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Orthostatic syncope

MedGen UID:
776676
•Concept ID:
C0749201
•
Disease or Syndrome; Sign or Symptom
HPO: HP:0012670

Definition

Syncope following a quick change in position from lying down to standing. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrthostatic syncope

Professional guidelines

PubMed

Syncope: Evaluation and Differential Diagnosis.
Bayard M, Gerayli F, Holt J
Am Fam Physician 2023 Nov;108(5):454-463. PMID: 37983697
Salt supplementation in the management of orthostatic intolerance: Vasovagal syncope and postural orthostatic tachycardia syndrome.
Williams EL, Raj SR, Schondorf R, Shen WK, Wieling W, Claydon VE
Auton Neurosci 2022 Jan;237:102906. Epub 2021 Nov 11 doi: 10.1016/j.autneu.2021.102906. PMID: 34823150
Syncope: Approaches to Diagnosis and Management.
Palaniswamy C, Aronow WS, Agrawal N, Balasubramaniyam N, Lakshmanadoss U
Am J Ther 2016 Jan-Feb;23(1):e208-17. doi: 10.1097/MJT.0b013e318256ed0f. PMID: 22960849

Recent clinical studies

Etiology

Syncope: Evaluation and Differential Diagnosis.
Bayard M, Gerayli F, Holt J
Am Fam Physician 2023 Nov;108(5):454-463. PMID: 37983697
Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study.
Ungar A, Mussi C, Ceccofiglio A, Bellelli G, Nicosia F, Bo M, Riccio D, Martone AM, Guadagno L, Noro G, Ghidoni G, Rafanelli M, Marchionni N, Abete P
J Am Geriatr Soc 2016 Aug;64(8):1567-73. Epub 2016 Jun 28 doi: 10.1111/jgs.14225. PMID: 27351866
Evaluation of syncope.
Gauer RL
Am Fam Physician 2011 Sep 15;84(6):640-50. PMID: 21916389
Congenital adrenal hyperplasia: not really a zebra.
Deaton MA, Glorioso JE, McLean DB
Am Fam Physician 1999 Mar 1;59(5):1190-6, 1172. PMID: 10088875
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Diagnosis

Syncope: Evaluation and Differential Diagnosis.
Bayard M, Gerayli F, Holt J
Am Fam Physician 2023 Nov;108(5):454-463. PMID: 37983697
Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article
Do Orthostatic Vital Signs Have Utility in the Evaluation of Syncope?
Schaffer JT, Keim SM, Hunter BR, Kirschner JM, De Lorenzo RA
J Emerg Med 2018 Dec;55(6):780-787. Epub 2018 Oct 10 doi: 10.1016/j.jemermed.2018.09.011. PMID: 30316621
Evaluation of syncope.
Gauer RL
Am Fam Physician 2011 Sep 15;84(6):640-50. PMID: 21916389
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Therapy

Recurrent orthostatic syncope due to left atrial and left ventricular collapse after a continuous-flow left ventricular assist device implantation.
Chandra A, Pradhan R, Kim FY, Frisch DR, Bogar LJ, Bonita R, Cavarocchi NC, Greenspon AJ, Hirose H, Pitcher HT, Rubin S, Mather PJ
J Heart Lung Transplant 2013 Jan;32(1):129-33. doi: 10.1016/j.healun.2012.10.002. PMID: 23260713
Postural tachycardia syndrome: a heterogeneous and multifactorial disorder.
Benarroch EE
Mayo Clin Proc 2012 Dec;87(12):1214-25. Epub 2012 Nov 1 doi: 10.1016/j.mayocp.2012.08.013. PMID: 23122672Free PMC Article
Treatment of autonomic neuropathy, postural tachycardia and orthostatic syncope with octreotide LAR.
Hoeldtke RD, Bryner KD, Hoeldtke ME, Hobbs G
Clin Auton Res 2007 Dec;17(6):334-40. Epub 2007 Aug 31 doi: 10.1007/s10286-007-0436-x. PMID: 17767379
Cerebral syncope in a patient with spinal cord injury.
Bisharat N, Paz E, Klimov A, Friedberg N, Elias M
Pacing Clin Electrophysiol 2002 Mar;25(3):372-3. doi: 10.1046/j.1460-9592.2002.00372.x. PMID: 11990670
Venous plasma adrenaline response to orthostatic syncope during tilting in healthy men.
Tatár P, Bulas J, Kvetnanský R, Strec V
Clin Physiol 1986 Jun;6(3):303-9. doi: 10.1111/j.1475-097x.1986.tb00627.x. PMID: 3087688

Prognosis

Syncope: Evaluation and Differential Diagnosis.
Bayard M, Gerayli F, Holt J
Am Fam Physician 2023 Nov;108(5):454-463. PMID: 37983697
An approach to the clinical assessment and management of syncope in adults.
Ntusi NA, Coccia CB, Cupido BJ, Chin A
S Afr Med J 2015 Aug;105(8):690-3. doi: 10.7196/samjnew.8065. PMID: 26543940
The prevalence and prognostic significance of near syncope and syncope: a prospective study of 395 cases in an emergency department (the SPEED study).
Greve Y, Geier F, Popp S, Bertsch T, Singler K, Meier F, Smolarsky A, Mang H, Müller C, Christ M
Dtsch Arztebl Int 2014 Mar 21;111(12):197-204. doi: 10.3238/arztebl.2014.0197. PMID: 24717304Free PMC Article
Cerebral syncope in a patient with spinal cord injury.
Bisharat N, Paz E, Klimov A, Friedberg N, Elias M
Pacing Clin Electrophysiol 2002 Mar;25(3):372-3. doi: 10.1046/j.1460-9592.2002.00372.x. PMID: 11990670
Mitral valve prolapse.
Devereux RB
J Am Med Womens Assoc (1972) 1994 Nov-Dec;49(6):192-7. PMID: 7829819

Clinical prediction guides

Syncope: Evaluation and Differential Diagnosis.
Bayard M, Gerayli F, Holt J
Am Fam Physician 2023 Nov;108(5):454-463. PMID: 37983697
Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article
How to simplify the implementation of Syncope ESC Guidelines in the Emergency Department and get on the road to achieve "zero inappropriate admissions".
Numeroso F, Casagranda I
Minerva Med 2022 Apr;113(2):228-233. Epub 2021 Jun 28 doi: 10.23736/S0026-4806.21.07580-7. PMID: 34180642
Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study.
Ungar A, Mussi C, Ceccofiglio A, Bellelli G, Nicosia F, Bo M, Riccio D, Martone AM, Guadagno L, Noro G, Ghidoni G, Rafanelli M, Marchionni N, Abete P
J Am Geriatr Soc 2016 Aug;64(8):1567-73. Epub 2016 Jun 28 doi: 10.1111/jgs.14225. PMID: 27351866
The prevalence and prognostic significance of near syncope and syncope: a prospective study of 395 cases in an emergency department (the SPEED study).
Greve Y, Geier F, Popp S, Bertsch T, Singler K, Meier F, Smolarsky A, Mang H, Müller C, Christ M
Dtsch Arztebl Int 2014 Mar 21;111(12):197-204. doi: 10.3238/arztebl.2014.0197. PMID: 24717304Free PMC Article

Recent systematic reviews

Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article

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