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Toxic pneumonitis

MedGen UID:
811389
•Concept ID:
C3714582
•
Disease or Syndrome
Synonyms: acute chemical fume pulmonary edema; acute chemical fume pulmonary oedema; acute chemical pulmonary edema; acute chemical pulmonary oedema; Chemical Pneumonitis; toxic pneumonitis
 
Monarch Initiative: MONDO:0003479

Definition

Inflammation of the lungs caused by the inhalation or aspiration of chemicals. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToxic pneumonitis

Professional guidelines

PubMed

Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment.
Zellner T, Eyer F
Toxicol Lett 2020 Mar 1;320:73-79. Epub 2019 Dec 4 doi: 10.1016/j.toxlet.2019.12.005. PMID: 31811912

Recent clinical studies

Etiology

Timber-colonizing gram-negative bacteria as potential causative agents of respiratory diseases in woodworkers.
Wójcik-Fatla A, Mackiewicz B, Sawczyn-Domańska A, Sroka J, Siwiec J, Paściak M, Szponar B, Pawlik K, Dutkiewicz J
Int Arch Occup Environ Health 2022 Aug;95(6):1179-1193. Epub 2022 Jan 11 doi: 10.1007/s00420-021-01829-1. PMID: 35015109Free PMC Article
Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment.
Zellner T, Eyer F
Toxicol Lett 2020 Mar 1;320:73-79. Epub 2019 Dec 4 doi: 10.1016/j.toxlet.2019.12.005. PMID: 31811912
Endotoxin and cancer.
Lundin JI, Checkoway H
Environ Health Perspect 2009 Sep;117(9):1344-50. Epub 2009 May 7 doi: 10.1289/ehp.0800439. PMID: 19750096Free PMC Article
Endotoxin in the environment--exposure and effects.
Rylander R
J Endotoxin Res 2002;8(4):241-52. doi: 10.1179/096805102125000452. PMID: 12230914
Herbicide (Roundup) pneumonitis.
Pushnoy LA, Avnon LS, Carel RS
Chest 1998 Dec;114(6):1769-71. doi: 10.1378/chest.114.6.1769. PMID: 9872216

Diagnosis

Fire eater's lung: retrospective analysis of 123 cases reported to a National Poison Center.
Franzen D, Kohler M, Degrandi C, Kullak-Ublick GA, Ceschi A
Respiration 2014;87(2):98-104. Epub 2013 Jun 21 doi: 10.1159/000350443. PMID: 23796914
Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review.
McCleskey TM, Buchner V, Field RW, Scott BL
Rev Environ Health 2009 Apr-Jun;24(2):75-115. doi: 10.1515/reveh.2009.24.2.75. PMID: 19658317
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
Mulabecirovic A, Gaulhofer P, Auner HW, Popper H, Krause R, Hesse C, Sill H
Ann Hematol 2004 Jul;83(7):420-2. Epub 2004 May 5 doi: 10.1007/s00277-004-0876-5. PMID: 15133629
Herbicide (Roundup) pneumonitis.
Pushnoy LA, Avnon LS, Carel RS
Chest 1998 Dec;114(6):1769-71. doi: 10.1378/chest.114.6.1769. PMID: 9872216
Many faces of pulmonary aspergillosis.
Sharma OP, Chwogule R
Eur Respir J 1998 Sep;12(3):705-15. doi: 10.1183/09031936.98.12030705. PMID: 9762804

Therapy

Timber-colonizing gram-negative bacteria as potential causative agents of respiratory diseases in woodworkers.
Wójcik-Fatla A, Mackiewicz B, Sawczyn-Domańska A, Sroka J, Siwiec J, Paściak M, Szponar B, Pawlik K, Dutkiewicz J
Int Arch Occup Environ Health 2022 Aug;95(6):1179-1193. Epub 2022 Jan 11 doi: 10.1007/s00420-021-01829-1. PMID: 35015109Free PMC Article
Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment.
Zellner T, Eyer F
Toxicol Lett 2020 Mar 1;320:73-79. Epub 2019 Dec 4 doi: 10.1016/j.toxlet.2019.12.005. PMID: 31811912
Endotoxin and cancer.
Lundin JI, Checkoway H
Environ Health Perspect 2009 Sep;117(9):1344-50. Epub 2009 May 7 doi: 10.1289/ehp.0800439. PMID: 19750096Free PMC Article
Fungal spores: hazardous to health?
Sorenson WG
Environ Health Perspect 1999 Jun;107 Suppl 3(Suppl 3):469-72. doi: 10.1289/ehp.99107s3469. PMID: 10423389Free PMC Article
Herbicide (Roundup) pneumonitis.
Pushnoy LA, Avnon LS, Carel RS
Chest 1998 Dec;114(6):1769-71. doi: 10.1378/chest.114.6.1769. PMID: 9872216

Prognosis

Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment.
Zellner T, Eyer F
Toxicol Lett 2020 Mar 1;320:73-79. Epub 2019 Dec 4 doi: 10.1016/j.toxlet.2019.12.005. PMID: 31811912
Significance of new lung infiltrates in outpatients after lung and heart-lung transplantation.
Díaz-Ravetllat V, Greer M, Haverich A, Warnecke G, Dierich M, Welte T, Gottlieb J
Transpl Infect Dis 2014 Jun;16(3):359-68. Epub 2014 Apr 12 doi: 10.1111/tid.12209. PMID: 24725092Free PMC Article
Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review.
McCleskey TM, Buchner V, Field RW, Scott BL
Rev Environ Health 2009 Apr-Jun;24(2):75-115. doi: 10.1515/reveh.2009.24.2.75. PMID: 19658317
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
Mulabecirovic A, Gaulhofer P, Auner HW, Popper H, Krause R, Hesse C, Sill H
Ann Hematol 2004 Jul;83(7):420-2. Epub 2004 May 5 doi: 10.1007/s00277-004-0876-5. PMID: 15133629
Many faces of pulmonary aspergillosis.
Sharma OP, Chwogule R
Eur Respir J 1998 Sep;12(3):705-15. doi: 10.1183/09031936.98.12030705. PMID: 9762804

Clinical prediction guides

Levels of Clara cell secretory protein and surfactant protein A in municipal solid waste management workers in Ibadan, Southwest Nigeria.
Odewabi AO, Ajibola RS, Oritogun KS, Ekor M
Toxicol Ind Health 2023 May;39(5):267-280. Epub 2023 Apr 21 doi: 10.1177/07482337231169085. PMID: 37082971
Exposures to thoracic particulate matter, endotoxin, and glucan during post-Hurricane Katrina restoration work, New Orleans 2005-2012.
Rando RJ, Kwon CW, Lefante JJ
J Occup Environ Hyg 2014;11(1):9-18. doi: 10.1080/15459624.2013.839879. PMID: 24283332
Recent advances in understanding the biomolecular basis of chronic beryllium disease: a review.
McCleskey TM, Buchner V, Field RW, Scott BL
Rev Environ Health 2009 Apr-Jun;24(2):75-115. doi: 10.1515/reveh.2009.24.2.75. PMID: 19658317
Pulmonary infiltrates in patients with haematologic malignancies: transbronchial lung biopsy increases the diagnostic yield with respect to neoplastic infiltrates and toxic pneumonitis.
Mulabecirovic A, Gaulhofer P, Auner HW, Popper H, Krause R, Hesse C, Sill H
Ann Hematol 2004 Jul;83(7):420-2. Epub 2004 May 5 doi: 10.1007/s00277-004-0876-5. PMID: 15133629

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