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Adult Acute Myelomonocytic Leukemia

MedGen UID:
76003
Concept ID:
C0279627
Neoplastic Process
Synonyms: Adult Acute M4 Leukemia; Adult Acute Myelomonocytic Leukemia (M4); Adult AMMoL; M4 Adult Acute Leukemia; M4 Adult Acute Myelomonocytic Leukemia

Definition

An acute myelomonocytic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myelomonocytic Leukemia

Professional guidelines

PubMed

McCullough KB, Kuhn AK, Patnaik MM
Curr Hematol Malig Rep 2021 Jun;16(3):256-266. Epub 2021 Mar 16 doi: 10.1007/s11899-021-00622-8. PMID: 33728588
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Duong HK, Sekeres MA
Clin Interv Aging 2009;4:197-205. Epub 2009 May 14 doi: 10.2147/cia.s3968. PMID: 19503782Free PMC Article

Recent clinical studies

Etiology

Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL
Blood 2021 Mar 11;137(10):1377-1391. doi: 10.1182/blood.2020007897. PMID: 32871587Free PMC Article
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Granfeldt Østgård LS, Medeiros BC, Sengeløv H, Nørgaard M, Andersen MK, Dufva IH, Friis LS, Kjeldsen E, Marcher CW, Preiss B, Severinsen M, Nørgaard JM
J Clin Oncol 2015 Nov 1;33(31):3641-9. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.60.0890. PMID: 26304885
Papaemmanuil E, Gerstung M, Malcovati L, Tauro S, Gundem G, Van Loo P, Yoon CJ, Ellis P, Wedge DC, Pellagatti A, Shlien A, Groves MJ, Forbes SA, Raine K, Hinton J, Mudie LJ, McLaren S, Hardy C, Latimer C, Della Porta MG, O'Meara S, Ambaglio I, Galli A, Butler AP, Walldin G, Teague JW, Quek L, Sternberg A, Gambacorti-Passerini C, Cross NC, Green AR, Boultwood J, Vyas P, Hellstrom-Lindberg E, Bowen D, Cazzola M, Stratton MR, Campbell PJ; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Blood 2013 Nov 21;122(22):3616-27; quiz 3699. Epub 2013 Sep 12 doi: 10.1182/blood-2013-08-518886. PMID: 24030381Free PMC Article
Fernandez HF, Sun Z, Yao X, Litzow MR, Luger SM, Paietta EM, Racevskis J, Dewald GW, Ketterling RP, Bennett JM, Rowe JM, Lazarus HM, Tallman MS
N Engl J Med 2009 Sep 24;361(13):1249-59. doi: 10.1056/NEJMoa0904544. PMID: 19776406Free PMC Article

Diagnosis

Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Martínez-Leboráns L, Victoria-Martínez AM, Torregrosa-Calatayud JL, Alegre de Miquel V
Actas Dermosifiliogr 2016 Nov;107(9):e65-e69. Epub 2016 May 20 doi: 10.1016/j.ad.2016.02.015. PMID: 27210518
Bölke E, Gerber PA, Peiper M, Engers R, Pape H
Wien Klin Wochenschr 2008;120(7-8):209. doi: 10.1007/s00508-008-0952-2. PMID: 18500594
Ramirez-Smiley M, Ingle B
Oncol Nurs Forum 1995 Oct;22(9):1363-8. PMID: 8539177

Therapy

Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Garcia-Manero G, Griffiths EA, Steensma DP, Roboz GJ, Wells R, McCloskey J, Odenike O, DeZern AE, Yee K, Busque L, O'Connell C, Michaelis LC, Brandwein J, Kantarjian H, Oganesian A, Azab M, Savona MR
Blood 2020 Aug 6;136(6):674-683. doi: 10.1182/blood.2019004143. PMID: 32285126Free PMC Article
Fernandez HF, Sun Z, Yao X, Litzow MR, Luger SM, Paietta EM, Racevskis J, Dewald GW, Ketterling RP, Bennett JM, Rowe JM, Lazarus HM, Tallman MS
N Engl J Med 2009 Sep 24;361(13):1249-59. doi: 10.1056/NEJMoa0904544. PMID: 19776406Free PMC Article

Prognosis

Natu AA, Gupta I, Leung N, Alexander MP, Patnaik MM
Kidney Int 2024 Dec;106(6):1062-1071. Epub 2024 Sep 18 doi: 10.1016/j.kint.2024.07.036. PMID: 39299498Free PMC Article
Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Radia DH, Green A, Oni C, Moonim M
Br J Haematol 2020 Mar;188(5):623-640. Epub 2020 Jan 27 doi: 10.1111/bjh.16288. PMID: 31985050
Martínez-Leboráns L, Victoria-Martínez AM, Torregrosa-Calatayud JL, Alegre de Miquel V
Actas Dermosifiliogr 2016 Nov;107(9):e65-e69. Epub 2016 May 20 doi: 10.1016/j.ad.2016.02.015. PMID: 27210518

Clinical prediction guides

Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Itzykson R, Santini V, Thepot S, Ades L, Chaffaut C, Giagounidis A, Morabito M, Droin N, Lübbert M, Sapena R, Nimubona S, Goasguen J, Wattel E, Zini G, Torregrosa Diaz JM, Germing U, Pelizzari AM, Park S, Jaekel N, Metzgeroth G, Onida F, Navarro R, Patriarca A, Stamatoullas A, Götze K, Puttrich M, Mossuto S, Solary E, Gloaguen S, Chevret S, Chermat F, Platzbecker U, Fenaux P
J Clin Oncol 2023 Apr 1;41(10):1888-1897. Epub 2022 Dec 1 doi: 10.1200/JCO.22.00437. PMID: 36455187
Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL
Blood 2021 Mar 11;137(10):1377-1391. doi: 10.1182/blood.2020007897. PMID: 32871587Free PMC Article
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Garcia-Manero G, Griffiths EA, Steensma DP, Roboz GJ, Wells R, McCloskey J, Odenike O, DeZern AE, Yee K, Busque L, O'Connell C, Michaelis LC, Brandwein J, Kantarjian H, Oganesian A, Azab M, Savona MR
Blood 2020 Aug 6;136(6):674-683. doi: 10.1182/blood.2019004143. PMID: 32285126Free PMC Article

Recent systematic reviews

Kunacheewa C, Thongthang P, Ungprasert P, Utchariyaprasit E, Owattanapanich W
Hematology 2019 Dec;24(1):498-506. doi: 10.1080/16078454.2019.1631425. PMID: 31221030
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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