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Sialoblastoma

MedGen UID:
690115
•Concept ID:
C1266145
•
Neoplastic Process
Synonym: Salivary Gland Sialoblastoma
SNOMED CT: Sialoblastoma (128764008)

Definition

A rare, malignant primitive neoplasm that occurs in the salivary glands. Most tumors arise from the parotid gland, followed by the submandibular gland, and rarely the minor salivary glands. It is usually diagnosed during the neonatal period and presents with painless face swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSialoblastoma

Professional guidelines

PubMed

The congenital basal cell adenoma of salivary glands. Contribution to the differential diagnosis of congenital salivary gland tumours.
Seifert G, Donath K
Virchows Arch 1997 Apr;430(4):311-9. doi: 10.1007/BF01092754. PMID: 9134042

Recent clinical studies

Etiology

The basaloid-spectrum of salivary gland tumors: A focused review with practical diagnostic considerations.
Palsgrove DN
Semin Diagn Pathol 2024 Jul;41(4):173-181. Epub 2024 Jun 13 doi: 10.1053/j.semdp.2024.06.003. PMID: 38879353
Immunohistochemical and molecular profile of salivary gland cancer in children.
Locati LD, Collini P, Imbimbo M, Barisella M, Testi A, Licitra LF, Löning T, Tiemann K, Quattrone P, Bimbatti E, Chiaravalli S, Casanova M, Tamborini E, Carta R, Gasparini P, Guzzo M, Massimino M, Ferrari A
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Jan 31 doi: 10.1002/pbc.26468. PMID: 28139061
Sialoblastoma of the parotid gland in a 13-year-old girl with multiple recurrences and long-term follow-up.
Saravakos P, Hartwein J, Fayyazi A
Head Neck 2016 Jan;38(1):E13-5. Epub 2015 Jul 18 doi: 10.1002/hed.24084. PMID: 25900370
Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery.
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Sialoblastoma and hepatoblastoma in a neonate.
Siddiqi SH, Solomon MP, Haller JO
Pediatr Radiol 2000 May;30(5):349-51. doi: 10.1007/s002470050758. PMID: 10836603

Diagnosis

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Sialoblastoma in chin and management of treatment.
Wang Q, Ma S, Chen H, Yang M, Cai W
Int J Pediatr Otorhinolaryngol 2018 Jun;109:168-173. Epub 2018 Apr 11 doi: 10.1016/j.ijporl.2018.03.023. PMID: 29728174
Pediatric sialoblastoma: Evaluation and management.
Irace AL, Adil EA, Archer NM, Silvera VM, Perez-Atayde A, Rahbar R
Int J Pediatr Otorhinolaryngol 2016 Aug;87:44-9. Epub 2016 Apr 29 doi: 10.1016/j.ijporl.2016.04.037. PMID: 27368441
Sialoblastoma.
Vidyadhar M, Amanda C, Thuan Q, Prabhakaran K
J Pediatr Surg 2008 Oct;43(10):e11-3. doi: 10.1016/j.jpedsurg.2008.04.035. PMID: 18926196
Sialoblastoma: clinicopathological/immunohistochemical study.
Brandwein M, Said-Al-Naief N, Manwani D, Som P, Goldfeder L, Rothschild M, Granowetter L
Am J Surg Pathol 1999 Mar;23(3):342-8. doi: 10.1097/00000478-199903000-00015. PMID: 10078927

Therapy

Sialoblastoma in chin and management of treatment.
Wang Q, Ma S, Chen H, Yang M, Cai W
Int J Pediatr Otorhinolaryngol 2018 Jun;109:168-173. Epub 2018 Apr 11 doi: 10.1016/j.ijporl.2018.03.023. PMID: 29728174
Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery.
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Treatment of metastatic sialoblastoma with chemotherapy and surgery.
Scott JX, Krishnan S, Bourne AJ, Williams MP, Agzarian M, Revesz T
Pediatr Blood Cancer 2008 Jan;50(1):134-7. doi: 10.1002/pbc.20788. PMID: 16514617
Imprint cytology of metastatic sialoblastoma. A case report.
Huang R, Jaffer S
Acta Cytol 2003 Nov-Dec;47(6):1123-6. doi: 10.1159/000326662. PMID: 14674095
Sialoblastoma and epithelial tumors in children: their morphologic spectrum and distribution by age.
Luna MA
Adv Anat Pathol 1999 Sep;6(5):287-92. doi: 10.1097/00125480-199909000-00005. PMID: 10472381

Prognosis

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912
Sialoblastoma in chin and management of treatment.
Wang Q, Ma S, Chen H, Yang M, Cai W
Int J Pediatr Otorhinolaryngol 2018 Jun;109:168-173. Epub 2018 Apr 11 doi: 10.1016/j.ijporl.2018.03.023. PMID: 29728174
Sialoblastoma: utility of Ki-67 and p53 as a prognostic tool and review of literature.
Patil DT, Chou PM
Pediatr Dev Pathol 2010 Jan-Feb;13(1):32-8. doi: 10.2350/09-05-0650-OA.1. PMID: 20001735
Sialoblastoma.
Vidyadhar M, Amanda C, Thuan Q, Prabhakaran K
J Pediatr Surg 2008 Oct;43(10):e11-3. doi: 10.1016/j.jpedsurg.2008.04.035. PMID: 18926196
Sialoblastoma: clinicopathological/immunohistochemical study.
Brandwein M, Said-Al-Naief N, Manwani D, Som P, Goldfeder L, Rothschild M, Granowetter L
Am J Surg Pathol 1999 Mar;23(3):342-8. doi: 10.1097/00000478-199903000-00015. PMID: 10078927

Clinical prediction guides

Immunohistochemical and molecular profile of salivary gland cancer in children.
Locati LD, Collini P, Imbimbo M, Barisella M, Testi A, Licitra LF, Löning T, Tiemann K, Quattrone P, Bimbatti E, Chiaravalli S, Casanova M, Tamborini E, Carta R, Gasparini P, Guzzo M, Massimino M, Ferrari A
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Jan 31 doi: 10.1002/pbc.26468. PMID: 28139061
Congenital minor salivary gland sialoblastoma: a case report and review of the literature.
Saffari Y, Blei F, Warren SM, Milla S, Greco MA
Fetal Pediatr Pathol 2011;30(1):32-9. doi: 10.3109/15513815.2010.502961. PMID: 21204664
Sialoblastoma of salivary glands in children: chemotherapy should be discussed as an alternative to mutilating surgery.
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Sialoblastoma: utility of Ki-67 and p53 as a prognostic tool and review of literature.
Patil DT, Chou PM
Pediatr Dev Pathol 2010 Jan-Feb;13(1):32-8. doi: 10.2350/09-05-0650-OA.1. PMID: 20001735
Sialoblastoma: clinicopathological/immunohistochemical study.
Brandwein M, Said-Al-Naief N, Manwani D, Som P, Goldfeder L, Rothschild M, Granowetter L
Am J Surg Pathol 1999 Mar;23(3):342-8. doi: 10.1097/00000478-199903000-00015. PMID: 10078927

Recent systematic reviews

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review.
Cruz VMS, Pérez-de-Oliveira ME, Dos Santos Leite ÉG, Louredo BVR, Bezerra HKF, Lopes MA, Vargas PA, Santos-Silva AR, Kowalski LP, da Cruz Perez DE
Head Neck 2023 Aug;45(8):2136-2148. Epub 2023 Jun 26 doi: 10.1002/hed.27440. PMID: 37357912

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