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Cervical small cell carcinoma

MedGen UID:
79025
•Concept ID:
C0279674
•
Neoplastic Process
Synonyms: Cervical small cell cancer; Cervical Small Cell Carcinoma; cervical small cell carcinoma; Cervical Small Cell Neuroendocrine Carcinoma; Cervix Small Cell Carcinoma; cervix small cell carcinoma; Cervix Uteri Small Cell Carcinoma; cervix uteri small cell carcinoma; SCCE; Small Cell Carcinoma of Cervix; small cell carcinoma of cervix; Small Cell Carcinoma of Cervix Uteri; small cell carcinoma of cervix uteri; Small Cell Carcinoma of the Cervix; small cell carcinoma of the cervix; Small Cell Carcinoma of the Cervix Uteri; small cell carcinoma of the cervix uteri; Small Cell Carcinoma of the Uterine Cervix; small cell carcinoma of the uterine cervix; Small Cell Carcinoma of Uterine Cervix; small cell carcinoma of uterine cervix; Uterine Cervix Small Cell Carcinoma; uterine cervix small cell carcinoma
 
Monarch Initiative: MONDO:0006142

Definition

A small cell neuroendocrine carcinoma arising from the cervix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical small cell carcinoma

Professional guidelines

PubMed

Carcinoma of the cervix following conservative management of cervical intraepithelial neoplasia.
Shumsky AG, Stuart GC, Nation J
Gynecol Oncol 1994 Apr;53(1):50-4. doi: 10.1006/gyno.1994.1086. PMID: 8175022

Recent clinical studies

Etiology

Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Small cell carcinoma as an independent prognostic factor for cervical cancer patients: a population-based analysis.
Miao W, Qiuji W, Congkuan S, Yixin L, Xulong W, Boyu Z, Guizhen Q, Jun Z, Yongchang W
Future Oncol 2021 Aug;17(24):3175-3185. Epub 2021 Jun 22 doi: 10.2217/fon-2020-1081. PMID: 34156306
Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors.
Li P, Ma J, Zhang X, Guo Y, Liu Y, Li X, Zhao D, Wang Z
Diagn Pathol 2018 May 22;13(1):31. doi: 10.1186/s13000-018-0709-9. PMID: 29788963Free PMC Article
Small cell carcinoma of the cervix: analysis of clinical and pathological findings.
Wang PH, Liu YC, Lai CR, Chao HT, Yuan CC, Yu KJ
Eur J Gynaecol Oncol 1998;19(2):189-92. PMID: 9611065

Diagnosis

Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Cervix neuroendocrine carcinoma presenting with severe hypokalemia and Cushing's syndrome.
Di Filippo L, Vitali G, Taccagni G, Pedica F, Guaschino G, Bosi E, Martinenghi S
Endocrine 2020 Feb;67(2):318-320. Epub 2020 Jan 22 doi: 10.1007/s12020-020-02202-x. PMID: 31970585
Brachytherapy and survival in small cell cancer of the cervix and uterus.
Lin AJ, Hassanzadeh C, Markovina S, Schwarz J, Grigsby P
Brachytherapy 2019 Mar-Apr;18(2):163-170. Epub 2018 Dec 15 doi: 10.1016/j.brachy.2018.11.006. PMID: 30563743Free PMC Article
Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors.
Li P, Ma J, Zhang X, Guo Y, Liu Y, Li X, Zhao D, Wang Z
Diagn Pathol 2018 May 22;13(1):31. doi: 10.1186/s13000-018-0709-9. PMID: 29788963Free PMC Article
A case of small cell carcinoma of the uterine cervix presenting Cushing's syndrome.
Hashi A, Yasumizu T, Yoda I, Kou T, Mizuno K, Hirata S, Kato J, Katoh R, Inoue M, Kawaguchi A, Nakazato M, Onaya T
Gynecol Oncol 1996 Jun;61(3):427-31. doi: 10.1006/gyno.1996.0168. PMID: 8641627

Therapy

Brachytherapy and survival in small cell cancer of the cervix and uterus.
Lin AJ, Hassanzadeh C, Markovina S, Schwarz J, Grigsby P
Brachytherapy 2019 Mar-Apr;18(2):163-170. Epub 2018 Dec 15 doi: 10.1016/j.brachy.2018.11.006. PMID: 30563743Free PMC Article
MR appearance of uterine cervical small cell carcinoma.
Yasumoto M, Nakagawa T, Shibuya H, Shida T
Rofo 2003 Dec;175(12):1729-30. doi: 10.1055/s-2003-45327. PMID: 14661148
Small cell carcinoma of the cervix.
Sheridan E, Lorigan PC, Goepel J, Radstone DJ, Coleman RE
Clin Oncol (R Coll Radiol) 1996;8(2):102-5. doi: 10.1016/s0936-6555(96)80115-4. PMID: 8859607

Prognosis

Small Cell (Neuroendocrine) Carcinoma of the Cervix: An Analysis for 19 Cases and Literature Review.
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Small cell carcinoma as an independent prognostic factor for cervical cancer patients: a population-based analysis.
Miao W, Qiuji W, Congkuan S, Yixin L, Xulong W, Boyu Z, Guizhen Q, Jun Z, Yongchang W
Future Oncol 2021 Aug;17(24):3175-3185. Epub 2021 Jun 22 doi: 10.2217/fon-2020-1081. PMID: 34156306
Brachytherapy and survival in small cell cancer of the cervix and uterus.
Lin AJ, Hassanzadeh C, Markovina S, Schwarz J, Grigsby P
Brachytherapy 2019 Mar-Apr;18(2):163-170. Epub 2018 Dec 15 doi: 10.1016/j.brachy.2018.11.006. PMID: 30563743Free PMC Article
Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors.
Li P, Ma J, Zhang X, Guo Y, Liu Y, Li X, Zhao D, Wang Z
Diagn Pathol 2018 May 22;13(1):31. doi: 10.1186/s13000-018-0709-9. PMID: 29788963Free PMC Article
A case of small cell carcinoma of the uterine cervix presenting Cushing's syndrome.
Hashi A, Yasumizu T, Yoda I, Kou T, Mizuno K, Hirata S, Kato J, Katoh R, Inoue M, Kawaguchi A, Nakazato M, Onaya T
Gynecol Oncol 1996 Jun;61(3):427-31. doi: 10.1006/gyno.1996.0168. PMID: 8641627

Clinical prediction guides

Small cell carcinoma as an independent prognostic factor for cervical cancer patients: a population-based analysis.
Miao W, Qiuji W, Congkuan S, Yixin L, Xulong W, Boyu Z, Guizhen Q, Jun Z, Yongchang W
Future Oncol 2021 Aug;17(24):3175-3185. Epub 2021 Jun 22 doi: 10.2217/fon-2020-1081. PMID: 34156306
Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors.
Li P, Ma J, Zhang X, Guo Y, Liu Y, Li X, Zhao D, Wang Z
Diagn Pathol 2018 May 22;13(1):31. doi: 10.1186/s13000-018-0709-9. PMID: 29788963Free PMC Article
A case of uterine cervical adenocarcinoma associated with small cell carcinoma.
Kamiya M, Sato Y, Matsumoto H, Sasaki H, Takahashi S, Yamada S, Ito H, Okagaki A, Iwasa Y, Ban C
J Obstet Gynaecol Res 2008 Dec;34(6):1054-60. doi: 10.1111/j.1447-0756.2008.00828.x. PMID: 19012708
Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix.
Wang HL, Lu DW
Mod Pathol 2004 Jun;17(6):732-8. doi: 10.1038/modpathol.3800112. PMID: 15044919
In situ DNA hybridization of cervical small cell carcinoma and adenocarcinoma using biotin-labeled human Papillomavirus probes.
Wolber RA, Clement PB
Mod Pathol 1991 Jan;4(1):96-100. PMID: 1850520

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