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Oligoastrocytic tumor

MedGen UID:
79185
•Concept ID:
C0280793
•
Neoplastic Process
Synonyms: Mixed Oligodendroglioma Astrocytoma; Mixed Oligodendroglioma-Astrocytoma; Mixed Oligodendroglioma-Astrocytomas; Oligodendroglioma-Astrocytoma, Mixed; Oligodendroglioma-Astrocytomas, Mixed
SNOMED CT: Oligoastrocytoma (22217002)
 
Orphanet: ORPHA251651

Definition

A WHO grade 2 tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO) [from NCI]

Professional guidelines

PubMed

Molecular diagnostics as a tool to personalize treatment in adult glioma patients.
Jeuken JW, van der Maazen RW, Wesseling P
Technol Cancer Res Treat 2006 Jun;5(3):215-29. doi: 10.1177/153303460600500305. PMID: 16700618
Phenotype versus genotype in gliomas displaying inter- or intratumoral histological heterogeneity.
Walker C, du Plessis DG, Joyce KA, Machell Y, Thomson-Hehir J, Al Haddad SA, Broome JC, Warnke PC
Clin Cancer Res 2003 Oct 15;9(13):4841-51. PMID: 14581356

Recent clinical studies

Etiology

The Recurrent-Specific Regulation Network of Prognostic Stemness-Related Signatures in Low-Grade Glioma.
Li J, Zhou M, Huang D, Lin R, Cui X, Chen S, Yao Y, Xian S, Wang S, Fu Q, Zhu J, Yue X, Huang R, Qi E, Huang Z
Dis Markers 2023;2023:2243928. Epub 2023 Jan 17 doi: 10.1155/2023/2243928. PMID: 36703644Free PMC Article
Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005.
Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A, Marcos-Gragera R
J Neurooncol 2011 Jan;101(1):117-23. Epub 2010 Jun 11 doi: 10.1007/s11060-010-0240-7. PMID: 20544374
Oligodendroglial tumors.
Chowdhary S, Chamberlain MC
Expert Rev Neurother 2006 Apr;6(4):519-32. doi: 10.1586/14737175.6.4.519. PMID: 16623651
Initial chemotherapy in gliomatosis cerebri.
Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J, Gervais H, Laigle F, Carpentier A, Mokhtari K, Taillandier L, Chinot O, Duffau H, Honnorat J, Hoang-Xuan K, Delattre JY; ANOCEF group
Neurology 2004 Jul 27;63(2):270-5. doi: 10.1212/01.wnl.0000129985.39973.e4. PMID: 15277619
Prognostic factors for low-grade gliomas.
Stupp R, Janzer RC, Hegi ME, Villemure JG, Mirimanoff RO
Semin Oncol 2003 Dec;30(6 Suppl 19):23-8. doi: 10.1053/j.seminoncol.2003.11.029. PMID: 14765381

Diagnosis

Role of perfusion-weighted imaging at 3T in the histopathological differentiation between astrocytic and oligodendroglial tumors.
Saito T, Yamasaki F, Kajiwara Y, Abe N, Akiyama Y, Kakuda T, Takeshima Y, Sugiyama K, Okada Y, Kurisu K
Eur J Radiol 2012 Aug;81(8):1863-9. Epub 2011 May 4 doi: 10.1016/j.ejrad.2011.04.009. PMID: 21543173
Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005.
Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A, Marcos-Gragera R
J Neurooncol 2011 Jan;101(1):117-23. Epub 2010 Jun 11 doi: 10.1007/s11060-010-0240-7. PMID: 20544374
Oligodendroglial tumors.
Chowdhary S, Chamberlain MC
Expert Rev Neurother 2006 Apr;6(4):519-32. doi: 10.1586/14737175.6.4.519. PMID: 16623651
Initial chemotherapy in gliomatosis cerebri.
Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J, Gervais H, Laigle F, Carpentier A, Mokhtari K, Taillandier L, Chinot O, Duffau H, Honnorat J, Hoang-Xuan K, Delattre JY; ANOCEF group
Neurology 2004 Jul 27;63(2):270-5. doi: 10.1212/01.wnl.0000129985.39973.e4. PMID: 15277619
Prognostic factors for low-grade gliomas.
Stupp R, Janzer RC, Hegi ME, Villemure JG, Mirimanoff RO
Semin Oncol 2003 Dec;30(6 Suppl 19):23-8. doi: 10.1053/j.seminoncol.2003.11.029. PMID: 14765381

Therapy

Cyclin D1 gene G870A variants and primary brain tumors.
Zeybek U, Yaylim I, Ozkan NE, Korkmaz G, Turan S, Kafadar D, Cacina C, Kafadar AM
Asian Pac J Cancer Prev 2013;14(7):4101-6. doi: 10.7314/apjcp.2013.14.7.4101. PMID: 23991960
Glioblastoma multiforme with oligodendroglial component (GBMO): favorable outcome after post-operative radiotherapy and chemotherapy with nimustine (ACNU) and teniposide (VM26).
Vordermark D, Ruprecht K, Rieckmann P, Roggendorf W, Vince GH, Warmuth-Metz M, Kölbl O, Flentje M
BMC Cancer 2006 Oct 18;6:247. doi: 10.1186/1471-2407-6-247. PMID: 17049083Free PMC Article
Oligodendroglial tumors.
Chowdhary S, Chamberlain MC
Expert Rev Neurother 2006 Apr;6(4):519-32. doi: 10.1586/14737175.6.4.519. PMID: 16623651
Initial chemotherapy in gliomatosis cerebri.
Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J, Gervais H, Laigle F, Carpentier A, Mokhtari K, Taillandier L, Chinot O, Duffau H, Honnorat J, Hoang-Xuan K, Delattre JY; ANOCEF group
Neurology 2004 Jul 27;63(2):270-5. doi: 10.1212/01.wnl.0000129985.39973.e4. PMID: 15277619

Prognosis

The Recurrent-Specific Regulation Network of Prognostic Stemness-Related Signatures in Low-Grade Glioma.
Li J, Zhou M, Huang D, Lin R, Cui X, Chen S, Yao Y, Xian S, Wang S, Fu Q, Zhu J, Yue X, Huang R, Qi E, Huang Z
Dis Markers 2023;2023:2243928. Epub 2023 Jan 17 doi: 10.1155/2023/2243928. PMID: 36703644Free PMC Article
Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005.
Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A, Marcos-Gragera R
J Neurooncol 2011 Jan;101(1):117-23. Epub 2010 Jun 11 doi: 10.1007/s11060-010-0240-7. PMID: 20544374
Molecular pathogenesis of oligodendroglial tumors.
Jeuken JW, von Deimling A, Wesseling P
J Neurooncol 2004 Nov;70(2):161-81. doi: 10.1007/s11060-004-2748-1. PMID: 15674476
Initial chemotherapy in gliomatosis cerebri.
Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J, Gervais H, Laigle F, Carpentier A, Mokhtari K, Taillandier L, Chinot O, Duffau H, Honnorat J, Hoang-Xuan K, Delattre JY; ANOCEF group
Neurology 2004 Jul 27;63(2):270-5. doi: 10.1212/01.wnl.0000129985.39973.e4. PMID: 15277619
Prognostic factors for low-grade gliomas.
Stupp R, Janzer RC, Hegi ME, Villemure JG, Mirimanoff RO
Semin Oncol 2003 Dec;30(6 Suppl 19):23-8. doi: 10.1053/j.seminoncol.2003.11.029. PMID: 14765381

Clinical prediction guides

Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma-Tailored Gene Panel.
Zacher A, Kaulich K, Stepanow S, Wolter M, Köhrer K, Felsberg J, Malzkorn B, Reifenberger G
Brain Pathol 2017 Mar;27(2):146-159. Epub 2016 Apr 19 doi: 10.1111/bpa.12367. PMID: 26919320Free PMC Article
Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.
Lass U, Nümann A, von Eckardstein K, Kiwit J, Stockhammer F, Horaczek JA, Veelken J, Herold-Mende C, Jeuken J, von Deimling A, Mueller W
PLoS One 2012;7(7):e41298. Epub 2012 Jul 23 doi: 10.1371/journal.pone.0041298. PMID: 22844452Free PMC Article
Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005.
Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A, Marcos-Gragera R
J Neurooncol 2011 Jan;101(1):117-23. Epub 2010 Jun 11 doi: 10.1007/s11060-010-0240-7. PMID: 20544374
Initial chemotherapy in gliomatosis cerebri.
Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J, Gervais H, Laigle F, Carpentier A, Mokhtari K, Taillandier L, Chinot O, Duffau H, Honnorat J, Hoang-Xuan K, Delattre JY; ANOCEF group
Neurology 2004 Jul 27;63(2):270-5. doi: 10.1212/01.wnl.0000129985.39973.e4. PMID: 15277619
Prognostic factors for low-grade gliomas.
Stupp R, Janzer RC, Hegi ME, Villemure JG, Mirimanoff RO
Semin Oncol 2003 Dec;30(6 Suppl 19):23-8. doi: 10.1053/j.seminoncol.2003.11.029. PMID: 14765381

Recent systematic reviews

Clinical, neuroimaging and histopathological features of gliomatosis cerebri: a systematic review based on synthesis of published individual patient data.
Georgakis MK, Tsivgoulis G, Spinos D, Dimitriou NG, Kyritsis AP, Herrlinger U, Petridou ET
J Neurooncol 2018 Nov;140(2):467-475. Epub 2018 Aug 16 doi: 10.1007/s11060-018-2976-4. PMID: 30117023

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