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Stage 2A Neuroblastoma

MedGen UID:
769601
•Concept ID:
C3640961
•
Neoplastic Process
Synonym: Stage IIA Neuroblastoma

Definition

Localized tumor with incomplete gross excision; representative ipsilateral nonadherent lymph nodes negative for tumor microscopically. (cancer.gov) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage 2A Neuroblastoma

Professional guidelines

PubMed

Assessment of organ dose reduction and secondary cancer risk associated with the use of proton beam therapy and intensity modulated radiation therapy in treatment of neuroblastomas.
Fuji H, Schneider U, Ishida Y, Konno M, Yamashita H, Kase Y, Murayama S, Onoe T, Ogawa H, Harada H, Asakura H, Nishimura T
Radiat Oncol 2013 Nov 1;8:255. doi: 10.1186/1748-717X-8-255. PMID: 24180282Free PMC Article
Successful treatment of infants with localized neuroblastoma based on their MYCN status.
Iehara T, Hamazaki M, Tajiri T, Kawano Y, Kaneko M, Ikeda H, Hosoi H, Sugimoto T, Sawada T; Japanese Infantile Neuroblastoma Cooperative Study Group
Int J Clin Oncol 2013 Jun;18(3):389-95. Epub 2012 Mar 2 doi: 10.1007/s10147-012-0391-y. PMID: 22383024
Surgical management and outcome of locoregional neuroblastoma: comparison of the Childrens Cancer Group and the international staging systems.
Haase GM, Atkinson JB, Stram DO, Lukens JN, Matthay KK
J Pediatr Surg 1995 Feb;30(2):289-94; discussion 295. doi: 10.1016/0022-3468(95)90576-6. PMID: 7738753

Recent clinical studies

Etiology

Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies.
Yao ZG, Liu XM, Qin YJ
Fetal Pediatr Pathol 2016;35(6):410-415. Epub 2016 Jun 30 doi: 10.1080/15513815.2016.1191568. PMID: 27362946
Successful treatment of infants with localized neuroblastoma based on their MYCN status.
Iehara T, Hamazaki M, Tajiri T, Kawano Y, Kaneko M, Ikeda H, Hosoi H, Sugimoto T, Sawada T; Japanese Infantile Neuroblastoma Cooperative Study Group
Int J Clin Oncol 2013 Jun;18(3):389-95. Epub 2012 Mar 2 doi: 10.1007/s10147-012-0391-y. PMID: 22383024
Extirpation of mass-screened adrenal neuroblastomas by retroperitoneoscopy.
Kouch K, Yoshida H, Matsunaga T, Ohtsuka Y, Okada T, Saito T, Matsuura G, Yamada H, Ohnuma N
Surg Endosc 2003 Nov;17(11):1769-72. Epub 2003 Jun 17 doi: 10.1007/s00464-002-8742-9. PMID: 12802670
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Diagnosis

Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies.
Yao ZG, Liu XM, Qin YJ
Fetal Pediatr Pathol 2016;35(6):410-415. Epub 2016 Jun 30 doi: 10.1080/15513815.2016.1191568. PMID: 27362946
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Martucciello G, Lerone M, Bricco L, Tonini GP, Lombardi L, Del Rossi CG, Bernasconi S
Ital J Pediatr 2012 Mar 19;38:9. doi: 10.1186/1824-7288-38-9. PMID: 22429913Free PMC Article
Extirpation of mass-screened adrenal neuroblastomas by retroperitoneoscopy.
Kouch K, Yoshida H, Matsunaga T, Ohtsuka Y, Okada T, Saito T, Matsuura G, Yamada H, Ohnuma N
Surg Endosc 2003 Nov;17(11):1769-72. Epub 2003 Jun 17 doi: 10.1007/s00464-002-8742-9. PMID: 12802670
Esthesioneuroblastoma: case report.
Gondim J, Ramos F Jr, Azevedo J, Carrero FP Jr, Tella OI Jr
Arq Neuropsiquiatr 2002 Jun;60(2-A):303-7. doi: 10.1590/s0004-282x2002000200024. PMID: 12068366
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320

Therapy

Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
Assessment of organ dose reduction and secondary cancer risk associated with the use of proton beam therapy and intensity modulated radiation therapy in treatment of neuroblastomas.
Fuji H, Schneider U, Ishida Y, Konno M, Yamashita H, Kase Y, Murayama S, Onoe T, Ogawa H, Harada H, Asakura H, Nishimura T
Radiat Oncol 2013 Nov 1;8:255. doi: 10.1186/1748-717X-8-255. PMID: 24180282Free PMC Article
Successful treatment of infants with localized neuroblastoma based on their MYCN status.
Iehara T, Hamazaki M, Tajiri T, Kawano Y, Kaneko M, Ikeda H, Hosoi H, Sugimoto T, Sawada T; Japanese Infantile Neuroblastoma Cooperative Study Group
Int J Clin Oncol 2013 Jun;18(3):389-95. Epub 2012 Mar 2 doi: 10.1007/s10147-012-0391-y. PMID: 22383024
Prognostic value of International Neuroblastoma Pathology Classification in localized resectable peripheral neuroblastic tumors: a histopathologic study of localized neuroblastoma European Study Group 94.01 Trial and Protocol.
Navarro S, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Mosseri V, De Bernardi B, Michon J, Peuchmaur M; European Study Group 94.01 Trial and Protocol
J Clin Oncol 2006 Feb 1;24(4):695-9. doi: 10.1200/JCO.2004.00.8631. PMID: 16446343
Effective T cell regeneration following high-dose chemotherapy rescued with CD34+ cell enriched peripheral blood progenitor cells in children.
Heitger A, Kern H, Mayerl D, Maurer K, Nachbaur D, Frühwirth M, Fink FM, Niederwieser D
Bone Marrow Transplant 1999 Feb;23(4):347-53. doi: 10.1038/sj.bmt.1701588. PMID: 10100578

Prognosis

Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.
Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL
J Clin Oncol 2019 Dec 1;37(34):3243-3255. Epub 2019 Aug 6 doi: 10.1200/JCO.19.00919. PMID: 31386611Free PMC Article
Extirpation of mass-screened adrenal neuroblastomas by retroperitoneoscopy.
Kouch K, Yoshida H, Matsunaga T, Ohtsuka Y, Okada T, Saito T, Matsuura G, Yamada H, Ohnuma N
Surg Endosc 2003 Nov;17(11):1769-72. Epub 2003 Jun 17 doi: 10.1007/s00464-002-8742-9. PMID: 12802670
Esthesioneuroblastoma: case report.
Gondim J, Ramos F Jr, Azevedo J, Carrero FP Jr, Tella OI Jr
Arq Neuropsiquiatr 2002 Jun;60(2-A):303-7. doi: 10.1590/s0004-282x2002000200024. PMID: 12068366
Neonatal neoplasms.
Halperin EC
Int J Radiat Oncol Biol Phys 2000 Apr 1;47(1):171-8. doi: 10.1016/s0360-3016(00)00424-7. PMID: 10758320
Effective T cell regeneration following high-dose chemotherapy rescued with CD34+ cell enriched peripheral blood progenitor cells in children.
Heitger A, Kern H, Mayerl D, Maurer K, Nachbaur D, Frühwirth M, Fink FM, Niederwieser D
Bone Marrow Transplant 1999 Feb;23(4):347-53. doi: 10.1038/sj.bmt.1701588. PMID: 10100578

Clinical prediction guides

A Novel Anticancer Agent, 8-Methoxypyrimido[4',5':4,5]thieno(2,3-b) Quinoline-4(3H)-One Induces Neuro 2a Neuroblastoma Cell Death through p53-Dependent, Caspase-Dependent and -Independent Apoptotic Pathways.
Sahu U, Sidhar H, Ghate PS, Advirao GM, Raghavan SC, Giri RK
PLoS One 2013;8(6):e66430. Epub 2013 Jun 18 doi: 10.1371/journal.pone.0066430. PMID: 23824039Free PMC Article
Ret protein expression in adrenal medullary hyperplasia and pheochromocytoma.
Powers JF, Brachold JM, Tischler AS
Endocr Pathol 2003 Winter;14(4):351-61. doi: 10.1385/ep:14:4:351. PMID: 14739491
Extirpation of mass-screened adrenal neuroblastomas by retroperitoneoscopy.
Kouch K, Yoshida H, Matsunaga T, Ohtsuka Y, Okada T, Saito T, Matsuura G, Yamada H, Ohnuma N
Surg Endosc 2003 Nov;17(11):1769-72. Epub 2003 Jun 17 doi: 10.1007/s00464-002-8742-9. PMID: 12802670
Effective T cell regeneration following high-dose chemotherapy rescued with CD34+ cell enriched peripheral blood progenitor cells in children.
Heitger A, Kern H, Mayerl D, Maurer K, Nachbaur D, Frühwirth M, Fink FM, Niederwieser D
Bone Marrow Transplant 1999 Feb;23(4):347-53. doi: 10.1038/sj.bmt.1701588. PMID: 10100578
Survival from non-stage 4 neuroblastoma without cytotoxic therapy: an analysis of clinical and biological markers.
Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Ambros P, Ambros I, Ladanyi M, Eddy J, Bonilla MA, Gerald W
Eur J Cancer 1997 Oct;33(12):2117-20. doi: 10.1016/s0959-8049(97)00281-5. PMID: 9516865

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