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Skin Lymphoepithelial Carcinoma

MedGen UID:
699346
•Concept ID:
C1276137
•
Neoplastic Process
Synonyms: Lymphoepithelial tumor of skin; Lymphoepithelioma-like carcinoma of skin; Skin Lymphoepithelioma-Like Carcinoma
SNOMED CT: Lymphoepithelial tumor of skin (403952004); Lymphoepithelioma-like carcinoma of skin (403952004)

Definition

A rare, poorly differentiated squamous cell carcinoma of the skin. It is characterized by the presence of tumor cells islands surrounded and infiltrated by lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Lymphoepithelial Carcinoma

Recent clinical studies

Etiology

Betapapillomavirus in multiple non-melanoma skin cancers of Netherton syndrome: Case report and published work review.
Guerra L, Fortugno P, Sinistro A, Proto V, Zambruno G, Didona B, Castiglia D
J Dermatol 2015 Aug;42(8):786-94. Epub 2015 Apr 28 doi: 10.1111/1346-8138.12913. PMID: 25917539
A spectrum of basaloid morphology in a subset of EBV-associated "lymphoepithelial carcinomas" of major salivary glands.
Friborg J, Hamilton-Therkildsen M, Homoe P, Kristensen C, Hui A, Liu FF, Weinreb I
Head Neck Pathol 2012 Dec;6(4):445-50. Epub 2012 Aug 28 doi: 10.1007/s12105-012-0394-z. PMID: 22926973Free PMC Article
Cutaneous lymphadenoma.
Inalöz HS, Chowdhury MM, Knight AG
J Eur Acad Dermatol Venereol 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x. PMID: 11763398
Cutaneous lymphoepithelial neoplasms.
Okamura JM, Barr RJ
Adv Dermatol 1997;12:277-94; discussion 295. PMID: 8973744
A 20-year series of orbital exenteration.
Levin PS, Dutton JJ
Am J Ophthalmol 1991 Nov 15;112(5):496-501. doi: 10.1016/s0002-9394(14)76848-5. PMID: 1951584

Diagnosis

Lymphoepithelioma-like carcinoma of the skin.
Oliveira CC, Nóbrega VC, Marques MEA
An Bras Dermatol 2018 Mar;93(2):256-258. doi: 10.1590/abd1806-4841.20187205. PMID: 29723365Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Head and neck lesions in the immunocompromised host.
Marsot-Dupuch K, Quillard J, Meyohas MC
Eur Radiol 2004 Mar;14 Suppl 3:E155-67. doi: 10.1007/s00330-003-2045-y. PMID: 14749957
Cutaneous lymphadenoma.
Alsadhan A, Taher M, Shokravi M
J Am Acad Dermatol 2003 Dec;49(6):1115-6. doi: 10.1016/s0190-9622(03)00455-9. PMID: 14639395
Cutaneous lymphadenoma.
Inalöz HS, Chowdhury MM, Knight AG
J Eur Acad Dermatol Venereol 2001 Sep;15(5):481-3. doi: 10.1046/j.1468-3083.2001.00302.x. PMID: 11763398

Therapy

Head and neck lesions in the immunocompromised host.
Marsot-Dupuch K, Quillard J, Meyohas MC
Eur Radiol 2004 Mar;14 Suppl 3:E155-67. doi: 10.1007/s00330-003-2045-y. PMID: 14749957

Prognosis

Second primary cancers in pediatric head and neck cancer survivors in Denmark during 1980-2014: A nationwide study.
Schmidt Jensen J, Grønhøj C, Ruud Kjær EK, Charabi BW, von Buchwald C, Hjuler T
Int J Pediatr Otorhinolaryngol 2019 Dec;127:109648. Epub 2019 Aug 23 doi: 10.1016/j.ijporl.2019.109648. PMID: 31472358
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Lymphoepithelioma-like carcinoma of the skin: a report of 3 Epstein-Barr virus (EBV)-negative additional cases. Immunohistochemical study of the stroma reaction.
Ferlicot S, Plantier F, Rethers L, Bui AD, Wechsler J
J Cutan Pathol 2000 Jul;27(6):306-11. doi: 10.1034/j.1600-0560.2000.027006306.x. PMID: 10885408

Clinical prediction guides

Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Benign lymphoepithelial lesion associated with squamous cell carcinoma of the skin: an immunohistochemical and molecular genetic study.
Miracco C, Schürfeld K, Cardone C, Palummo N, Pirtoli L, Rubegni P
J Cutan Pathol 2002 Jan;29(1):33-7. doi: 10.1034/j.1600-0560.2002.290106.x. PMID: 11841515
Cutaneous lymphadenoma: a case report and review of the literature.
Botella R, Mackie RM
Br J Dermatol 1993 Mar;128(3):339-41. doi: 10.1111/j.1365-2133.1993.tb00181.x. PMID: 8471520

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