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Perinatal Drug Withdrawal

MedGen UID:
771100
•Concept ID:
C3642460
•
Mental or Behavioral Dysfunction

Definition

Withdrawal signs and symptoms that present during the perinatal period and are caused by drug use by the pregnant mother. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerinatal Drug Withdrawal

Professional guidelines

PubMed

Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.
McPhail BT, Emoto C, Butler D, Fukuda T, Akinbi H, Vinks AA
J Clin Pharmacol 2021 Jul;61(7):857-870. Epub 2021 Feb 1 doi: 10.1002/jcph.1811. PMID: 33382111
WFSBP (*) and IAWMH (**) Guidelines for the treatment of alcohol use disorders in pregnant women.
Thibaut F, Chagraoui A, Buckley L, Gressier F, Labad J, Lamy S, Potenza MN, Rondon M, Riecher-Rössler A, Soyka M, Yonkers K
World J Biol Psychiatry 2019 Jan;20(1):17-50. Epub 2019 Jan 11 doi: 10.1080/15622975.2018.1510185. PMID: 30632868
Treatment of Perinatal Opioid Use Disorder.
Boyars L, Guille C
Obstet Gynecol Clin North Am 2018 Sep;45(3):511-524. doi: 10.1016/j.ogc.2018.05.001. PMID: 30092925

Recent clinical studies

Etiology

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.
Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA; ACT NOW Collaborative
N Engl J Med 2023 Jun 22;388(25):2326-2337. Epub 2023 Apr 30 doi: 10.1056/NEJMoa2214470. PMID: 37125831Free PMC Article
Non-pharmacological care for opioid withdrawal in newborns.
Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423Free PMC Article
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Jones HE, Kraft WK
Clin Perinatol 2019 Jun;46(2):349-366. Epub 2019 Mar 30 doi: 10.1016/j.clp.2019.02.013. PMID: 31010564
Safety of Psychotropic Medications During Pregnancy.
Raffi ER, Nonacs R, Cohen LS
Clin Perinatol 2019 Jun;46(2):215-234. Epub 2019 Mar 28 doi: 10.1016/j.clp.2019.02.004. PMID: 31010557
Neonatal opioid withdrawal syndrome.
Sutter MB, Leeman L, Hsi A
Obstet Gynecol Clin North Am 2014 Jun;41(2):317-34. doi: 10.1016/j.ogc.2014.02.010. PMID: 24845493

Diagnosis

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.
Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA; ACT NOW Collaborative
N Engl J Med 2023 Jun 22;388(25):2326-2337. Epub 2023 Apr 30 doi: 10.1056/NEJMoa2214470. PMID: 37125831Free PMC Article
Safety of Psychotropic Medications During Pregnancy.
Raffi ER, Nonacs R, Cohen LS
Clin Perinatol 2019 Jun;46(2):215-234. Epub 2019 Mar 28 doi: 10.1016/j.clp.2019.02.004. PMID: 31010557
A Practical Approach to Neonatal Opiate Withdrawal Syndrome.
Devlin LA, Davis JM
Am J Perinatol 2018 Mar;35(4):324-330. Epub 2017 Nov 3 doi: 10.1055/s-0037-1608630. PMID: 29100261
Behavioral effects of perinatal opioid exposure.
Fodor A, Tímár J, Zelena D
Life Sci 2014 May 28;104(1-2):1-8. Epub 2014 Apr 15 doi: 10.1016/j.lfs.2014.04.006. PMID: 24746901
Perinatal drug abuse.
Glass L, Evans HE
Pediatr Ann 1979 Feb;8(2):84-92. PMID: 460973

Therapy

Zuranolone for the Treatment of Postpartum Depression.
Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, Freeman M, Lasser R, Bullock A, Kotecha M, Li S, Forrestal F, Rana N, Garcia M, Leclair B, Doherty J
Am J Psychiatry 2023 Sep 1;180(9):668-675. Epub 2023 Jul 26 doi: 10.1176/appi.ajp.20220785. PMID: 37491938
Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.
Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA; ACT NOW Collaborative
N Engl J Med 2023 Jun 22;388(25):2326-2337. Epub 2023 Apr 30 doi: 10.1056/NEJMoa2214470. PMID: 37125831Free PMC Article
Non-pharmacological care for opioid withdrawal in newborns.
Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423Free PMC Article
Opioid Use in Pregnancy.
Tobon AL, Habecker E, Forray A
Curr Psychiatry Rep 2019 Nov 16;21(12):118. doi: 10.1007/s11920-019-1110-4. PMID: 31734808Free PMC Article
Safety of Psychotropic Medications During Pregnancy.
Raffi ER, Nonacs R, Cohen LS
Clin Perinatol 2019 Jun;46(2):215-234. Epub 2019 Mar 28 doi: 10.1016/j.clp.2019.02.004. PMID: 31010557

Prognosis

Duration and Timing of In Utero Opioid Exposure and Incidence of Neonatal Withdrawal Syndrome.
Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
Zuranolone for the Treatment of Postpartum Depression.
Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, Freeman M, Lasser R, Bullock A, Kotecha M, Li S, Forrestal F, Rana N, Garcia M, Leclair B, Doherty J
Am J Psychiatry 2023 Sep 1;180(9):668-675. Epub 2023 Jul 26 doi: 10.1176/appi.ajp.20220785. PMID: 37491938
Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.
McPhail BT, Emoto C, Butler D, Fukuda T, Akinbi H, Vinks AA
J Clin Pharmacol 2021 Jul;61(7):857-870. Epub 2021 Feb 1 doi: 10.1002/jcph.1811. PMID: 33382111
Long-term outcome of seizure-free patients and risk factors of relapse following antiepileptic drug withdrawal.
Ou S, Xia L, Li R, Wang L, Xia L, Zhou Q, Pan S
Epilepsy Behav 2018 Nov;88:295-300. Epub 2018 Oct 17 doi: 10.1016/j.yebeh.2018.09.028. PMID: 30340125
Codeine, alone and with paracetamol (acetaminophen), for cancer pain.
Straube C, Derry S, Jackson KC, Wiffen PJ, Bell RF, Strassels S, Straube S
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD006601. doi: 10.1002/14651858.CD006601.pub4. PMID: 25234029Free PMC Article

Clinical prediction guides

Duration and Timing of In Utero Opioid Exposure and Incidence of Neonatal Withdrawal Syndrome.
Wang Y, Berger L, Durrance C, Kirby RS, Kuo D, Pac J, Ehrenthal DB
Obstet Gynecol 2023 Sep 1;142(3):603-611. doi: 10.1097/AOG.0000000000005289. PMID: 37548391Free PMC Article
Zuranolone for the Treatment of Postpartum Depression.
Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, Freeman M, Lasser R, Bullock A, Kotecha M, Li S, Forrestal F, Rana N, Garcia M, Leclair B, Doherty J
Am J Psychiatry 2023 Sep 1;180(9):668-675. Epub 2023 Jul 26 doi: 10.1176/appi.ajp.20220785. PMID: 37491938
Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.
McPhail BT, Emoto C, Butler D, Fukuda T, Akinbi H, Vinks AA
J Clin Pharmacol 2021 Jul;61(7):857-870. Epub 2021 Feb 1 doi: 10.1002/jcph.1811. PMID: 33382111
The offspring of epileptic mother.
Tamer SK, Misra S, Jaiswal S
Indian J Pediatr 1996 Jul-Aug;63(4):523-31. doi: 10.1007/BF02905727. PMID: 10832473
Haloperidol-related dyskinesias and pre- and perinatal complications in autistic children.
Armenteros JL, Adams PB, Campbell M, Eisenberg ZW
Psychopharmacol Bull 1995;31(2):363-9. PMID: 7491393

Recent systematic reviews

Non-pharmacological care for opioid withdrawal in newborns.
Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423Free PMC Article
Guidelines on treatment of perinatal depression with antidepressants: An international review.
Molenaar NM, Kamperman AM, Boyce P, Bergink V
Aust N Z J Psychiatry 2018 Apr;52(4):320-327. Epub 2018 Mar 5 doi: 10.1177/0004867418762057. PMID: 29506399Free PMC Article
Codeine, alone and with paracetamol (acetaminophen), for cancer pain.
Straube C, Derry S, Jackson KC, Wiffen PJ, Bell RF, Strassels S, Straube S
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD006601. doi: 10.1002/14651858.CD006601.pub4. PMID: 25234029Free PMC Article
Opiate treatment for opiate withdrawal in newborn infants.
Osborn DA, Cole MJ, Jeffery HE
Cochrane Database Syst Rev 2002;(3):CD002059. doi: 10.1002/14651858.CD002059. PMID: 12137642

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