task.
De Sanctis V, Soliman AT, Di Maio S, Kattamis C
Pediatr Endocrinol Rev 2018 Sep;16(1):194-202. doi: 10.17458/per.vol16.2018.stsm.hypoparathyroidism. PMID: 30371038
Diverse genetic aetiologies and clinical outcomes of paediatric hypoparathyroidism.
Kim JH, Shin YL, Yang S, Cheon CK, Cho JH, Lee BH, Kim GH, Lee JO, Seo EJ, Choi JH, Yoo HW
Clin Endocrinol (Oxf) 2015 Dec;83(6):790-6. Epub 2015 Oct 19 doi: 10.1111/cen.12944. PMID: 26384470
Hypoparathyroidism in pregnancy.
Krysiak R, Kobielusz-Gembala I, Okopien B
Gynecol Endocrinol 2011 Aug;27(8):529-32. Epub 2011 Apr 5 doi: 10.3109/09513590.2010.507284. PMID: 21463229

Diagnosis

Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients.
Yakici N, Kreins AY, Catak MC, Babayeva R, Erman B, Kenney H, Gungor HE, Cea PA, Kawai T, Bosticardo M, Delmonte OM, Adams S, Fan YT, Pala F, Turkyilmaz A, Howley E, Worth A, Kot H, Sefer AP, Kara A, Bulutoglu A, Bilgic-Eltan S, Altunbas MY, Bayram Catak F, Karakus IS, Karatay E, Tekeoglu SD, Eser M, Albayrak D, Citli S, Kiykim A, Karakoc-Aydiner E, Ozen A, Ghosh S, Gohlke H, Orhan F, Notarangelo LD, Davies EG, Baris S
Clin Immunol 2023 Oct;255:109757. Epub 2023 Sep 9 doi: 10.1016/j.clim.2023.109757. PMID: 37689091Free PMC Article
Spectrum of Disorders associated with Tetany.
Santra G
J Assoc Physicians India 2023 Mar;71(3):11-12. doi: 10.5005/japi-11001-0203. PMID: 37354510
Hypoparathyroidism in pregnancy.
Krysiak R, Kobielusz-Gembala I, Okopien B
Gynecol Endocrinol 2011 Aug;27(8):529-32. Epub 2011 Apr 5 doi: 10.3109/09513590.2010.507284. PMID: 21463229
Polyglandular autoimmune syndromes.
Leshin M
Am J Med Sci 1985 Aug;290(2):77-88. doi: 10.1097/00000441-198508000-00007. PMID: 3898841
PRIMARY HYPOPARATHYROIDISM.
MCGILL DA
Proc R Soc Med 1964 Dec;57(12):1125. PMID: 14244887Free PMC Article

Therapy

Spectrum of Disorders associated with Tetany.
Santra G
J Assoc Physicians India 2023 Mar;71(3):11-12. doi: 10.5005/japi-11001-0203. PMID: 37354510
Nephrocalcinosis, Renal Dysfunction, and Calculi in Patients With Primary Hypoparathyroidism on Long-Term Conventional Therapy.
Saha S, Kandasamy D, Sharma R, Bal C, Sreenivas V, Goswami R
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz319. PMID: 31901096
Optic neuritis as presenting primary hypoparathyroidism.
Arshad MF, Karim R, Paling D, Jayamanne G
BMJ Case Rep 2018 Nov 28;11(1) doi: 10.1136/bcr-2018-227032. PMID: 30567123Free PMC Article
Hypoparathyroidism in pregnancy.
Krysiak R, Kobielusz-Gembala I, Okopien B
Gynecol Endocrinol 2011 Aug;27(8):529-32. Epub 2011 Apr 5 doi: 10.3109/09513590.2010.507284. PMID: 21463229
Hypercalcemia and idiopathic hypoparathyroidism.
Schroth M, Dötsch J, Dörr HG
J Clin Pharm Ther 2001 Dec;26(6):453-5. doi: 10.1046/j.1365-2710.2001.00376.x. PMID: 11722683

Prognosis

Case report: a 10-year-old girl with primary hypoparathyroidism and systemic lupus erythematosus.
Borysewicz-Sańczyk H, Sawicka B, Michalak J, Wójtowicz J, Dobreńko E, Konstantynowicz J, Kemp EH, Thakker RV, Allgrove J, Hannan FM, Bossowski A
J Pediatr Endocrinol Metab 2020 Sep 25;33(9):1231-1235. doi: 10.1515/jpem-2020-0015. PMID: 32866121
Nephrocalcinosis, Renal Dysfunction, and Calculi in Patients With Primary Hypoparathyroidism on Long-Term Conventional Therapy.
Saha S, Kandasamy D, Sharma R, Bal C, Sreenivas V, Goswami R
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz319. PMID: 31901096
The Management of Permanent Primary Hypoparathyroidism in Children and Adolescents: A Complex Task.
De Sanctis V, Soliman AT, Di Maio S, Kattamis C
Pediatr Endocrinol Rev 2018 Sep;16(1):194-202. doi: 10.17458/per.vol16.2018.stsm.hypoparathyroidism. PMID: 30371038
Diverse genetic aetiologies and clinical outcomes of paediatric hypoparathyroidism.
Kim JH, Shin YL, Yang S, Cheon CK, Cho JH, Lee BH, Kim GH, Lee JO, Seo EJ, Choi JH, Yoo HW
Clin Endocrinol (Oxf) 2015 Dec;83(6):790-6. Epub 2015 Oct 19 doi: 10.1111/cen.12944. PMID: 26384470
Hypoparathyroidism in pregnancy.
Krysiak R, Kobielusz-Gembala I, Okopien B
Gynecol Endocrinol 2011 Aug;27(8):529-32. Epub 2011 Apr 5 doi: 10.3109/09513590.2010.507284. PMID: 21463229

Clinical prediction guides

Safety and Efficacy of Oral Human Parathyroid Hormone (1-34) in Hypoparathyroidism: An Open-Label Study.
Ish-Shalom S, Caraco Y, Khazen NS, Gershinsky M, Szalat A, Schwartz P, Arbit E, Galitzer H, Tang JC, Burshtein G, Rothner A, Raskin A, Blum M, Fraser WD
J Bone Miner Res 2021 Jun;36(6):1060-1068. Epub 2021 Mar 5 doi: 10.1002/jbmr.4274. PMID: 33666947Free PMC Article
Nephrocalcinosis, Renal Dysfunction, and Calculi in Patients With Primary Hypoparathyroidism on Long-Term Conventional Therapy.
Saha S, Kandasamy D, Sharma R, Bal C, Sreenivas V, Goswami R
J Clin Endocrinol Metab 2020 Apr 1;105(4) doi: 10.1210/clinem/dgz319. PMID: 31901096
Diverse genetic aetiologies and clinical outcomes of paediatric hypoparathyroidism.
Kim JH, Shin YL, Yang S, Cheon CK, Cho JH, Lee BH, Kim GH, Lee JO, Seo EJ, Choi JH, Yoo HW
Clin Endocrinol (Oxf) 2015 Dec;83(6):790-6. Epub 2015 Oct 19 doi: 10.1111/cen.12944. PMID: 26384470
Hypoparathyroidism in pregnancy.
Krysiak R, Kobielusz-Gembala I, Okopien B
Gynecol Endocrinol 2011 Aug;27(8):529-32. Epub 2011 Apr 5 doi: 10.3109/09513590.2010.507284. PMID: 21463229
Histomorphometric features of bone in patients with primary and secondary hypoparathyroidism.
Ubara Y, Fushimi T, Tagami T, Sawa N, Hoshino J, Yokota M, Katori H, Takemoto F, Hara S
Kidney Int 2003 May;63(5):1809-16. doi: 10.1046/j.1523-1755.2003.00916.x. PMID: 12675857

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