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Chondroblastic osteosarcoma

MedGen UID:
79013
•Concept ID:
C0279603
•
Neoplastic Process
Synonyms: Chondroblastic Osteogenic Sarcoma; chondroblastic osteogenic sarcoma; Chondroblastic Osteosarcoma; chondroblastic osteosarcoma; chondroblastic osteosarcoma (morphologic abnormality); chondrosarcomatous osteogenic sarcoma; CHOS
SNOMED CT: Chondroblastic osteosarcoma (76312009)
 
Monarch Initiative: MONDO:0002627

Definition

An osteosarcoma characterised by the presence of atypical cartilage of variable cellularity. It may or may not be associated with the presence of myxoid areas or focal bone formation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondroblastic osteosarcoma

Professional guidelines

PubMed

Treatment outcome of patients with chondroblastic osteosarcoma of the limbs and pelvis.
Tsagozis P, Laitinen MK, Stevenson JD, Jeys LM, Abudu A, Parry MC
Bone Joint J 2019 Jun;101-B(6):739-744. doi: 10.1302/0301-620X.101B6.BJJ-2018-1090.R1. PMID: 31154835
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA.
VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2016 Jul;124(7):493-500. Epub 2016 Mar 21 doi: 10.1002/cncy.21715. PMID: 26999748
Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases.
Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Takeuchi A, Kimura H, Miwa S, Inatani H, Okamoto H, Yamada S, Ikeda H, Sawada-Kitamura S, Nojima T, Ooi A, Otsuka T
Int J Clin Oncol 2014 Aug;19(4):731-8. Epub 2013 Jul 24 doi: 10.1007/s10147-013-0592-z. PMID: 23881556

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

Recent clinical studies

Etiology

Li-Fraumeni-associated osteosarcomas: The French experience.
Saucier E, Bougeard G, Gomez-Mascard A, Schramm C, Abbas R, Berlanga P, Briandet C, Castex MP, Corradini N, Coze C, Guerrini-Rousseau L, Guinebretière JM, Khneisser P, Lervat C, Mansuy L, Marec-Berard P, Marie-Cardine A, Mascard E, Saumet L, Tabone MD, Winter S, Frebourg T, Gaspar N, Brugieres L
Pediatr Blood Cancer 2024 Dec;71(12):e31362. Epub 2024 Oct 10 doi: 10.1002/pbc.31362. PMID: 39387369
Prognostic factors of chondroblastic osteosarcoma and nomogram development for prediction: A population-based, STROBE-compliant study.
Peng C, Hao Y, Ren Z, Zhu G, Yu L
Medicine (Baltimore) 2021 Jun 11;100(23):e26021. doi: 10.1097/MD.0000000000026021. PMID: 34114989Free PMC Article
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature.
Peddana SK, Ramadas R, Cherian E, Thayalan D
Indian J Dent Res 2017 Jan-Feb;28(1):100-104. doi: 10.4103/ijdr.IJDR_792_14. PMID: 28393823
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA.
VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2016 Jul;124(7):493-500. Epub 2016 Mar 21 doi: 10.1002/cncy.21715. PMID: 26999748
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy.
Benjamin RS, Patel SR
Cancer Treat Res 2009;152:355-63. doi: 10.1007/978-1-4419-0284-9_19. PMID: 20213401

Diagnosis

Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature.
Peddana SK, Ramadas R, Cherian E, Thayalan D
Indian J Dent Res 2017 Jan-Feb;28(1):100-104. doi: 10.4103/ijdr.IJDR_792_14. PMID: 28393823
Chondroblastic osteosarcoma: Cytomorphologic characteristics and differential diagnosis on FNA.
VandenBussche CJ, Sathiyamoorthy S, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2016 Jul;124(7):493-500. Epub 2016 Mar 21 doi: 10.1002/cncy.21715. PMID: 26999748
Chondrosarcomas of the head and neck.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2014 Oct;271(10):2601-9. Epub 2013 Nov 10 doi: 10.1007/s00405-013-2807-3. PMID: 24213203
Diagnosis and treatment of low-grade osteosarcoma: experience with nine cases.
Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Nishida H, Takeuchi A, Kimura H, Miwa S, Inatani H, Okamoto H, Yamada S, Ikeda H, Sawada-Kitamura S, Nojima T, Ooi A, Otsuka T
Int J Clin Oncol 2014 Aug;19(4):731-8. Epub 2013 Jul 24 doi: 10.1007/s10147-013-0592-z. PMID: 23881556

Therapy

Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases.
Paul A, Duncan A, Bacchetta J, Dubourg L, Marec-Bérard P, Tanné C
Nephrol Ther 2021 Dec;17(7):543-546. Epub 2021 Jul 3 doi: 10.1016/j.nephro.2021.05.004. PMID: 34229968
Correlation between apparent diffusion coefficient and histopathology subtypes of osteosarcoma after neoadjuvant chemotherapy.
Wang J, Sun M, Liu D, Hu X, Pui MH, Meng Q, Gao Z
Acta Radiol 2017 Aug;58(8):971-976. Epub 2016 Nov 16 doi: 10.1177/0284185116678276. PMID: 27852643
Maxillary osteosarcoma associated with a dental implant: report of a case and review of the literature regarding implant-related sarcomas.
McGuff HS, Heim-Hall J, Holsinger FC, Jones AA, O'Dell DS, Hafemeister AC
J Am Dent Assoc 2008 Aug;139(8):1052-9. doi: 10.14219/jada.archive.2008.0307. PMID: 18682619
Osteogenic progenitor cell potency after high-dose chemotherapy (COSS-96).
Jäger M, Schultheis A, Westhoff B, Krauspe R
Anticancer Res 2005 Mar-Apr;25(2A):947-54. PMID: 15868932
Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature.
Gadwal SR, Gannon FH, Fanburg-Smith JC, Becoskie EM, Thompson LD
Cancer 2001 Feb 1;91(3):598-605. PMID: 11169944

Prognosis

Prognostic factors of chondroblastic osteosarcoma and nomogram development for prediction: A population-based, STROBE-compliant study.
Peng C, Hao Y, Ren Z, Zhu G, Yu L
Medicine (Baltimore) 2021 Jun 11;100(23):e26021. doi: 10.1097/MD.0000000000026021. PMID: 34114989Free PMC Article
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature.
Peddana SK, Ramadas R, Cherian E, Thayalan D
Indian J Dent Res 2017 Jan-Feb;28(1):100-104. doi: 10.4103/ijdr.IJDR_792_14. PMID: 28393823
Chondrosarcomas of the head and neck.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2014 Oct;271(10):2601-9. Epub 2013 Nov 10 doi: 10.1007/s00405-013-2807-3. PMID: 24213203
Pediatric and adult osteosarcoma: comparisons and contrasts in presentation and therapy.
Benjamin RS, Patel SR
Cancer Treat Res 2009;152:355-63. doi: 10.1007/978-1-4419-0284-9_19. PMID: 20213401
Chondroblastic osteosarcoma of the cuboid: a literature review and report of a rare case.
Fox C, Husain ZS, Shah MB, Lucas DR, Saleh HA
J Foot Ankle Surg 2009 May-Jun;48(3):388-93. doi: 10.1053/j.jfas.2009.02.004. PMID: 19423044

Clinical prediction guides

Prognostic factors of chondroblastic osteosarcoma and nomogram development for prediction: A population-based, STROBE-compliant study.
Peng C, Hao Y, Ren Z, Zhu G, Yu L
Medicine (Baltimore) 2021 Jun 11;100(23):e26021. doi: 10.1097/MD.0000000000026021. PMID: 34114989Free PMC Article
Nomograms for predicting overall survival and cancer-specific survival of chondroblastic osteosarcoma patients.
Gao Z, Zhou S, Song H, Wang Y, He X
J Surg Oncol 2020 Dec;122(8):1676-1684. Epub 2020 Aug 29 doi: 10.1002/jso.26185. PMID: 32862456
Chondroblastic osteosarcoma mimicking periapical abscess.
Yamamoto-Silva FP, Silva BSF, Batista AC, Mendonça EF, Pinto-Júnior DDS, Estrela C
J Appl Oral Sci 2017 Jul-Aug;25(4):455-461. doi: 10.1590/1678-7757-2016-0424. PMID: 28877285Free PMC Article
Primary chondroblastic osteosarcoma of the breast.
El Ochi MR, Zouaidia F, Kabaj R, El Ouazzanni H, Allaoui M, Oukabli M, Al Bouzidi A, El Khannoussi B
Turk Patoloji Derg 2014;30(3):225-7. doi: 10.5146/tjpath.2014.01249. PMID: 26033758
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma.
Gomez-Brouchet A, Mourcin F, Gourraud PA, Bouvier C, De Pinieux G, Le Guelec S, Brousset P, Delisle MB, Schiff C
Hum Pathol 2010 Sep;41(9):1220-30. Epub 2010 Apr 18 doi: 10.1016/j.humpath.2009.10.028. PMID: 20399482

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      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

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