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Secondary Myelodysplastic Syndrome

MedGen UID:
76156
•Concept ID:
C0280745
•
Neoplastic Process
Synonym: Secondary MDS

Definition

A myelodysplastic syndrome resulting from chemotherapy or radiation therapy for cancer or exposure to certain chemicals. [from NCI]

Professional guidelines

PubMed

Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.
Wojdyla T, Mehta H, Glaubach T, Bertolusso R, Iwanaszko M, Braun R, Corey SJ, Kimmel M
PLoS Comput Biol 2019 Jan;15(1):e1006664. Epub 2019 Jan 7 doi: 10.1371/journal.pcbi.1006664. PMID: 30615612Free PMC Article
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis.
Putzki N, Knipp S, Ramczykowski T, Vago S, Germing U, Diener HC, Limmroth V
Mult Scler 2006 Jun;12(3):363-6. doi: 10.1191/135248506ms1307cr. PMID: 16764353

Recent clinical studies

Etiology

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Secondary myelodysplastic syndrome after small cell lung cancer and esophageal cancer.
Otsuka Y, Konishi T, Nara S, Furushima K, Nakajima K, Shimada H
J Gastroenterol Hepatol 2005 Sep;20(9):1318-21. doi: 10.1111/j.1440-1746.2005.03838.x. PMID: 16105115
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748

Diagnosis

Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myelogenous leukemia after aplastic anemia.
Yoshimi A, Strahm B, Baumann I, Furlan I, Schwarz S, Teigler-Schlegel A, Walther JU, Schlegelberger B, Göhring G, Nöllke P, Führer M, Niemeyer CM
Biol Blood Marrow Transplant 2014 Mar;20(3):425-9. Epub 2013 Dec 5 doi: 10.1016/j.bbmt.2013.11.031. PMID: 24316460
Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma.
Pappo A, Schneider NR, Sanders JM, Buchanan GR
Cancer 1991 Sep 15;68(6):1373-5. doi: 10.1002/1097-0142(19910915)68:6<1373::aid-cncr2820680631>3.0.co;2-s. PMID: 1714791
The myelodysplastic syndromes.
Verwilghen RL, Boogaerts MA
Blood Rev 1987 Mar;1(1):34-43. doi: 10.1016/0268-960x(87)90017-8. PMID: 3332085

Therapy

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Secondary myelodysplastic syndrome after small cell lung cancer and esophageal cancer.
Otsuka Y, Konishi T, Nara S, Furushima K, Nakajima K, Shimada H
J Gastroenterol Hepatol 2005 Sep;20(9):1318-21. doi: 10.1111/j.1440-1746.2005.03838.x. PMID: 16105115
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748
Secondary myelodysplastic syndromes and acute leukemias.
Zeidman A, Dayan DB, Mittelman M
Haematologia (Budap) 1995;27(1):23-8. PMID: 12051292
Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma.
Pappo A, Schneider NR, Sanders JM, Buchanan GR
Cancer 1991 Sep 15;68(6):1373-5. doi: 10.1002/1097-0142(19910915)68:6<1373::aid-cncr2820680631>3.0.co;2-s. PMID: 1714791

Prognosis

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Overview: A New Era of Cancer Genome in Myeloid Malignancies.
Kiyoi H
Oncology 2015;89 Suppl 1:1-3. Epub 2015 Nov 10 doi: 10.1159/000431054. PMID: 26551625
Secondary myelodysplastic syndrome after small cell lung cancer and esophageal cancer.
Otsuka Y, Konishi T, Nara S, Furushima K, Nakajima K, Shimada H
J Gastroenterol Hepatol 2005 Sep;20(9):1318-21. doi: 10.1111/j.1440-1746.2005.03838.x. PMID: 16105115
Secondary myelodysplastic syndromes and acute leukemias.
Zeidman A, Dayan DB, Mittelman M
Haematologia (Budap) 1995;27(1):23-8. PMID: 12051292
The myelodysplastic syndromes.
Verwilghen RL, Boogaerts MA
Blood Rev 1987 Mar;1(1):34-43. doi: 10.1016/0268-960x(87)90017-8. PMID: 3332085

Clinical prediction guides

Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.
Wojdyla T, Mehta H, Glaubach T, Bertolusso R, Iwanaszko M, Braun R, Corey SJ, Kimmel M
PLoS Comput Biol 2019 Jan;15(1):e1006664. Epub 2019 Jan 7 doi: 10.1371/journal.pcbi.1006664. PMID: 30615612Free PMC Article
Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
Shenolikar R, Durden E, Meyer N, Lenhart G, Moore K
Gynecol Oncol 2018 Nov;151(2):190-195. Epub 2018 Sep 27 doi: 10.1016/j.ygyno.2018.09.003. PMID: 30268525
Secondary myelodysplastic syndrome after small cell lung cancer and esophageal cancer.
Otsuka Y, Konishi T, Nara S, Furushima K, Nakajima K, Shimada H
J Gastroenterol Hepatol 2005 Sep;20(9):1318-21. doi: 10.1111/j.1440-1746.2005.03838.x. PMID: 16105115
Evolution of clonal cytogenetic abnormalities in aplastic anemia.
Maciejewski JP, Selleri C
Leuk Lymphoma 2004 Mar;45(3):433-40. doi: 10.1080/10428190310001602363. PMID: 15160903
Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies.
Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C
J Cancer Res Clin Oncol 1998;124(3-4):207-14. doi: 10.1007/s004320050156. PMID: 9619748

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