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Nocturnal hypoxemia

MedGen UID:
758908
•Concept ID:
C3531793
•
Finding
Synonyms: Sleep hypoxemia; Sleep related hypoxemia; Sleep-related hypoxemia
SNOMED CT: Sleep related hypoxemia (288581000119102)
 
HPO: HP:0034312

Definition

Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNocturnal hypoxemia

Professional guidelines

PubMed

Sleep breathing disorder frequency, risk factors, and treatment among adults with cystic fibrosis.
Maqsood A, Ma X, Tullis E, Ryan CM, Anand A, Stephenson AL, Vozoris NT
J Cyst Fibros 2024 Jan;23(1):144-149. Epub 2023 Dec 20 doi: 10.1016/j.jcf.2023.12.005. PMID: 38123381
Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management.
Budhiraja R, Siddiqi TA, Quan SF
J Clin Sleep Med 2015 Mar 15;11(3):259-70. doi: 10.5664/jcsm.4540. PMID: 25700872Free PMC Article
The pathophysiology, prevention, and treatment of stroke in sickle cell disease.
Wang WC
Curr Opin Hematol 2007 May;14(3):191-7. doi: 10.1097/MOH.0b013e3280ec5243. PMID: 17414206

Recent clinical studies

Etiology

Hypoxic Burden in Obstructive Sleep Apnea: Present and Future.
Martinez-Garcia MA, Sánchez-de-la-Torre M, White DP, Azarbarzin A
Arch Bronconeumol 2023 Jan;59(1):36-43. Epub 2022 Sep 5 doi: 10.1016/j.arbres.2022.08.005. PMID: 36115739
The Cardiopulmonary Complications of Sickle Cell Disease.
Desai AA, Machado RF, Cohen RT
Hematol Oncol Clin North Am 2022 Dec;36(6):1217-1237. doi: 10.1016/j.hoc.2022.07.014. PMID: 36400540Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease.
Mesarwi OA, Loomba R, Malhotra A
Am J Respir Crit Care Med 2019 Apr 1;199(7):830-841. doi: 10.1164/rccm.201806-1109TR. PMID: 30422676Free PMC Article

Diagnosis

Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Sleep-disordered breathing in cystic fibrosis.
Jagpal SK, Jobanputra AM, Ahmed OH, Santiago TV, Ramagopal M
Pediatr Pulmonol 2021 Feb;56 Suppl 1:S23-S31. doi: 10.1002/ppul.25028. PMID: 33263201
Sleep in Neuromuscular Diseases.
Fermin AM, Afzal U, Culebras A
Sleep Med Clin 2016 Mar;11(1):53-64. Epub 2016 Jan 9 doi: 10.1016/j.jsmc.2015.10.005. PMID: 26972033

Therapy

Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Opioids and obstructive sleep apnea.
Freire C, Sennes LU, Polotsky VY
J Clin Sleep Med 2022 Feb 1;18(2):647-652. doi: 10.5664/jcsm.9730. PMID: 34672945Free PMC Article
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Update on obstructive sleep apnea and its relation to COPD.
Mieczkowski B, Ezzie ME
Int J Chron Obstruct Pulmon Dis 2014;9:349-62. Epub 2014 Apr 8 doi: 10.2147/COPD.S42394. PMID: 24748786Free PMC Article
Almitrine bismesylate.
Smith PD, Gotz VP, Ryerson GG
Drug Intell Clin Pharm 1987 May;21(5):417-21. doi: 10.1177/106002808702100503. PMID: 3556128

Prognosis

Nocturnal hypoxemia and prognosis in patients with acute symptomatic pulmonary embolism.
Barbero E, Rodríguez C, Mañas E, Retegui A, García-Ortega A, García-Sánchez A, Cano-Pumarega I, Martinez-Garcia MÁ, Jimenez D
Int J Cardiol 2023 Oct 15;389:131148. Epub 2023 Jul 7 doi: 10.1016/j.ijcard.2023.131148. PMID: 37423569
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review.
Cowie MR, Linz D, Redline S, Somers VK, Simonds AK
J Am Coll Cardiol 2021 Aug 10;78(6):608-624. doi: 10.1016/j.jacc.2021.05.048. PMID: 34353537
Update on obstructive sleep apnea and its relation to COPD.
Mieczkowski B, Ezzie ME
Int J Chron Obstruct Pulmon Dis 2014;9:349-62. Epub 2014 Apr 8 doi: 10.2147/COPD.S42394. PMID: 24748786Free PMC Article
Do patients with sleep apnea die in their sleep?
Gonzalez-Rothi RJ, Foresman GE, Block AJ
Chest 1988 Sep;94(3):531-8. doi: 10.1378/chest.94.3.531. PMID: 3409732

Clinical prediction guides

Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE
J Alzheimers Dis 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. PMID: 35811518Free PMC Article
Sleep Apnea-Specific Hypoxic Burden, Symptom Subtypes, and Risk of Cardiovascular Events and All-Cause Mortality.
Trzepizur W, Blanchard M, Ganem T, Balusson F, Feuilloy M, Girault JM, Meslier N, Oger E, Paris A, Pigeanne T, Racineux JL, Sabil A, Gervès-Pinquié C, Gagnadoux F
Am J Respir Crit Care Med 2022 Jan 1;205(1):108-117. doi: 10.1164/rccm.202105-1274OC. PMID: 34648724
Cortical afferent inhibition reflects cognitive impairment in obstructive sleep apnea syndrome: a TMS study.
Nardone R, Bergmann J, Brigo F, Höller Y, Schwenker K, Florea C, Kunz AB, Golaszewski S, Trinka E
Sleep Med 2016 Aug;24:51-56. Epub 2016 Aug 26 doi: 10.1016/j.sleep.2016.08.003. PMID: 27810186
Snoring, apneic episodes, and nocturnal hypoxemia among children 6 months to 6 years old. An epidemiologic study of lower limit of prevalence.
Gislason T, Benediktsdóttir B
Chest 1995 Apr;107(4):963-6. doi: 10.1378/chest.107.4.963. PMID: 7705162
Almitrine bismesylate.
Smith PD, Gotz VP, Ryerson GG
Drug Intell Clin Pharm 1987 May;21(5):417-21. doi: 10.1177/106002808702100503. PMID: 3556128

Recent systematic reviews

Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis.
Tan BKJ, Teo YH, Tan NKW, Yap DWT, Sundar R, Lee CH, See A, Toh ST
J Clin Sleep Med 2022 May 1;18(5):1427-1440. doi: 10.5664/jcsm.9772. PMID: 34755597Free PMC Article
Cognitive impairment in obstructive sleep apnea syndrome: a descriptive review.
Caporale M, Palmeri R, Corallo F, Muscarà N, Romeo L, Bramanti A, Marino S, Lo Buono V
Sleep Breath 2021 Mar;25(1):29-40. Epub 2020 May 23 doi: 10.1007/s11325-020-02084-3. PMID: 32447633
Improvement in Nocturnal Hypoxemia in Obese Patients with Obstructive Sleep Apnea after Bariatric Surgery: a Meta-Analysis.
Zhang Y, Wang W, Yang C, Shen J, Shi M, Wang B
Obes Surg 2019 Feb;29(2):601-608. doi: 10.1007/s11695-018-3573-5. PMID: 30411226
The Association of Obstructive Sleep Apnea and Pain Outcomes in Adults: A Systematic Review.
Charokopos A, Card ME, Gunderson C, Steffens C, Bastian LA
Pain Med 2018 Sep 1;19(suppl_1):S69-S75. doi: 10.1093/pm/pny140. PMID: 30203008
Obstructive sleep apnea and oxygen therapy: a systematic review of the literature and meta-analysis.
Mehta V, Vasu TS, Phillips B, Chung F
J Clin Sleep Med 2013 Mar 15;9(3):271-9. doi: 10.5664/jcsm.2500. PMID: 23493498Free PMC Article

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