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Reactive airway disease

MedGen UID:
811342
•Concept ID:
C3714497
•
Disease or Syndrome
Synonyms: Hyperactive Airway Disease; hyperactive airway disease; Reactive Airway Disease; reactive airway disease; reactive airway disease (AQ)
SNOMED CT: Reactive airway disease (991000119106)
 
Monarch Initiative: MONDO:0100470

Definition

Coughing, wheezing, or shortness of breath that is triggered by allergens, infection, or other irritants. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive airway disease

Professional guidelines

PubMed

Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing.
Kimpen JL
Respir Res 2002;3 Suppl 1(Suppl 1):S40-5. doi: 10.1186/rr183. PMID: 12119057Free PMC Article
Occupational asthma. Diagnosis, management, and prevention.
Newman LS
Clin Chest Med 1995 Dec;16(4):621-36. PMID: 8565404
Management of reactive airway disease.
Jaimovich D, Kecskes SA
Crit Care Clin 1992 Jan;8(1):147-62. PMID: 1732027

Recent clinical studies

Etiology

Bronchopulmonary dysplasia.
Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Obesity-related asthma in adults.
Bhatt NA, Lazarus A
Postgrad Med 2016 Aug;128(6):563-6. Epub 2016 Jul 7 doi: 10.1080/00325481.2016.1204211. PMID: 27336439
Helminths as governors of immune-mediated inflammation.
Elliott DE, Summers RW, Weinstock JV
Int J Parasitol 2007 Apr;37(5):457-64. Epub 2006 Dec 28 doi: 10.1016/j.ijpara.2006.12.009. PMID: 17313951
Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease.
Sigurs N
Respir Res 2002;3 Suppl 1(Suppl 1):S8-14. Epub 2002 Jun 24 doi: 10.1186/rr186. PMID: 12119052Free PMC Article
Enalapril-induced cough.
Gibson GR
Arch Intern Med 1989 Dec;149(12):2701-3. PMID: 2556977

Diagnosis

Bronchopulmonary dysplasia.
Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Methacrylate perspective in current dental practice.
Bishop S, Roberts H
J Esthet Restor Dent 2020 Oct;32(7):673-680. Epub 2020 Aug 3 doi: 10.1111/jerd.12633. PMID: 32744420
Respiratory Considerations Including Airway and Ventilation Issues in Critical Care Obstetric Patients.
Ende H, Varelmann D
Obstet Gynecol Clin North Am 2016 Dec;43(4):699-708. doi: 10.1016/j.ogc.2016.07.002. PMID: 27816155
Regadenoson.
Bengalorkar GM, Bhuvana K, Sarala N, Kumar TN
J Postgrad Med 2012 Apr-Jun;58(2):140-6. doi: 10.4103/0022-3859.97177. PMID: 22718059
Management of reactive airway disease.
Jaimovich D, Kecskes SA
Crit Care Clin 1992 Jan;8(1):147-62. PMID: 1732027

Therapy

Dysphonia associated with the use of inhaled corticosteroids.
Chmielewska M, Akst LM
Curr Opin Otolaryngol Head Neck Surg 2015 Jun;23(3):255-9. doi: 10.1097/MOO.0000000000000153. PMID: 25887975
Regadenoson.
Bengalorkar GM, Bhuvana K, Sarala N, Kumar TN
J Postgrad Med 2012 Apr-Jun;58(2):140-6. doi: 10.4103/0022-3859.97177. PMID: 22718059
Clinical perspectives on the association between respiratory syncytial virus and reactive airway disease.
Sigurs N
Respir Res 2002;3 Suppl 1(Suppl 1):S8-14. Epub 2002 Jun 24 doi: 10.1186/rr186. PMID: 12119052Free PMC Article
Immunodeficiency syndromes and reactive airway disease.
Silk HJ
J Asthma 1994;31(4):231-41. doi: 10.3109/02770909409089471. PMID: 8040149
Enalapril-induced cough.
Gibson GR
Arch Intern Med 1989 Dec;149(12):2701-3. PMID: 2556977

Prognosis

First Time Wheezing in a 2-Year-Old.
Viehl L, Estabrook M, Bhalla S, Lee C, Kemp J, White A
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 22 doi: 10.1542/peds.2020-042085. PMID: 34158315
Mediastinal Lymphadenopathy in Children With Histoplasmosis.
Staszak JK, Zmijewski P, Arnold S, Bagga B, Williams RF
J Surg Res 2019 Dec;244:558-565. Epub 2019 Jul 25 doi: 10.1016/j.jss.2019.06.062. PMID: 31352234
Origins of reactive airways disease in early life: do viral infections play a role?
Piedimonte G
Acta Paediatr Suppl 2002;91(437):6-11. doi: 10.1111/j.1651-2227.2002.tb00152.x. PMID: 12200895
Epidemiologic and clinical evidence of a respiratory syncytial virus-reactive airway disease link.
Sigurs N
Am J Respir Crit Care Med 2001 Mar;163(3 Pt 2):S2-6. doi: 10.1164/ajrccm.163.supplement_1.2011109. PMID: 11254543
Thoracoscopic diaphragmatic plication.
Guy TS, Montany PF
Surg Laparosc Endosc 1998 Aug;8(4):319-21. PMID: 9703610

Clinical prediction guides

Bacillus Calmette-Guérin vaccination as defense against SARS-CoV-2 (BADAS): a randomized controlled trial to protect healthcare workers in the USA by enhanced trained immune responses.
DiNardo AR, Arditi M, Kamat AM, Koster KJ, Carrero S, Nishiguchi T, Lebedev M, Benjamin AB, Avalos P, Lozano M, Moule MG, McCune B, Herron B, Ladki M, Sheikh D, Spears M, Herrejon IA, Dodge C, Kumar S, Hutchison RW, Ofili TU, Opperman LA, Bernard JA, Lerner SP, Udeani G, Neal G, Netea MG, Cirillo JD
Trials 2023 Oct 4;24(1):636. doi: 10.1186/s13063-023-07662-w. PMID: 37794431Free PMC Article
Clinical presentation of paradoxical vocal fold motion or laryngeal dyskinesia in infants.
So RJ, Jenks C, Yi J, Ryan MA, Tunkel DE, Walsh JM
Int J Pediatr Otorhinolaryngol 2022 Nov;162:111304. Epub 2022 Sep 2 doi: 10.1016/j.ijporl.2022.111304. PMID: 36084476
Avoiding unnecessary bronchoscopy in children with suspected foreign body aspiration using computed tomography.
Gibbons AT, Casar Berazaluce AM, Hanke RE, McNinch NL, Person A, Mehlman T, Rubin M, Ponsky TA
J Pediatr Surg 2020 Jan;55(1):176-181. Epub 2019 Oct 25 doi: 10.1016/j.jpedsurg.2019.09.045. PMID: 31706607
Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy.
Johnson DE, Georgieff MK
Am Rev Respir Dis 1989 Dec;140(6):1807-12. doi: 10.1164/ajrccm/140.6.1807. PMID: 2574971
Chronic sinus disease with associated reactive airway disease in children.
Rachelefsky GS, Katz RM, Siegel SC
Pediatrics 1984 Apr;73(4):526-9. PMID: 6709434

Recent systematic reviews

The effects of macrolides in children with reactive airway disease: a systematic review and meta-analysis of randomized controlled trials.
Lei WT, Lin HH, Tsai MC, Hung HH, Cheng YJ, Liu SJ, Lin CY, Yeh TL
Drug Des Devel Ther 2018;12:3825-3845. Epub 2018 Nov 8 doi: 10.2147/DDDT.S183527. PMID: 30510399Free PMC Article
Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome.
Soll R, Ozek E
Cochrane Database Syst Rev 2009 Jan 21;(1):CD000141. doi: 10.1002/14651858.CD000141.pub2. PMID: 19160177
Safety profile of pneumococcal conjugate vaccines: systematic review of pre- and post-licensure data.
Destefano F, Pfeifer D, Nohynek H
Bull World Health Organ 2008 May;86(5):373-80. doi: 10.2471/blt.07.048025. PMID: 18545740Free PMC Article

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