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Hiccoughs

MedGen UID:
6835
•Concept ID:
C0019521
•
Finding
Synonyms: Hiccough; Hiccup; Hiccups
SNOMED CT: Singultus (65958008); Hiccough (65958008); Hiccups (65958008); Finding of hiccoughs (65958008); Observation of hiccoughs (65958008); Hiccoughs (65958008)

Definition

An involuntary contraction of the diaphragm against closed vocal cords, producing the ""hic"" sound. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHiccoughs

Professional guidelines

PubMed

Challenges in multiple sclerosis diagnosis: Misunderstanding and misapplication of the McDonald criteria.
Solomon AJ, Pettigrew R, Naismith RT, Chahin S, Krieger S, Weinshenker B
Mult Scler 2021 Feb;27(2):250-258. Epub 2020 Mar 12 doi: 10.1177/1352458520910496. PMID: 32162581
Systemic review: the pathogenesis and pharmacological treatment of hiccups.
Steger M, Schneemann M, Fox M
Aliment Pharmacol Ther 2015 Nov;42(9):1037-50. Epub 2015 Aug 25 doi: 10.1111/apt.13374. PMID: 26307025
Treatment of hiccoughs.
Travis S
Lancet 1991 Aug 24;338(8765):520. doi: 10.1016/0140-6736(91)90598-j. PMID: 1678483

Recent clinical studies

Etiology

Neonatal physiological and behavioral stress during neurological assessment.
Sweeney JK, Blackburn S
J Perinat Neonatal Nurs 2013 Jul-Sep;27(3):242-52; quiz 253-4. doi: 10.1097/JPN.0b013e31829dc329. PMID: 23899803
Electrocardiographic monitoring in healthy young adult outpatients: mandatory or optional?
Zabani I, Vaghadia H, Chilvers CR, Merrick PM
Can J Anaesth 1998 May;45(5 Pt 1):424-8. doi: 10.1007/BF03012577. PMID: 9598256
Induction reflex actions with intravenous nalbuphine as an adjunct to isoflurane.
Mallon JS, Birt C
Can J Anaesth 1989 Jul;36(4):377-81. doi: 10.1007/BF03005333. PMID: 2667779
A controlled investigation of propofol, thiopentone and methohexitone.
Gold MI, Abraham EC, Herrington C
Can J Anaesth 1987 Sep;34(5):478-83. doi: 10.1007/BF03014354. PMID: 3499244
Maternal plasma glucose concentration and fetal breathing movements: a review.
Natale R
Semin Perinatol 1980 Oct;4(4):287-93. PMID: 7001637

Diagnosis

Challenges in multiple sclerosis diagnosis: Misunderstanding and misapplication of the McDonald criteria.
Solomon AJ, Pettigrew R, Naismith RT, Chahin S, Krieger S, Weinshenker B
Mult Scler 2021 Feb;27(2):250-258. Epub 2020 Mar 12 doi: 10.1177/1352458520910496. PMID: 32162581
Neuromyelitis optica spectrum disorders.
Huda S, Whittam D, Bhojak M, Chamberlain J, Noonan C, Jacob A
Clin Med (Lond) 2019 Mar;19(2):169-176. doi: 10.7861/clinmedicine.19-2-169. PMID: 30872305Free PMC Article
Neonatal physiological and behavioral stress during neurological assessment.
Sweeney JK, Blackburn S
J Perinat Neonatal Nurs 2013 Jul-Sep;27(3):242-52; quiz 253-4. doi: 10.1097/JPN.0b013e31829dc329. PMID: 23899803
A case of hiccoughs.
Srirangalingam U, Selvaratnam R, Monson JP, Grossman AB
Clin Med (Lond) 2011 Aug;11(4):366-8. doi: 10.7861/clinmedicine.11-4-366. PMID: 21853836Free PMC Article
Myoclonus in childhood.
Pranzatelli MR
Semin Pediatr Neurol 2003 Mar;10(1):41-51. doi: 10.1016/s1071-9091(02)00008-6. PMID: 12785747

Therapy

The Role of TRP Channels in Nicotinic Provoked Pain and Irritation from the Oral Cavity and Throat: Translating Animal Data to Humans.
Arendt-Nielsen L, Carstens E, Proctor G, Boucher Y, Clavé P, Albin Nielsen K, Nielsen TA, Reeh PW
Nicotine Tob Res 2022 Nov 12;24(12):1849-1860. doi: 10.1093/ntr/ntac054. PMID: 35199839Free PMC Article
Neuromyelitis optica spectrum disorders.
Huda S, Whittam D, Bhojak M, Chamberlain J, Noonan C, Jacob A
Clin Med (Lond) 2019 Mar;19(2):169-176. doi: 10.7861/clinmedicine.19-2-169. PMID: 30872305Free PMC Article
Systemic review: the pathogenesis and pharmacological treatment of hiccups.
Steger M, Schneemann M, Fox M
Aliment Pharmacol Ther 2015 Nov;42(9):1037-50. Epub 2015 Aug 25 doi: 10.1111/apt.13374. PMID: 26307025
Myoclonus in childhood.
Pranzatelli MR
Semin Pediatr Neurol 2003 Mar;10(1):41-51. doi: 10.1016/s1071-9091(02)00008-6. PMID: 12785747
Letter: Carbamazepine for hiccoughs.
McFarling DA, Susac JO
JAMA 1974 Nov 18;230(7):962. doi: 10.1001/jama.230.7.962b. PMID: 4479429

Prognosis

Risk factors for late preterm and term stillbirth: A secondary analysis of an individual participant data meta-analysis.
Thompson RA, Thompson JMD, Wilson J, Cronin RS, Mitchell EA, Raynes-Greenow CH, Li M, Stacey T, Heazell AEP, O'Brien LM, McCowan LME, Anderson NH
BJOG 2023 Aug;130(9):1060-1070. Epub 2023 Mar 21 doi: 10.1111/1471-0528.17444. PMID: 36852504
Neuromyelitis optica spectrum disorders.
Huda S, Whittam D, Bhojak M, Chamberlain J, Noonan C, Jacob A
Clin Med (Lond) 2019 Mar;19(2):169-176. doi: 10.7861/clinmedicine.19-2-169. PMID: 30872305Free PMC Article
Star fruit nephrotoxicity: a case series and literature review.
Wijayaratne DR, Bavanthan V, de Silva MVC, Nazar ALM, Wijewickrama ES
BMC Nephrol 2018 Oct 22;19(1):288. doi: 10.1186/s12882-018-1084-1. PMID: 30348106Free PMC Article
Neonatal physiological and behavioral stress during neurological assessment.
Sweeney JK, Blackburn S
J Perinat Neonatal Nurs 2013 Jul-Sep;27(3):242-52; quiz 253-4. doi: 10.1097/JPN.0b013e31829dc329. PMID: 23899803
Non-ketotic hyperglycinaemia: case report and review of medical literature.
Madu AE, Oliver L
J Matern Fetal Neonatal Med 2013 Mar;26(5):537-9. Epub 2012 Nov 29 doi: 10.3109/14767058.2012.745496. PMID: 23134083

Clinical prediction guides

Diagnostic Utility of High-resolution Esophageal Manometry and Its Correlation with Symptoms.
Musunuri B, Pemmada V, Bhat G, Shetty A, Shetty S, Pai GC
Ann Afr Med 2024 Oct 1;23(4):617-622. Epub 2024 Aug 13 doi: 10.4103/aam.aam_63_24. PMID: 39138977Free PMC Article
Risk factors for late preterm and term stillbirth: A secondary analysis of an individual participant data meta-analysis.
Thompson RA, Thompson JMD, Wilson J, Cronin RS, Mitchell EA, Raynes-Greenow CH, Li M, Stacey T, Heazell AEP, O'Brien LM, McCowan LME, Anderson NH
BJOG 2023 Aug;130(9):1060-1070. Epub 2023 Mar 21 doi: 10.1111/1471-0528.17444. PMID: 36852504
Systemic review: the pathogenesis and pharmacological treatment of hiccups.
Steger M, Schneemann M, Fox M
Aliment Pharmacol Ther 2015 Nov;42(9):1037-50. Epub 2015 Aug 25 doi: 10.1111/apt.13374. PMID: 26307025
Cross-sectional study of quality of life and symptoms in chronic renal disease patients: the Modification of Diet in Renal Disease Study.
Rocco MV, Gassman JJ, Wang SR, Kaplan RM
Am J Kidney Dis 1997 Jun;29(6):888-96. doi: 10.1016/s0272-6386(97)90463-7. PMID: 9186075
Maternal plasma glucose concentration and fetal breathing movements: a review.
Natale R
Semin Perinatol 1980 Oct;4(4):287-93. PMID: 7001637

Recent systematic reviews

Systemic review: the pathogenesis and pharmacological treatment of hiccups.
Steger M, Schneemann M, Fox M
Aliment Pharmacol Ther 2015 Nov;42(9):1037-50. Epub 2015 Aug 25 doi: 10.1111/apt.13374. PMID: 26307025

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