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Pyogenic granuloma of oral mucosa

MedGen UID:
78621
•Concept ID:
C0267019
•
Disease or Syndrome
Synonyms: Oral Mucosa Lobular Capillary Hemangioma; Oral Mucosa Pyogenic Granuloma; Pyogenic Granuloma of Oral Mucosa; Pyogenic Granuloma of the Oral Mucosa
SNOMED CT: Pyogenic granuloma of oral mucosa (76813008)

Definition

A lobular hemangioma arising from the oral mucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyogenic granuloma of oral mucosa

Professional guidelines

PubMed

Recurrence of premalignant oral cavity and oropharynx lesions after pulsed diode laser treatment.
Sagalow ES, Kumar AT, Banoub RG, Xiao KB, Zhan T, Luginbuhl A, Curry JM
Am J Otolaryngol 2022 Sep-Oct;43(5):103556. Epub 2022 Aug 3 doi: 10.1016/j.amjoto.2022.103556. PMID: 35952526
Clinical diagnosis and management of hormonally responsive oral pregnancy tumor (pyogenic granuloma).
Sills ES, Zegarelli DJ, Hoschander MM, Strider WE
J Reprod Med 1996 Jul;41(7):467-70. PMID: 8829057

Recent clinical studies

Etiology

Oral pyogenic granuloma: An 18-year retrospective clinicopathological and immunohistochemical study.
Ribeiro JL, Moraes RM, Carvalho BFC, Nascimento AO, Milhan NVM, Anbinder AL
J Cutan Pathol 2021 Jul;48(7):863-869. Epub 2021 Feb 15 doi: 10.1111/cup.13970. PMID: 33486806
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Malignant melanoma clinically mimicking pyogenic granuloma: comparison of clinical evaluation and histopathology.
Moshe M, Levi A, Ad-El D, Ben-Amitai D, Mimouni D, Didkovsky E, Feinmesser M, Lapidoth M
Melanoma Res 2018 Aug;28(4):363-367. doi: 10.1097/CMR.0000000000000451. PMID: 29750750
Oral and vulvovaginal changes in pregnancy.
Ramos-E-Silva M, Martins NR, Kroumpouzos G
Clin Dermatol 2016 May-Jun;34(3):353-8. Epub 2016 Mar 2 doi: 10.1016/j.clindermatol.2016.02.007. PMID: 27265073
Oral granuloma gravidarum: a retrospective study of 41 cases in Southern Brazil.
Cardoso JA, Spanemberg JC, Cherubini K, Figueiredo MA, Salum FG
J Appl Oral Sci 2013;21(3):215-8. doi: 10.1590/1679-775720130001. PMID: 23857656Free PMC Article

Diagnosis

Oral Pyogenic Granuloma: A Narrative Review.
Lomeli Martinez SM, Carrillo Contreras NG, Gómez Sandoval JR, Zepeda Nuño JS, Gomez Mireles JC, Varela Hernández JJ, Mercado-González AE, Bayardo González RA, Gutiérrez-Maldonado AF
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316885. PMID: 38069207Free PMC Article
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.
Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, Gonçalves S, Lodi G, Hodgson TA
Oral Dis 2019 Jun;25 Suppl 1:193-203. doi: 10.1111/odi.13112. PMID: 31034120
Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities.
McNamara KK, Kalmar JR
Head Neck Pathol 2019 Mar;13(1):4-15. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01002-8. PMID: 30693460Free PMC Article
Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article

Therapy

Recurrence of premalignant oral cavity and oropharynx lesions after pulsed diode laser treatment.
Sagalow ES, Kumar AT, Banoub RG, Xiao KB, Zhan T, Luginbuhl A, Curry JM
Am J Otolaryngol 2022 Sep-Oct;43(5):103556. Epub 2022 Aug 3 doi: 10.1016/j.amjoto.2022.103556. PMID: 35952526
Ramucirumab-related Oral Pyogenic Granuloma: A Report of Two Cases.
Aragaki T, Tomomatsu N, Michi Y, Hosaka H, Fukai Y, Iijima M, Yoda T
Intern Med 2021 Aug 15;60(16):2601-2605. Epub 2021 Mar 8 doi: 10.2169/internalmedicine.6650-20. PMID: 33678742Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Immunolocalisation of tenascin-C in focal reactive overgrowths of oral mucosa.
Mighell AJ, Robinson PA, Hume WJ
J Oral Pathol Med 1996 Apr;25(4):163-9. doi: 10.1111/j.1600-0714.1996.tb00214.x. PMID: 8809684

Prognosis

Vegetating erosive cutaneous lesions and pyogenic granuloma in the course of mucous membrane pemphigoid: a case report and review of literature.
Jakubowska B, Kowalewski C, Ishii N, Hashimoto T, Wozniak K
Int Wound J 2018 Dec;15(6):909-913. Epub 2018 Jun 29 doi: 10.1111/iwj.12943. PMID: 29956465Free PMC Article
Malignant melanoma clinically mimicking pyogenic granuloma: comparison of clinical evaluation and histopathology.
Moshe M, Levi A, Ad-El D, Ben-Amitai D, Mimouni D, Didkovsky E, Feinmesser M, Lapidoth M
Melanoma Res 2018 Aug;28(4):363-367. doi: 10.1097/CMR.0000000000000451. PMID: 29750750
'Granuloma gravidarum': persistence in puerperal period an unusual presentation.
Purwar P, Dixit J, Sheel V, Goel MM
BMJ Case Rep 2015 Jan 9;2015 doi: 10.1136/bcr-2014-206878. PMID: 25576506Free PMC Article
Metastasis of renal clear-cell carcinoma to the oral mucosa, an atypical location.
Maestre-Rodríguez O, González-García R, Mateo-Arias J, Moreno-García C, Serrano-Gil H, Villanueva-Alcojol L, Campos-de-Orellana AM, Monje-Gil F
Med Oral Patol Oral Cir Bucal 2009 Nov 1;14(11):e601-4. doi: 10.4317/medoral.14.e601. PMID: 19680203
Pyogenic granuloma of the stomach successfully treated by endoscopic resection after transarterial embolization of the feeding artery.
Kusakabe A, Kato H, Hayashi K, Igami T, Hasegawa H, Tsuzuki T, Ueda R, Mizokami M
J Gastroenterol 2005 May;40(5):530-5. doi: 10.1007/s00535-004-1579-3. PMID: 15942720

Clinical prediction guides

World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.
Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, Gonçalves S, Lodi G, Hodgson TA
Oral Dis 2019 Jun;25 Suppl 1:193-203. doi: 10.1111/odi.13112. PMID: 31034120
Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta-analysis.
Bett JVS, Batistella EÂ, Melo G, Munhoz EA, Silva CAB, Guerra ENDS, Porporatti AL, De Luca Canto G
J Oral Pathol Med 2019 Apr;48(4):270-277. Epub 2019 Feb 12 doi: 10.1111/jop.12831. PMID: 30673134
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Comparsion of staining characteristics of Toto bodies.
Padala SS, Kiresur MA, Ananthaneni A, Guduru VS, Puneeth HK, Bhavana B
Biotech Histochem 2018;93(5):336-339. Epub 2018 May 21 doi: 10.1080/10520295.2018.1441441. PMID: 29781718
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357

Recent systematic reviews

Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta-analysis.
Aghaeipour F, Salehiniya H, Abbaszadeh H
J Med Virol 2021 Nov;93(11):6089-6099. Epub 2021 Jul 6 doi: 10.1002/jmv.27161. PMID: 34180541
Prevalence of oral mucosal disorders during pregnancy: A systematic review and meta-analysis.
Bett JVS, Batistella EÂ, Melo G, Munhoz EA, Silva CAB, Guerra ENDS, Porporatti AL, De Luca Canto G
J Oral Pathol Med 2019 Apr;48(4):270-277. Epub 2019 Feb 12 doi: 10.1111/jop.12831. PMID: 30673134

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