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Proliferating trichilemmal cyst

MedGen UID:
754766
Concept ID:
C2959585
Neoplastic Process
Synonyms: Pilar Cyst; Pilar cyst; Pilar Tumor; Pilar tumor; Pilar tumour; Proliferating pilar cyst; proliferating pilar cyst; proliferating pilar cystic tumor; proliferating pilar cystic tumour; Proliferating Pilar Tumor; proliferating Pilar tumor; proliferating Pilar tumour; Proliferating Trichilemmal Cyst; proliferating trichilemmal cyst; Proliferating trichilemmal tumor; Proliferating Trichilemmal Tumor; proliferating trichilemmal tumor; proliferating trichilemmal tumour; Proliferating tricholemmal cyst; Proliferating Tricholemmal Tumor; proliferating Tricholemmal tumor; proliferating Tricholemmal tumour
SNOMED CT: Pilar tumor (128638007); Proliferating trichilemmal tumor (446023005); Pilar cyst (419093005); Proliferating trichilemmal cyst (254678009); Proliferating pilar cyst (254678009); Proliferating trichilemmal cyst (446023005); Proliferating tricholemmal cyst (446023005)
 
Monarch Initiative: MONDO:0018850
Orphanet: ORPHA492

Definition

A rare large, multinodular, usually benign, tumor that is generally located in the posterior part of the scalp in aged women (over 50 years). It first appears as a painless nodule that later grows into a solid or partially cystic tumor that is mobile over the underlying subcutaneous tissues. It can present ulceration, inflammation or even bleeding and can cause necrosis of the adjacent tissues. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferating trichilemmal cyst

Professional guidelines

PubMed

Seidenari S, Pellacani G, Nasti S, Tomasi A, Pastorino L, Ghiorzo P, Ruini C, Bianchi-Scarrà G, Pollio A, Mandel VD, Ponti G
Clin Genet 2013 Jul;84(1):65-9. Epub 2012 Nov 8 doi: 10.1111/cge.12040. PMID: 23061468

Recent clinical studies

Etiology

Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Takata M, Quinn AG, Hashimoto K, Rees JL
J Invest Dermatol 1996 May;106(5):1141-4. doi: 10.1111/1523-1747.ep12340190. PMID: 8618054

Diagnosis

Valerio E, Parro FHS, Macedo MP, Pinto CAL
An Bras Dermatol 2019;94(4):452-454. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20198199. PMID: 31644620Free PMC Article
Tellechea O, Cardoso JC, Reis JP, Ramos L, Gameiro AR, Coutinho I, Baptista AP
An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8. doi: 10.1590/abd1806-4841.20154114. PMID: 26734858Free PMC Article
Khaled A, Kourda M, Fazaa B, Kourda J, Ben Jilani S, Kamoun MR, Zermani R
Pathologica 2011 Jun;103(3):73-6. PMID: 22007570
Weiss J, Heine M, Grimmel M, Jung EG
J Am Acad Dermatol 1995 May;32(5 Pt 2):870-3. doi: 10.1016/0190-9622(95)91550-8. PMID: 7722047
Brownstein MH, Arluk DJ
Cancer 1981 Sep 1;48(5):1207-14. doi: 10.1002/1097-0142(19810901)48:5<1207::aid-cncr2820480526>3.0.co;2-1. PMID: 6268280

Prognosis

Leyendecker P, de Cambourg G, Mahé A, Imperiale A, Blondet C
Clin Nucl Med 2015 Jul;40(7):598-9. doi: 10.1097/RLU.0000000000000742. PMID: 25706794
Vandeweyer E, Renard N
Acta Chir Belg 2003 Oct;103(5):507-10. doi: 10.1080/00015458.2003.11679477. PMID: 14653038
Stavrianeas NG, Katoulis AC, Stratigeas NP, Karagianni IN, Patertou-Stavrianea M, Varelzidis AG
Dermatology 1997;195(2):155-8. doi: 10.1159/000245721. PMID: 9310725
Weiss J, Heine M, Grimmel M, Jung EG
J Am Acad Dermatol 1995 May;32(5 Pt 2):870-3. doi: 10.1016/0190-9622(95)91550-8. PMID: 7722047
Brownstein MH, Arluk DJ
Cancer 1981 Sep 1;48(5):1207-14. doi: 10.1002/1097-0142(19810901)48:5<1207::aid-cncr2820480526>3.0.co;2-1. PMID: 6268280

Clinical prediction guides

Juan David DO, María de Los Ángeles VA, Claudia Ileana SC, María Elisa VM
Dermatol Surg 2023 Aug 1;49(8):759-761. Epub 2023 Jul 3 doi: 10.1097/DSS.0000000000003848. PMID: 37399135
Lee DY, Han KM, Yoon JS
Medicine (Baltimore) 2023 Jun 23;102(25):e34035. doi: 10.1097/MD.0000000000034035. PMID: 37352060Free PMC Article
Kang SJ, Wojno TH, Grossniklaus HE
Am J Ophthalmol 2007 Jun;143(6):1065-7. doi: 10.1016/j.ajo.2007.02.027. PMID: 17524785
Poiares Baptista A, Garcia E Silva L, Born MC
J Cutan Pathol 1983 Jun;10(3):178-87. doi: 10.1111/j.1600-0560.1983.tb00324.x. PMID: 6863684
Brownstein MH, Arluk DJ
Cancer 1981 Sep 1;48(5):1207-14. doi: 10.1002/1097-0142(19810901)48:5<1207::aid-cncr2820480526>3.0.co;2-1. PMID: 6268280

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