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Human T-lymphotropic virus 1 infectious disease

MedGen UID:
6919
•Concept ID:
C0020097
•
Disease or Syndrome
Synonyms: HTLV I Infections; HTLV-I Infection; HTLV-I Infections; Human T lymphotropic Virus 1 Infection; Human T lymphotropic Virus 1 Infections; Human T-lymphotropic Virus 1 Infection; Human T-lymphotropic Virus 1 Infections; Infection, HTLV-I; Infections, HTLV I; Infections, HTLV-I
SNOMED CT: Human T-cell lymphotropic virus (HTLV) 1 infection (429659006); Human T-cell lymphotropic virus 1 infection (429659006); HTLV 1 infection (429659006); HTLV I infection (429659006); Human T-lymphotropic virus 1 infection (429659006)
 
Monarch Initiative: MONDO:0005801

Definition

An infection that is caused by HTLV-1. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman T-lymphotropic virus 1 infectious disease

Professional guidelines

PubMed

Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Molecular epidemiology, genetic variability and evolution of HTLV-1 with special emphasis on African genotypes.
Afonso PV, Cassar O, Gessain A
Retrovirology 2019 Dec 16;16(1):39. doi: 10.1186/s12977-019-0504-z. PMID: 31842895Free PMC Article
HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment.
Futsch N, Mahieux R, Dutartre H
Viruses 2017 Dec 21;10(1) doi: 10.3390/v10010001. PMID: 29267225Free PMC Article

Recent clinical studies

Etiology

HTLV in Sweden.
Vesterbacka J, Svensson AK, Nowak P
AIDS Rev 2024;26(1):41-47. doi: 10.24875/AIDSRev.24000002. PMID: 38530748
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil.
Pereira FM, Almeida MDCC, Santos FLN, Carreiro RP, Galvão-Castro B, Grassi MFR
PLoS One 2020;15(7):e0223087. Epub 2020 Jul 21 doi: 10.1371/journal.pone.0223087. PMID: 32692782Free PMC Article
Sexual transmission of human T-cell lymphotropic virus type 1.
Paiva A, Casseb J
Rev Soc Bras Med Trop 2014 May-Jun;47(3):265-74. doi: 10.1590/0037-8682-0232-2013. PMID: 25075475
Human T-lymphotrophic virus type 1-associated infective dermatitis: a comprehensive review.
Lee R, Schwartz RA
J Am Acad Dermatol 2011 Jan;64(1):152-60. Epub 2010 Aug 5 doi: 10.1016/j.jaad.2009.10.021. PMID: 20691499

Diagnosis

HTLV-1 encephalitis.
King-Robson J, Hampton T, Rosadas C, Taylor GP, Stanton B
Pract Neurol 2022 Feb;22(1):60-63. Epub 2021 Aug 30 doi: 10.1136/practneurol-2021-003053. PMID: 34462338
Stop, think SCORTCH: rethinking the traditional 'TORCH' screen in an era of re-emerging syphilis.
Penner J, Hernstadt H, Burns JE, Randell P, Lyall H
Arch Dis Child 2021 Feb;106(2):117-124. Epub 2020 Jun 25 doi: 10.1136/archdischild-2020-318841. PMID: 32586930
Reducing the global burden of HTLV-1 infection: An agenda for research and action.
Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y
Antiviral Res 2017 Jan;137:41-48. Epub 2016 Nov 11 doi: 10.1016/j.antiviral.2016.10.015. PMID: 27840202
Adult T-cell leukemia/lymphoma and HTLV-1.
Mahieux R, Gessain A
Curr Hematol Malig Rep 2007 Oct;2(4):257-64. doi: 10.1007/s11899-007-0035-x. PMID: 20425378
Human T-lymphotropic virus 1: recent knowledge about an ancient infection.
Verdonck K, González E, Van Dooren S, Vandamme AM, Vanham G, Gotuzzo E
Lancet Infect Dis 2007 Apr;7(4):266-81. doi: 10.1016/S1473-3099(07)70081-6. PMID: 17376384

Therapy

Mogamulizumab for Treatment of Human T-lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Single-Center US-based Series.
Meyerowitz EA, Mukerji SS, Kyle Harrold G, Erdil RM, Chen ST, Rudmann EA, Tsibris A, Venna N, Robbins GK
Clin Infect Dis 2023 Sep 18;77(6):851-856. doi: 10.1093/cid/ciad281. PMID: 37157862Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients.
Varandas CMN, da Silva JLS, Primo JRL, de Oliveira MFSP, Moreno-Carvalho O, Farre L, Bittencourt AL
Clin Infect Dis 2018 Oct 15;67(9):1427-1433. doi: 10.1093/cid/ciy289. PMID: 29912303
Human T-lymphotropic virus/HIV co-infection: a clinical review.
Dhasmana D, Taylor GP
Curr Opin Infect Dis 2014 Feb;27(1):16-28. doi: 10.1097/QCO.0000000000000027. PMID: 24305042
Adult T-cell leukemia/lymphoma and HTLV-1.
Mahieux R, Gessain A
Curr Hematol Malig Rep 2007 Oct;2(4):257-64. doi: 10.1007/s11899-007-0035-x. PMID: 20425378

Prognosis

HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients.
Varandas CMN, da Silva JLS, Primo JRL, de Oliveira MFSP, Moreno-Carvalho O, Farre L, Bittencourt AL
Clin Infect Dis 2018 Oct 15;67(9):1427-1433. doi: 10.1093/cid/ciy289. PMID: 29912303
Human T-lymphotrophic virus type 1-associated infective dermatitis: a comprehensive review.
Lee R, Schwartz RA
J Am Acad Dermatol 2011 Jan;64(1):152-60. Epub 2010 Aug 5 doi: 10.1016/j.jaad.2009.10.021. PMID: 20691499
Human T-lymphotropic virus 1: recent knowledge about an ancient infection.
Verdonck K, González E, Van Dooren S, Vandamme AM, Vanham G, Gotuzzo E
Lancet Infect Dis 2007 Apr;7(4):266-81. doi: 10.1016/S1473-3099(07)70081-6. PMID: 17376384
Adult T-cell leukemia.
Takatsuki K
Intern Med 1995 Oct;34(10):947-52. doi: 10.2169/internalmedicine.34.947. PMID: 8563094

Clinical prediction guides

Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Assone T, Menezes SM, de Toledo Gonçalves F, Folgosi VA, da Silva Prates G, Dierckx T, Braz M, Smid J, Haziot ME, Marcusso RMN, Dahy FE, Vanderlinden E, Claes S, Schols D, Bruhn R, Murphy EL, Penalva de Oliveira AC, Daelemans D, Vercauteren J, Casseb J, Van Weyenbergh J
J Neuroinflammation 2022 Dec 8;19(1):293. doi: 10.1186/s12974-022-02658-w. PMID: 36482436Free PMC Article
HTLV-1-related adult T-cell leukemia/lymphoma: insights in early detection and management.
Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
HTLV, a multi organ oncovirus.
Ramezani S, Rezaee SA, Farjami Z, Ebrahimi N, Abdullabass HK, Ibrahim Jebur MI, Rafatpanah H, Akbarin MM
Microb Pathog 2022 Aug;169:105622. Epub 2022 Jun 7 doi: 10.1016/j.micpath.2022.105622. PMID: 35688412
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern.
Chigbu DI, Jain P, Crumley BL, Patel D, Khan ZK
J Neurovirol 2019 Jun;25(3):289-300. Epub 2019 Jan 28 doi: 10.1007/s13365-019-00720-7. PMID: 30693421
Human T-lymphotropic virus/HIV co-infection: a clinical review.
Dhasmana D, Taylor GP
Curr Opin Infect Dis 2014 Feb;27(1):16-28. doi: 10.1097/QCO.0000000000000027. PMID: 24305042

Recent systematic reviews

Human T Cell Lymphotropic Virus Type 1 Global Prevalence Associated with the Human Development Index: Systematic Review with Meta-Analysis.
Sampaio GCL, Ribeiro JR, de Almeida CN, Boa-Sorte N, Galvão-Castro B, Grassi MFR, Nunes Sá K, Dias CMCC
AIDS Res Hum Retroviruses 2023 Apr;39(4):145-165. Epub 2023 Feb 15 doi: 10.1089/AID.2021.0230. PMID: 36571250
Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa.
Oloumbou EF, Engone-Ondo JD, Mamimandjiami Idam I, Moussavou-Boudzanga P, Mfouo-Tynga I, Mouinga-Ondeme A
Viruses 2022 Dec 16;14(12) doi: 10.3390/v14122808. PMID: 36560812Free PMC Article
Clinical and Laboratory Outcomes in HIV-1 and HTLV-1/2 Coinfection: A Systematic Review.
Montaño-Castellón I, Marconi CSC, Saffe C, Brites C
Front Public Health 2022;10:820727. Epub 2022 Mar 7 doi: 10.3389/fpubh.2022.820727. PMID: 35359787Free PMC Article
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review.
Oliveira PD, Kachimarek AC, Bittencourt AL
J Trop Pediatr 2018 Apr 1;64(2):151-161. doi: 10.1093/tropej/fmx039. PMID: 28582585
Seroprevalence of HTLV-1 and HTLV-2 amongst mothers and children in Malawi within the context of a systematic review and meta-analysis of HTLV seroprevalence in Africa.
Fox JM, Mutalima N, Molyneux E, Carpenter LM, Taylor GP, Bland M, Newton R, Martin F
Trop Med Int Health 2016 Mar;21(3):312-24. Epub 2016 Feb 3 doi: 10.1111/tmi.12659. PMID: 26700941Free PMC Article

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