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Neonatal Drug Withdrawal

MedGen UID:
761916
•Concept ID:
C3540839
•
Mental or Behavioral Dysfunction

Definition

A constellation of neurobehavioral features observed following cessation or reduction of antenatal or postnatal drug exposure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Drug Withdrawal

Professional guidelines

PubMed

Neonatal drug withdrawal.
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Update on the pharmacologic management of neonatal abstinence syndrome.
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765
Management of neonatal drug withdrawal.
Goddard J, Wilson GS
J Pediatr 1978 May;92(5):861-2. doi: 10.1016/s0022-3476(78)80197-8. PMID: 641652

Recent clinical studies

Etiology

Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Neonatal drug withdrawal syndrome: cross-country comparison using hospital administrative data in England, the USA, Western Australia and Ontario, Canada.
Davies H, Gilbert R, Johnson K, Petersen I, Nazareth I, O'Donnell M, Guttmann A, Gonzalez-Izquierdo A
Arch Dis Child Fetal Neonatal Ed 2016 Jan;101(1):F26-30. Epub 2015 Aug 19 doi: 10.1136/archdischild-2015-308948. PMID: 26290479
Prescription opioid epidemic and infant outcomes.
Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Neonatal drug withdrawal.
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Update on the pharmacologic management of neonatal abstinence syndrome.
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765

Diagnosis

A Review and Assessment of Drug-Induced Thrombocytosis.
Vo QT, Thompson DF
Ann Pharmacother 2019 May;53(5):523-536. Epub 2018 Dec 10 doi: 10.1177/1060028018819450. PMID: 30525921
Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
Neonatal drug withdrawal.
Barthell JE, Mrozek JD
Minn Med 2013 Mar;96(3):48-50. PMID: 23930471
Neonatal drug withdrawal.
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Update on the pharmacologic management of neonatal abstinence syndrome.
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765

Therapy

A Review and Assessment of Drug-Induced Thrombocytosis.
Vo QT, Thompson DF
Ann Pharmacother 2019 May;53(5):523-536. Epub 2018 Dec 10 doi: 10.1177/1060028018819450. PMID: 30525921
The opioid epidemic and neonatal abstinence syndrome in the USA: a review of the continuum of care.
Pryor JR, Maalouf FI, Krans EE, Schumacher RE, Cooper WO, Patrick SW
Arch Dis Child Fetal Neonatal Ed 2017 Mar;102(2):F183-F187. Epub 2017 Jan 10 doi: 10.1136/archdischild-2015-310045. PMID: 28073819Free PMC Article
Neonatal drug withdrawal.
Hudak ML, Tan RC; COMMITTEE ON DRUGS; COMMITTEE ON FETUS AND NEWBORN; American Academy of Pediatrics
Pediatrics 2012 Feb;129(2):e540-60. Epub 2012 Jan 30 doi: 10.1542/peds.2011-3212. PMID: 22291123
Update on the pharmacologic management of neonatal abstinence syndrome.
Bio LL, Siu A, Poon CY
J Perinatol 2011 Nov;31(11):692-701. Epub 2011 Aug 25 doi: 10.1038/jp.2011.116. PMID: 21869765
Neonatal drug withdrawal.
Pediatrics 1983 Dec;72(6):895-902. PMID: 6139783

Prognosis

Prescription opioid epidemic and infant outcomes.
Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Hyperphagia, weight gain and neonatal drug withdrawal.
Shephard R, Greenough A, Johnson K, Gerada C
Acta Paediatr 2002;91(9):951-3. doi: 10.1080/080352502760272641. PMID: 12412871
Neonatal drug withdrawal. American Academy of Pediatrics Committee on Drugs.
Pediatrics 1998 Jun;101(6):1079-88. PMID: 9614425

Clinical prediction guides

A Quality Improvement Initiative to Increase Scoring Consistency and Accuracy of the Finnegan Tool: Challenges in Obtaining Reliable Assessments of Drug Withdrawal in Neonatal Abstinence Syndrome.
Timpson W, Killoran C, Maranda L, Picarillo A, Bloch-Salisbury E
Adv Neonatal Care 2018 Feb;18(1):70-78. doi: 10.1097/ANC.0000000000000441. PMID: 29045256Free PMC Article
Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.
Huybrechts KF, Bateman BT, Desai RJ, Hernandez-Diaz S, Rough K, Mogun H, Kerzner LS, Davis JM, Stover M, Bartels D, Cottral J, Patorno E
BMJ 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326. PMID: 28768628Free PMC Article
The opioid epidemic and neonatal abstinence syndrome in the USA: a review of the continuum of care.
Pryor JR, Maalouf FI, Krans EE, Schumacher RE, Cooper WO, Patrick SW
Arch Dis Child Fetal Neonatal Ed 2017 Mar;102(2):F183-F187. Epub 2017 Jan 10 doi: 10.1136/archdischild-2015-310045. PMID: 28073819Free PMC Article
Prescription opioid epidemic and infant outcomes.
Patrick SW, Dudley J, Martin PR, Harrell FE, Warren MD, Hartmann KE, Ely EW, Grijalva CG, Cooper WO
Pediatrics 2015 May;135(5):842-50. Epub 2015 Apr 13 doi: 10.1542/peds.2014-3299. PMID: 25869370Free PMC Article
Hyperphagia, weight gain and neonatal drug withdrawal.
Shephard R, Greenough A, Johnson K, Gerada C
Acta Paediatr 2002;91(9):951-3. doi: 10.1080/080352502760272641. PMID: 12412871

Recent systematic reviews

Punitive legal responses to prenatal drug use in the United States: A survey of state policies and systematic review of their public health impacts.
Bruzelius E, Underhill K, Askari MS, Kajeepeta S, Bates L, Prins SJ, Jarlenski M, Martins SS
Int J Drug Policy 2024 Apr;126:104380. Epub 2024 Mar 14 doi: 10.1016/j.drugpo.2024.104380. PMID: 38484529Free PMC Article

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